Cohort Consortium Members
Shanghai Men's Health Study (SMHS): Cohort Study of Cancer- Inhibitory Factors in Men
Lead Contact and/or Principal Investigator (PI):
- Xiao O. Shu, M.D., Ph.D.
Vanderbilt University Medical Center
Funded Since: 2001
Funding Source: NCI Extramural Program (Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences; CA082729)
Year(s) of Enrollment: 2001-2006
The Shanghai Men’s Health Study (SMHS) is a population-based cohort study that is being conducted in parallel with the Shanghai Women’s Health Study (SWHS) at Vanderbilt University in collaboration with the Shanghai Cancer Institute. This research is to establish a cohort of adult men in Shanghai for a long-term epidemiological study of cancer and other chronic diseases, with a focus on identifying modifiable protective dietary factors for cancers.
The main objectives of the study are to:
- Identify dietary and other lifestyle factors that prevent the development of cancer and other chronic diseases, and
- Establish resources, including both survey information and biological samples, for investigation of the genetic contributions and molecular mechanisms related to etiology of cancer and other chronic diseases.
A total of 61,500men who resided in 8 study communities and who were between 40 and 74 years of age were recruited into the study between July 1, 2001, and June 30, 2006, with response rates of 74 percent for the in-person baseline survey, 75 percent for blood sample collection, and 89 percent for urine sample collection. Among the subjects who did not provide a blood sample, 56 percent donated a buccal cell sample. About 50 percent of SMHS participants are married to participants of the SWHS, providing a unique opportunity to study genetic and environmental exposures related to risk of cancer and other chronic diseases among married couples.
Exposure data were collected through in-person interviews with a rigorous quality control protocol and using a structured questionnaire, which included a validated food frequency questionnaire and a physical activity questionnaire. Two food frequency questionnaires are administered in person two years apart with a more than 82 percent response rate achieved to date. The cohort is being followed up via biennial in‑person surveys and record linkage with the Shanghai Tumor Registry and Shanghai Vital Statistics database. Exposure information is updated, and new chronic disease occurrences are ascertained during the in-person follow-up surveys. Cancer cases and deaths are verified by in‑home visits and review of medical charts or death certificates.