EGRP News Flash - January 15, 2009

New Transdisciplinary Cancer Genomics Funding Opportunity Announcement: Post-Genome Wide Association Initiative

The National Cancer Institute's (NCI) Epidemiology and Genetics Research Program (EGRP) is pleased to announce the release of a new Funding Opportunity Announcement (FOA) for transdisciplinary cancer genomics research through the post-Genome Wide Association (post-GWA) Initiative. This FOA will utilize the NIH Cooperative Agreement award mechanism (U19).

The purpose of this FOA is to promote rigorous and efficient investigations on genomic variants tentatively implicated in cancer susceptibility to establish with confidence their significance in cancer. This post-GWA initiative specifically solicits applications proposing collaborative and transdisciplinary research projects addressing two overall goals:

  1. To pursue promising scientific leads from initial Genome Wide Association Studies (GWAS) of cancer (exploiting previously generated "initial scan" GWAS data); and
  2. To accelerate and coordinate integrative post-GWAS discovery research, which could provide the basis for expediting clinical translation and public health dissemination of the findings.

To address these goals, each application should consist of two to three component sub-projects closely pertinent to a single unifying research theme. At least one of these sub-projects must address the replication and/or expansion of prior GWAS findings and at least one sub-project must center on related epidemiologic aspects. In addition, biological and/or mechanistic studies complementing and connecting the required sub-projects are strongly encouraged as a third sub-project. For specific details regarding the required research components, access the NIH Guide for Grants and Contracts: RFA-CA-09-002External Web Site Policy (U19).

The long-term goal is to provide a rigorous knowledge base that would enable clinical translation and public health dissemination of the GWAS findings. It is anticipated that these goals will require collaboration of multi-center teams comprising both epidemiologists and basic scientists. It is also expected that applicants will take advantage of the multiple Project Directors/Principal Investigators (multiple PDs/PIs) option.

In general, applications submitted in response to this FOA should be focused on a single cancer type. Of primary interest are projects to study genetic variations in cancers of the breast, colon, prostate, pancreas, lung, melanoma, and bladder. Studies on other cancer types may also be appropriate. Studies proposing new "discovery" GWAS are NOT eligible for support under this FOA. To maximize scientific benefits and impact of the program, all Post-GWA Initiative applicants must agree to data sharing requirements.

The NCI intends to commit up to $24 million in total costs in FY 2009, and up to $96 million over the planned 4-year project period, to support five to eight awards. The total project period for applications submitted in response to this FOA may not exceed 4 years.

Letters of intent are due April 29, 2009. Applications are due May 29, 2009 and the FOA will expire on May 30, 2009.

EGRP Contacts: Daniela Seminara, Ph.D., M.P.H., Scientific Consortia Coordinator and Program Officer, Office of the Associate Director, Epidemiology and Genetics Research Program and Elizabeth Gillanders, Ph.D., Chief, Host Susceptibility Factors Branch.

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