Integrated Chemical List (Past Initiative)
Some Long Island breast cancer advocates, who have been interested in the Long Island Breast Cancer Study Project (LIBCSP), submitted a list of chemicals and other agents of concern to them as possible causes of breast cancer. Many of the agents are already included in the LIBCSP. The table lists both the agents of community interest and those included in the LIBCSP, and is called the Integrated Chemical List.
The table on the Integrated Chemical List was compiled by Ruth Allen, Ph.D., of the Environmental Protection Agency (EPA), and points to various sources of further information on the toxicology and carcinogenicity of the agents. The LIBCPS also appreciates the help of Richard Hill, Ph.D., of EPA, who coordinated obtaining the various databases for the effort. The table aggregates much information on the agents, but is not a comprehensive reference. You may be aware of other sources, and links to some are provided.
Tips on using the Integrated Chemical List table:
- Under Headings is listed the sources of information on the agents (e.g., NTP -- National Toxicology Program).
- The Description box provides information about the source, and links to the sources' Web sites to access information on the agent of interest.
- Quickly search our Web site by the agent's name, or the CAS number, by choosing "Find..." from the "Edit" menu of your browser (or typing Ctrl+F). Insert search words or numbers.
- An agent may be listed under a synonym: One way to search for synonyms is to use CambridgeSoft ChemFinder. ChemFinder requires registration, but the service is free. This Web-based dictionary will help you obtain synonyms, and perhaps more importantly, the Chemical Abstract Service (CAS) registry number for the agent. The CAS number is a universally recognized identification number which is included in the Integrated Chemical List to help you identify agents. The external link to ChemFinder is provided as a service to our users; the company is not affiliated with the National Cancer Institute (NCI).
- The EPA Regulatory Status heading mostly captures information on whether a pesticide has been granted a license, or registration, to permit its distribution, sale, and use according to specified requirements. EPA is required by law to review and reregister pesticides that were initially registered before November 1984. Reregistration Eligibility Decision (RED) indicates EPA has reviewed and reregistered the pesticide. Canceled means that the pesticide is no longer registered.
The Headings are:
|chemical name/ CAS#/ Use/ EPA Regulatory Status||
The National Toxicology Program designs, conducts, and interprets animal assays for toxicity/carcinogenicity. NTP is part of the National Institute of Environmental Health Sciences (NIEHS), U.S. Department of Health and Human Services (DHHS).
= information available in NTP
The Agency for Toxic Substances and Disease Registry produces fact sheets, called ToxFAQs, about the adverse effects of exposure to many hazardous substances. ATSDR is part of DHHS.
= fact sheet available
Program on Breast Cancer and Environmental Risk Factors in New York State provides fact sheets and other information on risk for breast cancer. Note: The BCERF program closed on 3/31/10. Archived research and educational materials can be accessed at http://ecommons.library.cornell.edu/handle/1813/14300.
= fact sheet available
Integrated Risk Information System database provides information on human health effects that may result from exposure to various chemicals. IRIS was developed by EPA to provide its staff consistent information on chemical substances for risk assessments, decision making, and regulatory activities.
= information available in IRIS
Toxic Release Inventory database provides information on chemical releases and waste management activities, including state fact sheets that summarize annual release data by state. TRI is published by EPA.
= information available in TRI
Genetic Activity Profile database provides toxicity data on chemical agents from EPA priority chemical groups, and the International Agency for Research on Cancer Monographs. The database includes short-term test results abstracted from 8000 references on genetic toxicity.
= information available in GAP
|IARC Carcinogenicity Assessment||
The International Agency for Research on Cancer produces the IARC Monographs Database on Carcinogenic Risks to Humans. Information is summarized on agents evaluated based on weight of evidence for carcinogenicity. Readers may refer to the Monographs for background information on type(s) of cancer implicated or cited in the review.
= agent is classified
|EPA Carcinogenicity Assessment||
EPA performs its own carcinogenicity assessments and classifies the likehood of agents being human carcinogens based on weight of evidence. The classification system is described.
= agent is classified
|LIBCSP||Agents tested for in the Long Island Breast Cancer Study Project are indicated by , along with the source of the agent (e.g., blood, water, soil)|