EGRP News Flash - May 14, 2009

Proposals Sought for Biospecimen Contributing Institutions for Studies in Cancer Tissue Pre-analytic Variables

On behalf of the National Cancer Institute (NCI), the Epidemiology and Genetics Research Program (EGRP) would like to make investigators aware of a new funding opportunity, Contract Solicitation Number: S09-148, Biospecimen Contributing Institutions for Research Studies in Cancer Tissue Pre-Analytical Variables. Responses to this Request for Proposals (RFP) are due by 2:00 p.m. EST June 18, 2009. Selected offerors will contract directly with SAIC-Frederick, Inc., and be subcontractors to it.

Proposals are invited from hospital centers to collect and process, under defined standard operating procedures, well-annotated and differentially preserved cancer and normal tissues. These tissues will be analyzed as part of a larger NCI research project designed to systematically assess the effects of human biospecimen pre-analytical variables on the outcome of genomic and proteomic studies. Data resulting from the research program will provide the basis for evidence-based biospecimen protocols that will increase the quality of human biospecimens for research and the emerging field of personalized medicine.

The initiative will be designed using a transdisciplinary and highly collaborative model, taking into account the many scientific disciplines and operational factors that influence the collection, annotation, processing, and storage of human specimens. Proposals will employ a model of controlled and/or well-annotated biospecimen acquisition and molecular analysis. The research will be accomplished at multiple sites requiring various levels of coordination across several areas of specialization. Findings from this project will be made publicly available.

In actual execution, the work performed under this subcontract will resemble a complex clinical trial with all the appurtenant human subjects protection, study and cohort management, and data collection issues, layered on top of stringent workflow and laboratory protocols required for the collection of biospecimens of high biological quality. Subcontractors will be expected to view the Statement of Work as a clinical trial in which the purpose of the protocol is to collect and process biospecimens under defined experimental conditions.

The operational structure is to include: several hospital centers (Biospecimen Research Network Biospecimen Contributing Institute), a Biospecimen Core Resource, multiple Molecular Analysis Facilities, a Data Coordinating Center, and a Program Management Team.

The initiative is part of NCI's Biospecimen Research Network (BRN), which is a group of intramural and extramural partners that conducts biospecimen acquisition and banking research under the direction of the Office of Biorepositories and Biospecimen Research's (OBBR).

The RFP is available at https://www.fbo.gov/spg/HHS/NIH/FCRF/S09-148/listing.htmlExternal Web Site Policy. Or access it at http://www.fbo.govExternal Web Site Policy and type "RFP S09-148" or "biospecimen" into the quick search field.

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