EGRP News Flash - February 4, 2011

Genomic Datasets Available for Cancer Research

With approval from the Extramural NCI Data Access Committee (DAC), researchers may now access eight cancer-related genomic datasets currently available via the database of Genotypes and Phenotypes (dbGaP). dbGaP is a data repository developed to archive and distribute the results of studies that have investigated the interaction between genotype and phenotype. The datasets have been generated using a variety of research methodologies, such as genome-wide association studies (GWAS), medical sequencing, molecular diagnostic assays, and studies investigating associations between genotype and non-clinical traits.

Investigators and institutions may submit requests to the Extramural NCI DAC for controlled access to these genomic datasets. Each request will be reviewed and evaluated by the DAC to ensure it conforms to NIH policies and procedures, including consistency between the proposed research use with the data use limitations stipulated by the submitting institution for each dataset.

NIH is interested in advancing genomic studies to identify common genetic factors that influence health and disease. It facilitates broad and consistent access to NIH-supported genomic data to speed the translation of basic genetic research into therapies, products, and procedures that benefit public health. NIH believes that the full value of genomic studies to the public can be realized only if the resulting genotype and phenotype datasets are made available as rapidly as possible to a wide range of scientific investigators. Although such studies generally require significant resources and present challenges in the analysis of large datasets, they provide extraordinary opportunities for making comparisons across multiple studies.

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