Breast and Colon Cancer Family Registries

The information on this page is archived and provided for reference purposes only.

The Breast Cancer Family Registry (Breast CFR) and the Colon Cancer Family Registry (Colon CFR) were established by the National Cancer Institute (NCI) as a unique resource for investigators to use in conducting studies on the genetics and molecular epidemiology of breast and colon cancer.

Known collectively as the CFRs, they share a central goal: the translation of research to the clinical and prevention settings for the benefit of Registry participants and the general public.

The CFRs are particularly interested in:

  • Identifying and characterizing cancer susceptibility genes;
  • Defining gene-gene and gene-environment interactions in cancer etiology; and
  • Exploring the translational, preventive, and behavioral implications of research findings.

The CFRs do not provide funding for studies; however, researchers can apply to access CFR data and biospecimens contributed by thousands of families from across the spectrum of risk for these cancers and from population-based or relative controls.

Special features of the CFRs include:

  • Population-based and clinic-based ascertainment;
  • Systematic collection of validated family history;
  • Epidemiologic risk factor, clinical, and followup data;
  • Biospecimens (including tumor blocks and Epstein-Barr virus (EBV)-transformed cell lines);
  • Ongoing molecular characterization of the participating families; and
  • A combined informatics center.

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The information on this page is archived and provided for reference purposes only.