Mayo Mammography Health Study

Lead Contact and/or Principal Investigator (PI):

Funded Since: 2003
Funding Source: Mayo Clinic Cancer Center and NCI Extramural Program (Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences)
Year(s) of Enrollment: 2003-2006
Study Website: http://mayoresearch.mayo.edu/mayo/research/mammohealthstudyExternal Web Site Policy

The Mayo Mammography Health Study (MMHS) is a prospective cohort comprised of 19,924 women ages 35 and over, living in the tri-state region surrounding the Mayo Clinic (Minnesota, Iowa, and Wisconsin), without a history of breast cancer, who were scheduled for a screening mammogram at the Mayo Clinic between October 2003 and September 2006. All women had a 4-view screening mammogram at the time of enrollment and completed a self-administered questionnaire. A majority of the cohort (14,579) also had blood available from their routine blood work, which was saved as a source of buffy coat, or DNA, and plasma. A total of 2,291 cohort participants had a history of cancer other than of the breast. Therefore, the investigators defined a healthy cohort as the 17,633 women who were free of a history of any cancer at baseline (excluding non-melanoma skin cancer).

Follow-up for all incident cancers is performed annually using linkages to Mayo Clinic databases and the tri-state cancer registries. For those participants who have moved out of the region, the investigators use self-report, with pathology confirmation. As of September 2009, the total number of incident cancers in the healthy cohort was 611, of which 227 were breast cancers.

The MMHS was designed to answer questions surrounding mammographic breast density, a strong risk factor for breast cancer. Analyses to date have used a case-cohort approach, in which the investigators have identified a random sample of 2,300 women from the cohort at baseline. As a part of the case-cohort design, all incident breast cancer cases are included. Mammographic density has been estimated using the Cumulus program on the enrollment mammogram from all participants in the case-cohort. Acquisition of tumor blocks and formation of tumor microarrays is under way for all invasive breast cancer cases.

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