Breast and Colon Cancer Family Registries

The Breast Cancer Family Registry (Breast CFR) and the Colon Cancer Family Registry (Colon CFR) were established by the National Cancer Institute (NCI) as a unique resource for investigators to use in conducting studies on the genetics and molecular epidemiology of breast and colon cancer.

Known collectively as the CFRs, they share a central goal: the translation of research to the clinical and prevention settings for the benefit of Registry participants and the general public.

The CFRs are particularly interested in:

  • Identifying and characterizing cancer susceptibility genes;
  • Defining gene-gene and gene-environment interactions in cancer etiology; and
  • Exploring the translational, preventive, and behavioral implications of research findings.

The CFRs do not provide funding for studies; however, researchers can apply to access CFR data and biospecimens contributed by thousands of families from across the spectrum of risk for these cancers and from population-based or relative controls.

Special features of the CFRs include:

  • Population-based and clinic-based ascertainment;
  • Systematic collection of validated family history;
  • Epidemiologic risk factor, clinical, and followup data;
  • Biospecimens (including tumor blocks and Epstein-Barr virus (EBV)-transformed cell lines);
  • Ongoing molecular characterization of the participating families; and
  • A combined informatics center.

For questions about the CFRs, contact:

  • Sheri D, Schully, Ph.D., CFR Program Officer, and Program Director, Host Susceptibility Factors Branch, Epidemiology and Genetics Research Program

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