Research Highlights from EGRP Grantees - 2015

EGRP staff nominated and voted for manuscripts published in 2015 by EGRP grantees that were deemed to have the greatest potential scientific and/or public health impact. The final selections for EGRP's 2015 Research Highlights are presented below.

EGRP funds research in human populations to understand determinants of cancer occurrence and outcomes. The Program is the largest funder of cancer epidemiology grants nationally and worldwide, supporting more than 250 grants and cooperative agreements annually. View a full list of active EGRP grantsExternal Web Site Policy.

The research featured below was funded in full or in part by EGRP:

Breast Cancer

Association of Type and Location of BRCA1 and BRCA2 Mutations with Risk of Breast and Ovarian Cancer

Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, et al. Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancerExternal Web Site Policy. JAMA. 2015 Apr 7;313(13):1347-61.

This research was funded by EGRP grants to Mary B. Daly, M.D., Ph.D., F.A.C.P., of Fox Chase Cancer Center; Esther M. John, Ph.D., of the Cancer Prevention Institute of California; Susan L. Neuhausen, Ph.D., of City of Hope/Beckman Research Institute; Boris Pasche, M.D., Ph.D., of the University of Alabama at Birmingham; and Timothy R. Rebbeck, Ph.D., of the University of Pennsylvania; and Mary Beth Terry, Ph.D., of Columbia University Health Sciences.

Breastfeeding, PAM50 Tumor Subtype, and Breast Cancer Prognosis and Survival

Kwan ML, Bernard PS, Kroenke CH, Factor RE, Habel LA, Weltzien EK, et al. Breastfeeding, PAM50 tumor subtype, and breast cancer prognosis and survivalExternal Web Site Policy. J Natl Cancer Inst. 2015 Apr 28;107(7).

This research was funded by EGRP grants to Bette J. Caan, Dr.P.H., of the Kaiser Foundation Research Center and Lawrence H. Kushi, Sc.D., of the Kaiser Foundation Research Center.

Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer

Couch FJ, Hart SN, Sharma P, Toland AE, Wang X, Miron P, et al. Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancerExternal Web Site Policy. J Clin Oncol. 2015 Feb 1;33(4):304-11.

This research was funded by an EGRP grant to Fergus J. Couch, Ph.D., of the Mayo Clinic Rochester.


Colorectal Cancer

Association of Aspirin and NSAID Use with Risk of Colorectal Cancer According to Genetic Variants

Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, White E, et al. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variantsExternal Web Site Policy. JAMA. 2015 Mar 17;313(11):1133-42.

This research was funded by EGRP grants to Steven Gallinger, M.D., M.Sc., of Cancer Care Ontario; John L. Hopper, Ph.D., of the University of Melbourne; Polly A. Newcomb, Ph.D., M.P.H., of the Fred Hutchinson Cancer Research Center; Shuji Ogino, M.D., Ph.D., M.S., of the Dana Farber Cancer Institute; Ulrike Peters, Ph.D., M.P.H., of the Fred Hutchinson Cancer Research Center; Martha Slattery, Ph.D., M.P.H., of the University of Utah; Meir Stampfer, M.D., Dr.P.H., of Brigham and Women's Hospital; and Walter C. Willett, M.D., Dr.P.H., of Harvard School of Public Health.


Diet

Fat, Fibre and Cancer Risk in African Americans and Rural Africans

O'Keefe SJ, Li JV, Lahti L, Ou J, Carbonero F, Mohammed K, et al. Fat, fibre and cancer risk in African Americans and rural AfricansExternal Web Site Policy. Nat Commun. 2015 Apr 28;6:6342.

This research was funded by an EGRP grant to Stephen O'Keefe, M.D., M.Sc., of the University of Pittsburgh.

Diet and Perceptions Change with Supermarket Introduction in a Food Desert, But Not Because of Supermarket Use

Dubowitz T, Ghosh-Dastidar M, Cohen DA, Beckman R, Steiner ED, Hunter GP, et al. Diet and perceptions change with supermarket introduction in a food desert, but not because of supermarket useExternal Web Site Policy. Health Aff (Millwood). 2015 Nov 1;34(11):1858-68.

This research was funded by an EGRP grant to Tamara Dubowitz, M.Sc., Ph.D., of The Rand Corporation.


Endometrial

Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome

Dashti SG, Chau R, Ouakrim DA, Buchanan DD, Clendenning M, Young JP, et al. Female hormonal factors and the risk of endometrial cancer in Lynch SyndromeExternal Web Site Policy. JAMA. 2015 Jul 7;314(1):61-71.

This research was funded by EGRP grants to Steven Gallinger, M.D., M.Sc., of Cancer Care Ontario; Robert W. Haile, D.M.D., of Stanford University; John L. Hopper, Ph.D., of the University of Melbourne; Loic Le Marchand, M.D., Ph.D., of the University of Hawaii at Manoa; Polly A. Newcomb, Ph.D., M.P.H., of the Fred Hutchinson Cancer Research Center; and Stephen N. Thibodeau, Ph.D., of the Mayo Clinic Rochester.


Next-Generation Sequencing

Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

Beltran H, Eng K, Mosquera JM, Sigaras A, Romanel A, Rennert H. Whole-exome sequencing of metastatic cancer and biomarkers of treatment responseExternal Web Site Policy. JAMA Oncol. 2015 Jul;1(4):466-74.

This research was funded by an EGRP grant to Mark Rubin, M.D., of Cornell University.

Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth

Mody RJ, Wu YM, Lonigro RJ, Cao X, Roychowdhury S, Vats P, et al. Integrative clinical sequencing in the management of refractory or relapsed cancer in youthExternal Web Site Policy. JAMA. 2015 Sep 1;314(9):913-25.

This research was funded by a grant to Arul M. Chinnaiyan, M.D., Ph.D., at the University of Michigan, as part of the Clinical Sequencing Exploratory Research (CSER) program, a consortium supported by EGRP and the National Human Genome Research Institute (NHGRI).


Lung Cancer

CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis--A Meta-Analysis

Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, et al. CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysisExternal Web Site Policy. J Natl Cancer Inst. 2015 Apr 14;107(5).

This research was funded by EGRP grants to Christopher I. Amos, Ph.D., of the University of Texas/MD Anderson Cancer Center; David C. Christiani, M.D., M.P.H., of Harvard School of Public Health; David J. Hunter, M.B.B.S., Sc.D., M.P.H., of Harvard School of Public Health; Margaret R. Spitz, M.D., M.P.H., of Baylor College of Medicine; John K. Wiencke, Ph.D., of the University of California, San Francisco; Margaret R. Wrensch, Ph.D., of the University of California, San Francisco; and Zuo-Feng Zhang, M.D., Ph.D., Children's Hospital Los Angeles.


Pancreatic Cancer

Common Variation at 2p13.3, 3q29, 7p13 and 17q25.1 Associated with Susceptibility to Pancreatic Cancer

Childs EJ, Mocci E, Campa D, Bracci PM, Gallinger S, Goggins M, et al. Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancerExternal Web Site Policy. Nat Genet. 2015 Aug;47(8):911-6.

This research was funded by EGRP grants to Paul J. Brennan, Ph.D., M.Sc., of the International Agency for Research on Cancer; Paige M. Bracci, Ph.D., M.P.H., of the University of California, San Francisco; Alison P. Klein, Ph.D., of Johns Hopkins University; Gloria M. Petersen, Ph.D., of the Mayo Clinic Rochester; and Harvey A. Risch, M.D., Ph.D., of Yale University.

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