EGRP News Flash - October 8, 2009

RFA Issued to Compare Design Approaches for Sequencing Disease-associated Regions Found in Genome-wide Association Studies

On October 6, 2009, the National Institutes of Health (NIH) announced a new Funding Opportunity Announcement (FOA), RFA-HG-09-014, inviting research proposals to generate data sets that can be used to learn how to design sequencing follow-up to genome-wide association studies (GWAS). The resulting data sets will allow the participating research groups to find the sets of variants most associated with the diseases or traits studied and to choose the variants that will be studied further (but not supported by this FOA). The participating research groups will also use the data sets to compare various specific design strategies for how well they identify the variants that should be studied further.

This initiative is being supported by NHGRI and the trans-NIH Genes, Environment, and Health Initiative (GEI), which is a four-year program to identify major genetic susceptibility factors for diseases of substantial public health importance and to develop technologies for measuring environmental exposures.

All completed GWAS with replicated disease associations are eligible for this program, whether they have been supported by NIH or by other funding agencies. Complete genotype, phenotype, and exposure data sets must be deposited in dbGaP (or another NIH database with similar broad access). Applicants are strongly encouraged to submit these data by the time of the application.

The funded GWAS groups will work within a consortium with the sequencing centers and analysts to develop the broad design strategy, analyze the sequence data for the individual studies, and evaluate the various design strategies.

This Funding Opportunity will use a cooperative agreement award mechanism. Awards under this program will provide up to $150,000 direct costs (with a maximum of $250,000 total costs) per award to each GWAS group for providing samples, designing the sequencing studies, analyzing the sequence data set for the GWAS, and evaluating the various design strategies. Funds will not be provided for sequencing. The National Human Genome Research Institute (NHGRI) will support the production of the sequence data with the capacity at one of its large-scale sequencing centers, which will also contribute expertise and participate in designing and interpreting studies.

Additionally, funds will not be provided for genotyping, submitting phenotype or exposure data to dbGaP or functional studies. Other NIH Institutes/Centers or funds may support these activities.

It is anticipated that 3-6 awards will be made. The awards will be for one year, starting in late summer 2010.

Letters of Intent are due November 12, and applications are due by December 11, 2009.

Contact: Lisa D. Brooks, Ph.D., Genetic Variation Program, NHGRI; e-mail: lisa.brooks@nih.gov.

  • Access the NIH Guide for Grants and Contracts for details: RFA-HG-09-014External Web Site Policy.

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