EGRP News Flash - April 18, 2008

FAQs Available About Administrative Supplements for Gene Identification Efforts

Last month, the Epidemiology and Genetics Research Program (EGRP) announced the availability of administrative supplements for NIH-funded genetic association studies aimed at identifying genetic factors involved in complex trait etiology. A set of Frequently Asked Questions and Answers for applicantsExternal Web Site Policy is now available. Requests for supplements are due by May 1, 2008.

All current NIH awardees of R01, P01, and P50 grants, and U01, U19, and U54 cooperative agreements are eligible provided specific conditions are met. This opportunity is part of the NIH-wide Genes, Environment, and Health InitiativeExternal Web Site Policy (GEI), in which all NIH Institutes and Centers participate.

The supplements are to provide support for replication studies (with or without fine-mapping) of genetic regions putatively associated with the studied complex trait(s) (primarily those identified by genome-wide association studies (GWAS)) in order to maximize the productivity of NIH-funded GWAS.

Priority funding will be given to studies with one of more of the following characteristics: synergy with NIH's Gene Environment Association Studies, breadth of available phenotypic and exposure measures for study participants, and plans for sharing data with the research community. Studies should focus on replication in the original discovery population if little replication information is available to date. If the original "hit" has been sufficiently replicated, studies should focus on populations not included in the initial GWAS or subsequent replication studies, such as groups with different environmental exposures.

Budget requests must not exceed $400,000 in total costs for funding not to exceed 12 months. Please note that the NIH Center for Scientific Review (CSR) is not involved in receipt and processing of these requests. NCI's EGRP will receive these administrative supplement requests. See instructionsExternal Web Site Policy.

Contact: Elizabeth Gillanders, Ph.D., Program Director, Host Susceptibility Factors Branch, EGRP

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