Research Highlights from EGRP Grantees - 2014

EGRP staff nominated and voted for manuscripts published in 2014 by EGRP grantees that were deemed to have the greatest potential scientific and/or public health impact. The final selections for EGRP's 2014 Research Highlights are presented below.

EGRP funds research in human populations to understand determinants of cancer occurrence and outcomes. The Program is the largest funder of cancer epidemiology grants nationally and worldwide, supporting approximately 300 grants and cooperative agreements annually. View a full list of active EGRP grants.External Web Site Policy

The research featured below was funded in full or in part by EGRP:

Breast Cancer

Breast Cancer in Female Survivors of Wilms Tumor: A Report From the National Wilms Tumor Late Effects Study

Lange JM, Takashima JR, Peterson SM, Kalapurakal JA, Green DM, Breslow NE. Breast cancer in female survivors of Wilms tumor: a report from the National Wilms Tumor late effects studyExternal Web Site Policy. Cancer. 2014 Dec 1;120(23):3722-30.

This research was funded by an EGRP grant to Wendy M. Leisenring, Sc.D., of the Fred Hutchinson Cancer Research Center.

Breast-Cancer Risk in Families with Mutations in PALB2

Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, et al. Breast-cancer risk in families with mutations in PALB2External Web Site Policy. N Engl J Med. 2014 Aug 7;371(6):497-506.

This research was funded in part by EGRP grants to Irene L. Andrulis, Ph.D., of Cancer Care Ontario; Jonine L. Bernstein, Ph.D., of the Memorial Sloan-Kettering Cancer Center; Saundra S. Buys, M.D., of the University of Utah; Silvia Casadei, Ph.D., University of Washington; Fergus J. Couch, Ph.D., of the Mayo Clinic Rochester; Mary B. Daly, M.D., Ph.D., of the Fox Chase Cancer Center; John L. Hopper, Ph.D., of the University of Melbourne; Esther M. John, Ph.D., of the Cancer Prevention Institute of California; Mary-Claire King, Ph.D., of the University of Washington; Mary Beth Terry, Ph.D., Columbia University Health Sciences; Thomas Walsh, M.D., of the University of Washington; and Jeffrey N. Weitzel, M.D., of the Beckman Research Institute at City of Hope.

Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25

Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, et al. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25External Web Site Policy. Nat Commun. 2014 Oct 20;5:5260.

This research was funded in part by EGRP grants to Christopher A. Haiman, Sc.D., of the University of Southern California; Esther M. John, Ph.D., of the Cancer Preventon Institute of California; Laurence N. Kolonel, M.D., Ph.D., of the University of Hawaii at Manoa; Loic Le Marchand, M.D., Ph.D., of the University of Hawaii at Manoa; and Elad Ziv, M.D., of the University of California, San Francisco.

This research is based on data from the Breast Cancer Family Registry, which is supported in part by EGRP. Multiple EGRP-funded investigators participated in this consortium.

The Role of Genome Sequencing in Personalized Breast Cancer Prevention

Sieh W, Rothstein JH, McGuire V, Whittemore AS. The role of genome sequencing in personalized breast cancer preventionExternal Web Site Policy. Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2322-7.

This research was funded in part by an EGRP grant to Joseph H. Rothstein, Ph.D., and Alice Whittemore, Ph.D., both of Stanford University.

Obesity and Mortality After Breast Cancer by Race/Ethnicity: The California Breast Cancer Survivorship Consortium

Kwan ML, John EM, Caan BJ, Lee VS, Bernstein L, Cheng I, et al. Obesity and mortality after breast cancer by race/ethnicity: the California Breast Cancer Survivorship ConsortiumExternal Web Site Policy. Am J Epidemiol. 2014 Jan 1;179(1):95-111.

This research was funded in part by EGRP grants to Leslie Bernstein, Ph.D., of the Beckman Research Institute at City of Hope; Bette J. Caan, Dr.P.H., of the Kaiser Foundation Research Institute; Esther M. John, Ph.D., of the Cancer Prevention Institute of California; and Laurence N. Kolonel, M.D., Ph.D., of the University of Hawaii at Manoa.


Cervical Cancer

Increased Age and Race-Specific Incidence of Cervical Cancer After Correction for Hysterectomy Prevalence in The United States From 2000 To 2009

Rositch AF, Nowak RG, Gravitt PE. Increased age and race-specific incidence of cervical cancer after correction for hysterectomy prevalence in the United States from 2000 to 2009External Web Site Policy. Cancer. 2014 Jul 1;120(13):2032-8.

This research was funded in part by an EGRP grant to Patti Gravitt, Ph.D., of Johns Hopkins University.


Ovarian Cancer

Integrated Analysis of Germline and Somatic Variants in Ovarian Cancer

Kanchi KL, Johnson KJ, Lu C, McLellan MD, Leiserson MD, Wendl MC, et al. Integrated analysis of germline and somatic variants in ovarian cancerExternal Web Site Policy. Nat Commun. 2014;5:3156.

This research was funded in part by an EGRP grant to Li Ding, Ph.D., of The Genome Institute at Washington University School of Medicine.


Skin Cancer

RNASEL and MIR146A SNP-SNP Interaction as a Susceptibility Factor for Non-Melanoma Skin Cancer

Farzan SF, Karagas MR, Christensen BC, Li Z, Kuriger JK, Nelson HH; New Hampshire Skin Cancer Study. RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer.External Web Site Policy. PLoS One. 2014 Apr 3;9(4):e93602.

This research was funded in part by EGRP grants to Brock C. Christensen, Ph.D. and Margaret R. Karagas, Ph.D., both of Dartmouth College, and Heather H. Nelson, Ph.D., of the University of Minnesota.

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