Research Highlights from EGRP Grantees - 2014
EGRP staff nominated and voted for manuscripts published in 2014 by EGRP grantees that were deemed to have the greatest potential scientific and/or public health impact. The final selections for EGRP's 2014 Research Highlights are presented below.
EGRP funds research in human populations to understand determinants of cancer occurrence and outcomes. The Program is the largest funder of cancer epidemiology grants nationally and worldwide, supporting approximately 300 grants and cooperative agreements annually. View a full list of active EGRP grants.
The research featured below was funded in full or in part by EGRP:
Lange JM, Takashima JR, Peterson SM, Kalapurakal JA, Green DM, Breslow NE. Breast cancer in female survivors of Wilms tumor: a report from the National Wilms Tumor late effects study. Cancer. 2014 Dec 1;120(23):3722-30.
This research was funded by an EGRP grant to Wendy M. Leisenring, Sc.D., of the Fred Hutchinson Cancer Research Center.
Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, et al. Breast-cancer risk in families with mutations in PALB2. N Engl J Med. 2014 Aug 7;371(6):497-506.
This research was funded in part by EGRP grants to Irene L. Andrulis, Ph.D., of Cancer Care Ontario; Jonine L. Bernstein, Ph.D., of the Memorial Sloan-Kettering Cancer Center; Saundra S. Buys, M.D., of the University of Utah; Silvia Casadei, Ph.D., University of Washington; Fergus J. Couch, Ph.D., of the Mayo Clinic Rochester; Mary B. Daly, M.D., Ph.D., of the Fox Chase Cancer Center; John L. Hopper, Ph.D., of the University of Melbourne; Esther M. John, Ph.D., of the Cancer Prevention Institute of California; Mary-Claire King, Ph.D., of the University of Washington; Mary Beth Terry, Ph.D., Columbia University Health Sciences; Thomas Walsh, M.D., of the University of Washington; and Jeffrey N. Weitzel, M.D., of the Beckman Research Institute at City of Hope.
Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, et al. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Nat Commun. 2014 Oct 20;5:5260.
This research was funded in part by EGRP grants to Christopher A. Haiman, Sc.D., of the University of Southern California; Esther M. John, Ph.D., of the Cancer Preventon Institute of California; Laurence N. Kolonel, M.D., Ph.D., of the University of Hawaii at Manoa; Loic Le Marchand, M.D., Ph.D., of the University of Hawaii at Manoa; and Elad Ziv, M.D., of the University of California, San Francisco.
This research is based on data from the Breast Cancer Family Registry, which is supported in part by EGRP. Multiple EGRP-funded investigators participated in this consortium.
Sieh W, Rothstein JH, McGuire V, Whittemore AS. The role of genome sequencing in personalized breast cancer prevention. Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2322-7.
This research was funded in part by an EGRP grant to Joseph H. Rothstein, Ph.D., and Alice Whittemore, Ph.D., both of Stanford University.
Kwan ML, John EM, Caan BJ, Lee VS, Bernstein L, Cheng I, et al. Obesity and mortality after breast cancer by race/ethnicity: the California Breast Cancer Survivorship Consortium. Am J Epidemiol. 2014 Jan 1;179(1):95-111.
This research was funded in part by EGRP grants to Leslie Bernstein, Ph.D., of the Beckman Research Institute at City of Hope; Bette J. Caan, Dr.P.H., of the Kaiser Foundation Research Institute; Esther M. John, Ph.D., of the Cancer Prevention Institute of California; and Laurence N. Kolonel, M.D., Ph.D., of the University of Hawaii at Manoa.
Rositch AF, Nowak RG, Gravitt PE. Increased age and race-specific incidence of cervical cancer after correction for hysterectomy prevalence in the United States from 2000 to 2009. Cancer. 2014 Jul 1;120(13):2032-8.
This research was funded in part by an EGRP grant to Patti Gravitt, Ph.D., of Johns Hopkins University.
Kanchi KL, Johnson KJ, Lu C, McLellan MD, Leiserson MD, Wendl MC, et al. Integrated analysis of germline and somatic variants in ovarian cancer. Nat Commun. 2014;5:3156.
This research was funded in part by an EGRP grant to Li Ding, Ph.D., of The Genome Institute at Washington University School of Medicine.
Farzan SF, Karagas MR, Christensen BC, Li Z, Kuriger JK, Nelson HH; New Hampshire Skin Cancer Study. RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer.. PLoS One. 2014 Apr 3;9(4):e93602.
This research was funded in part by EGRP grants to Brock C. Christensen, Ph.D. and Margaret R. Karagas, Ph.D., both of Dartmouth College, and Heather H. Nelson, Ph.D., of the University of Minnesota.