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Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative

Tools Created by GAME-ON Investigators

GAME-ON investigators are developing tools that can be used by the scientific community to further their research. More tools may be added to this page over time.

• Cancer Survivors Index

  The Cancer Survival Index is a web-based resource that allows users to explore genes and gene sets to identify those whose expression is correlated with overall survival in breast cancer and in its defined molecular subtypes.

• FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs.

  The R/Bioconductor software package enables the identification of candidate functional SNPs by integrating information from tagSNP locations, lists of linked SNPs from the 1000 genomes project and locations of chromatin features which may have functional significance.

  FunciSNP is available from Bioconductor.

• GeneSigDB - a curated database of gene expression signatures.

  GeneSigDB is a searchable resource providing access to gene signatures that have been manually curated from the literature and mapped to standard gene identifiers using a defined annotation pipeline. These standardized gene signatures facilitate the use of gene set enrichment methods and the search for common features among published datasets.

• GxEscan: software to detect GxE interactions in a genome-wide association study. GxEscan implements a variety of exhaustive and 2-step testing approaches. GxEscan is available for download from the University of Southern California.

Related Resources

• Cancer Epidemiology Consortia
  List of national and international cancer epidemiology research consortia that receive some support from EGRP. Cancer epidemiology consortia provide unique opportunities for advancing cancer research by virtue of the large sample sizes achieved through collaboration among multiple studies, and the synergy that results from the interdisciplinary expertise of their membership.
• Genomic Resources
  Compilation of websites containing genomic datasets, information about genotyping and sequencing centers, NCI- and NIH-sponsored networks and programs, and analytical and interpretative tools for genomic data.
• Integrative Cancer Biology Program
  This Program, managed by NCI's Division of Cancer Biology, focuses on the analysis of cancer as a complex biological system. A cornerstone of the program is the development and implementation of computational models of processes relevant to cancer prevention, diagnostics, and therapeutics.
• Mouse Models of Human Cancers Consortium
  This site, mainted by NCI, introduces aspects of the history of animal research, animal husbandry, techniques for breeding and characterizing animal models, standards for animal use, and sources of animal models.
• Specialized Programs of Research Excellence (SPOREs)
  NCI SPORE grants involve both basic and clinical/applied scientists and support projects that will result in new and diverse approaches to the prevention, early detection, diagnosis and treatment of human cancers. The program is open to additional organ system translational research, including research in less common cancers.
• Tumor Microenvironment Network
  NCI's Tumor Microenvironment initiative focuses on expanding understanding of the role of the tumor microenvironment in cancer initiation, progression and metastases.