Some Long Island breast cancer advocates, who have been interested in
the Long Island Breast Cancer Study Project (LIBCSP), submitted a list
of chemicals and other agents of concern to them as possible causes of
breast cancer. Many of the agents are already included in the LIBCSP.
The table lists both the agents of community interest and those included
in the LIBCSP, and is called the Integrated
Chemical List.
The table on the Integrated Chemical List
was compiled by Ruth Allen, Ph.D., of the Environmental Protection Agency
(EPA), and points to various sources of further information on the toxicology
and carcinogenicity of the agents. The LIBCPS also appreciates the help
of Richard Hill, Ph.D., of EPA, who coordinated obtaining the various
databases for the effort. The table aggregates much information on the
agents, but is not a comprehensive reference. You may be aware of other
sources, and links to some are provided.
Tips on using the Integrated Chemical
List table:
- Under Headings is listed the sources of information
on the agents (e.g., NTP -- National Toxicology Program).
- The Description box provides information about the
source, and links to the sources' Web sites to access information on
the agent of interest.
- Quickly search our Web site by the agent's name,
or the CAS number, by choosing "Find..." from the "Edit"
menu of your browser (or typing Ctrl+F). Insert search words or numbers.
- An agent may be listed under a synonym: One way to search
for synonyms is to use CambridgeSoft
ChemFinder. ChemFinder requires registration, but the service is
free. This Web-based dictionary will help you obtain synonyms, and perhaps
more importantly, the Chemical Abstract Service (CAS) registry number
for the agent. The CAS number is a universally recognized identification
number which is included in the Integrated Chemical List to help you
identify agents. The external link to ChemFinder is provided as a service
to our users; the company is not affiliated with the National Cancer
Institute (NCI).
- The EPA Regulatory Status heading mostly captures
information on whether a pesticide has been granted a license, or registration,
to permit its distribution, sale, and use according to specified requirements.
EPA is required by law to review and reregister
pesticides that were initially registered before November 1984. Reregistration
Eligibility Decision (RED) indicates EPA has reviewed and reregistered
the pesticide. Canceled means that the pesticide is no longer
registered. EPA Pesticide Programs Web site: http://www.epa.gov/pesticides/
The Headings are:
| Headings |
Description |
| chemical name/ CAS#/ Use/ EPA
Regulatory Status |
- name of the agent
- Chemical Abstract Service (CAS) registry number
(universal identification number to help identify agents with
synonyms)
- use of the agent
- EPA Regulatory Status - registration, or license,
status of the agent. See Pesticide
Registration and Reregistration.
|
| NTP |
The National
Toxicology Program designs, conducts, and interprets animal
assays for toxicity/carcinogenicity. NTP is part of the National
Institute of Environmental Health Sciences (NIEHS), U.S. Department
of Health and Human Services (DHHS).
= information available in NTP
|
| ATSDR |
The Agency
for Toxic Substances and Disease Registry produces fact sheets,
called ToxFAQs, about the adverse effects of exposure to many hazardous
substances. ATSDR is part of DHHS.
=
fact sheet available |
| BCERF |
Program
on Breast Cancer and Environmental Risk Factors in New York
State provides fact sheets and other information on risk for breast
cancer.
=
fact sheet available |
| IRIS |
Integrated
Risk Information System database provides information on human
health effects that may result from exposure to various chemicals.
IRIS was developed by EPA to provide its staff consistent information
on chemical substances for risk assessments, decision making, and
regulatory activities.
=
information available in IRIS |
| TRI |
Toxic
Release Inventory database provides information on chemical
releases and waste management activities, including state fact sheets
that summarize annual release data by state. TRI is published by
EPA.
=
information available in TRI |
| GAP |
Genetic
Activity Profile database provides toxicity data on chemical
agents from EPA priority chemical groups, and the International
Agency for Research on Cancer Monographs. The database includes
short-term test results abstracted from 8000 references on genetic
toxicity.
=
information available in GAP |
| IARC Carcinogenicity Assessment
|
The International Agency for Research on Cancer
produces the IARC
Monographs Database on Carcinogenic Risks to Humans. Information
is summarized on agents evaluated based on weight of evidence for
carcinogenicity. The classification
system is described. Readers may refer to the Monographs for
background information on type(s) of cancer implicated or cited
in the review.
=
agent is classified |
| EPA Carcinogenicity Assessment |
EPA performs its own carcinogenicity
assessments and classifies the likehood of agents being human
carcinogens based on weight of evidence. The classification system
is described.
=
agent is classified |
| LIBCSP |
Agents tested for in the Long Island Breast Cancer
Study Project are indicated by ,
along with the source of the agent (e.g., blood, water, soil) |
Access the Integrated
Chemical List
|
