Breast Cancer Family Registry (BCFR) Cohort
Principal Investigators (PIs):
- Irene A. Andrulis, Ph.D.
The Lunenfeld-Tanenbaum Research Institute
- Saundra S. Buys, M.D.
Huntsman Cancer Institute at the University of Utah
- Mary Daly, M.D., Ph.D.
Fox Chase Cancer Center
- John L. Hopper, Ph.D.
University of Melbourne
- Esther M. John, Ph.D.
Cancer Prevention Institute of California
- Mary Beth Terry, Ph.D.
Funded Since: 1995
Funding Source: National Cancer Institute
Year(s) of Enrollment: 1996-2012
Study Website: http://www.bcfamilyregistry.org
The Breast Cancer Family Registry (BCFR) Cohort is an international resource of multi-generational families, data, and biospecimens established in 1995 for interdisciplinary collaborative research on the genetic epidemiology of breast cancer. Questionnaire data, clinical data and (when available) biospecimens have been collected for over 30,000 women and men from nearly 12,000 families. The families were recruited through population-based cancer registries, clinical settings, and community outreach from four areas of the U.S.: 1) the Greater San Francisco Bay area, California; 2) New York City, New York; 3) Philadelphia, Pennsylvania; 4) Salt Lake City, Utah; as well as 5) the Province of Ontario, Canada, and 6) the metropolitan areas of Melbourne and Sydney, Australia. The families are being followed to update family history and epidemiological data through questionnaires and expand the overall cohort by inviting additional family members to participate who have not yet joined the BCFR. Maintaining and enhancing the core infrastructure facilitates a broad research agenda that includes a wide range of studies, such as examination of risk factors and cancer-related outcomes including risk and survival, gene discovery, investigation of novel behavioral intentions and risk communication programs, and cancer prevention trials among at-risk family members.