Research Highlights from EGRP Grantees - 2013

EGRP staff nominated and voted for manuscripts published in 2013 by EGRP grantees that were deemed to have the greatest potential scientific and/or public health impact. The final 10 selections for EGRP's 2013 Research Highlights are presented below.

EGRP funds research in human populations to understand determinants of cancer occurrence and outcomes. EGRP is the largest funder of cancer epidemiology grants nationally and worldwide, supporting more than 400 grants and cooperative agreements annually. View a full list of active EGRP grantsExternal Web Site Policy.

The research featured below was funded in full or in part by EGRP:

Breast Cancer

Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk

Liu Y, Colditz GA, Rosner B, Berkey CS, Collins LC, Schnitt SJ, et al. Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer riskExternal Web Site Policy. J Natl Cancer Inst. 2013 Oct 16;105(20):1571-8.

This research was funded in part by EGRP grants to Walter Willett, M.D., M.P.H., Dr.P.H., of Harvard School of Public Health.

High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis

Kroenke CH, Kwan ML, Sweeney C, Castillo A, Caan BJ. High- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosisExternal Web Site Policy. J Natl Cancer Inst. 2013 May 1;105(9):616-23.

This research was funded by an EGRP grant to Bette Caan, Dr.P.H., of the Kaiser Permanente Division of Research.

Onset of Breast Development in a Longitudinal Cohort

Biro FM, Greenspan LC, Galvez MP, Pinney SM, Teitelbaum S, Windham GC, et al. Onset of breast development in a longitudinal cohortExternal Web Site Policy. Pediatrics. 2013 Dec;132(6):1019-27.

This research was funded as part of the Breast Cancer and the Environment Research Program (BCERP), a consortium supported by EGRP and the National Institute of Environmental and Health Sciences (NIEHS). Learn more about the BCERP.

Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years

Li CI, Daling JR, Tang MT, Haugen KL, Porter PL, Malone KE. Use of antihypertensive medications and breast cancer risk among women aged 55 to 74 yearsExternal Web Site Policy. JAMA Intern Med. 2013 Sep 23;173(17):1629-37.

The research was supported in part by an EGRP grant to Christopher Li, M.D., Ph.D., of the Fred Hutchinson Cancer Research Center.


Cancer Mortality

Association of Nut Consumption with Total and Cause-Specific Mortality

Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, et al. Association of nut consumption with total and cause-specific mortalityExternal Web Site Policy. N Engl J Med. 2013 Nov 21;369(21):2001-11.

This research was funded in part by grants to Meir J. Stampfer, Dr.P.H., M.D., of Brigham and Women's Hospital and Charles S. Fuchs of the Dana-Farber Cancer Institute.


Leukemia

Genome-Wide Association Study Identifies Multiple Risk Loci for Chronic Lymphocytic Leukemia

Berndt SI, Skibola CF, Joseph V, Camp NJ, Nieters A, Wang Z, et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemiaExternal Web Site Policy. Nat Genet. 2013 Aug;45(8):868-76.

This research was funded in part by grants to James Cerhan, M.D., Ph.D., of the Mayo Clinic, Rochester; Chistine Skibola, Ph.D., of the University of Alabama, Birmingham; Nicola J. Camp, Ph.D., of the University of Utah; Brenda M. Birmann, Sc.D., of Brigham and Women's Hospital; and Susan L. Slager, Ph.D., of the Mayo Clinic, Rochester.

The Use of Computed Tomography in Pediatrics and the Associated Radiation Exposure and Estimated Cancer Risk

Miglioretti DL, Johnson E, Williams A, Greenlee RT, Weinmann S, Solberg LI, et al. The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer riskExternal Web Site Policy. JAMA Pediatr. 2013 Aug 1;167(8):700-7.

This research was funded in part by an EGRP grant to Rebecca Smith-Bindman, M.D., of the University of California, San Francisco.


Lung Cancer

Hierarchical Modeling Identifies Novel Lung Cancer Susceptibility Variants in Inflammation Pathways Among 10,140 Cases and 11,012 Controls

Brenner DR, Brennan P, Boffetta P, Amos CI, Spitz MR, Chen C, et al. Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controlsExternal Web Site Policy. Hum Genet. 2013 May;132(5):579-89.

This research was funded in part by grants to Christopher I. Amos, Ph.D., of Dartmouth College and Margaret R. Spitz, M.D., M.P.H., of Baylor College of Medicine.


Ovarian Cancer

GWAS Meta-Analyses and Replication Identifies Three New SUsceptibility Loci for Ovarian Cancer

Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancerExternal Web Site Policy. Nat Genet. 2013 Apr;45(4):362-70, 370e1-2.

This research was funded in part by grants to Ellen L. Goode, Ph.D., of the Mayo Clinic, Rochester; Catherine Phelan, Ph.D., M.D., M.M.S, and Thomas A. Sellers, Ph.D., of the H. Lee Moffitt Cancer Center and Research Institute; and Wei Zheng, Ph.D., M.D., M.P.H., of Vanderbilt University Medical Center.


Skin Cancer

The Impact of 3'UTR Variants on Differential Expression of Candidate Cancer Susceptibility Genes

Skeeles LE, Fleming JL, Mahler KL, Toland AE. The impact of 3'UTR variants on differential expression of candidate cancer susceptibility genesExternal Web Site Policy. PLoS One. 2013;8(3):e58609.

This research was funded in part by an EGRP grant to Amanda E. Toland, Ph.D., of The Ohio State University.

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