Breast and Colon Cancer Family Registries

For Research Collaborators: Initiating Collaborative Studies

The Cancer Family Registries (CFR) are designed to encourage international collaborative research. An Application and Review Process is available to investigators in the scientific community who wish to undertake collaborative research projects using CFR resources, i.e. data and biospecimen material. Investigators may apply to one or both Registries (Breast CFR and/or Colon CFR). The following documents provide an overview of the process for each registry:

Breast-CFR Review Documents:

• Breast CFR Summary of Review Process - [PDF version 185 kb]
• B-CFR Review Flow Chart for General Applications
• B-CFR Review Flow Chart for Data Only Applications

Colon-CFR Review Documents:

• Colon CFR Summary of Review Process - [PDF version 82 kb]
• C-CFR Review Flow Chart for General Applications
• C-CFR Review Flow Chart for Data Only Applications

More information on the available data and biospecimens available from the CFRs as well as the methods used to recruit participants and collect these materials can be found in the descriptive manuscripts cited below. Questionnaires and data dictionaries used by the CFR centers can be found on the CFR Informatics Support Center website hosted by Research Triangle Institute.

Breast-CFR Descriptive Manuscript:

• John EM, Hopper JL, Beck JC, Knight JA, Neuhausen SL, Senie RT, Ziogas A, Andrulis IL, Anton-Culver H, Boyd N, Buys SS, Daly MB, O’Malley FP, Santella RM, Southey MC, Venne VL, Venter DJ, West DW, Whittemore AS, Seminara D. The Breast Cancer Family Registry (Breast CFR): an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res 2004;6(4):R375-89.

Colon-CFR Descriptive Manuscript:

• Newcomb PA, Baron J, Cotterchio M, Gallinger S, Grove J, Haile R, Hall D, Hopper JL, Jass J, Le Marchand L, Lindor N, Potter JD, Templeton AS, Seminara D, Thibodeau S for the Colon Cancer Family Registry. Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer. Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2331-2343.

To propose a study, investigators should submit a New Application online. The staff at NCI, along with CFR investigators, will then guide the investigator through the review process. For review deadlines of proposals involving biospecimen material and/or participant contact, please see tables below. Data-only proposals are reviewed on a rolling basis.

Application for Use of Resources
Breast Cancer Family Registry Submission and Review Cycles, 2008
(for biospecimens and/or participant contact)

	Cycle I	Cycle II	Cycle III
Proposal Development (2 months)	September-October	January-February	May-June
Draft Submission Deadline	November 1	March 1	July 1
Final Submission Deadline	December 1	April 1	August 1
Advisory Committee Review	January 30	May 14	September 17

Application for Use of Resources
Colon Cancer Family Registry Submission and Review Cycles, 2008
(for biospecimens and/or participant contact)

	Cycle I	Cycle II	Cycle III
Proposal Development (2 months)	September-October	January-February	May-June
Draft Submission Deadline	November 1	March 1	July 1
Final Submission Deadline	December 1	April 1	August 1
Advisory Committee Review	January 23	May 27	September 16

For further information concerning CFR collaborations, including inquiries about the review process or available resources, please contact Daniela Seminara, Ph.D., M.P.H., (301-594-7347) or Michael Burgio, Ph.D., (301-594-3424).