2010-2011 Research Highlights
The Epidemiology and Genomics Research Program (EGRP) funds research in human populations to understand the causes of cancer and related outcomes.
The research featured below was funded in full or in part by EGRP. The featured research was nominated by extramural investigators and selected by EGRP Program Staff based on scientific merit, innovation, and/or potential public health impact.
EGRP is the largest funder of cancer epidemiology grants nationally and worldwide, supporting more than 300 grants and cooperative agreements annually. View a full list of active EGRP grants.
- Adding Common Genetic Variants to Breast Cancer Risk Models Offers Only Small Benefit (Mar 2010)
- Circadian Rhythm Gene Variants May Affect Breast Cancer Risk (Feb 2010)
- Neural Network Model Effectively Discriminates Between Malignant and Benign Breast Lesions (Jul 2010)
- Young Girls Attaining Puberty at Earlier Ages; Investigators Examine Link to Environmental Exposures (Sep 2010)
- Older, Early-Stage Breast Cancer Patients Have Better Survival With Lumpectomy Plus Radiation Rather Than Mastectomy (Feb 2011)
- Genome-Wide Association Study Identifies New Susceptibility Locus for Follicular Lymphoma (Aug 2010)
Adding Common Genetic Variants to Breast Cancer Risk Models Offers Only Small Benefit
Wacholder S, Hartge P, Prentice R, Garcia-Closas M, Feigelson HS, Diver WR, Thun MJ, Cox DG, Hankinson SE, Kraft P, Rosner B, Berg CD, Brinton LA, Lissowska J, Sherman ME, Chlebowski R, Kooperberg C, Jackson RD, Buckman DW, Hui P, Pfeiffer R, Jacobs KB, Thomas GD, Hoover RN, Gail MH, Chanock SJ, Hunter DJ.. Performance of common genetic variants in breast-cancer risk models. N Engl J Med 2010 Mar 18;362(11):986-93.
This research was funded in part by EGRP grants to Michael Thun, M.D., of the American Cancer Society; Susan Hankinson, Sc.D., of Brigham and Women’s Hospital, Harvard Medical School, and Harvard School; and David Hunter, M.D., Sc.D., of Harvard University School of Public Health.
Circadian Rhythm Gene Variants May Affect Breast Cancer Risk
Hoffman AE, Yi CH, Zheng T, Stevens RG, Leaderer D, Zhang Y, Holford TR, Hansen J, Paulson J, Zhu Y. CLOCK in breast tumorigenesis: Cancer Res2010 Feb 15;70(4):1459-68.
This research was funded by EGRP grants to Yong Zhu, Ph.D., of Yale University School.
Neural Network Model Effectively Discriminates Between Malignant and Benign Breast Lesions
Ayer T, Alagoz O, Chhatwal J, Shavlik JW, Kahn CE, Jr., Burnside ES. Breast cancer risk estimation with artificial neural networks revisited: discrimination and calibration. Cancer 2010 Jul 15;116(14):3310-21.
This research was funded in part by an EGRP grant to Oguzhan Alagoz, Ph.D., of the University of Wisconsin, Madison.
Young Girls Attaining Puberty at Earlier Ages; Investigators Examine Link to Environmental Exposures
Biro FM, Galvez MP, Greenspan LC, Succop PA, Vangeepuram N, Pinney SM, Teitelbaum S, Windham GC, Kushi LH, Wolff MS. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics 2010 Sep;126(3):e583-90.
This research was funded in part by EGRP grants to Robert Bornschein, Ph.D., of the University of Cincinnati; Jose Russo, M.D., of the Fox Chase Cancer Center; Sandra Haslam, Ph.D., of Michigan State University; and Robert Hiatt, M.D., Ph.D., of the University of California, San Francisco. Frank Biro, M.D., of the Cincinnati Children's Hospital Medical Center; Lawrence Kushi, Sc.D., of the Kaiser Foundation Research Institute; and Mary Wolff, Ph.D., of Mount Sinai School of Medicine, are EGRP grantees and the Principal Investigators for the ongoing Puberty Studies. The research funded by these grants is part of the Breast Cancer and the Environment Research Program (BCERP). Learn more about the BCERP.
Older, Early-Stage Breast Cancer Patients Have Better Survival With Lumpectomy Plus Radiation Rather Than Mastectomy
Keating NL, Landrum MB, Brooks JM, Chrischilles EA, Winer EP, Wright K, Volya R. Outcomes following local therapy for earlystage breast cancer in non-trial populations. Breast Cancer Res Treat 2011 Feb;125(3):803-13.
This research was funded by an EGRP grant to Nancy Keating, M.D., M.P.H., of Brigham and Women's Hospital and Harvard Medical School.
HIV Infection in Males Associated With HPV Infection
Smith JS, Moses S, Hudgens MG, Parker CB, Agot K, Maclean I, Ndinya-Achola JO, Snijders PJ, Meijer CJ, Bailey RC. Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection. J Infect Dis 2010 Jun 1;201(11):1677-85.
This research was funded in part by an EGRP grant to Jennifer Smith, Ph.D., of the University of North Carolina, Chapel Hill.
Genome-Wide Association Study Identifies New Susceptibility Locus for Follicular Lymphoma
Conde L, Halperin E, Akers NK, Brown KM, Smedby KE, Rothman N, Nieters A, Slager SL, Brooks-Wilson A, Agana L, Riby J, Liu J, Adami HO, Darabi H, Hjalgrim H, Low HQ, Humphreys K, Melbye M, Chang ET, Glimelius B, Cozen W, Davis S, Hartge P, Morton LM, Schenk M, Wang SS, Armstrong B, Kricker A, Milliken S, Purdue MP, Vajdic CM, Boyle P, Lan Q, Zahm SH, Zhang Y, Zheng T, Becker N, Benavente Y, Boffetta P, Brennan P, Butterbach K, Cocco P, Foretova L, Maynadié M, de Sanjosé S, Staines A, Spinelli JJ, Achenbach SJ, Call TG, Camp NJ, Glenn M, Caporaso NE, Cerhan JR, Cunningham JM, Goldin LR, Hanson CA, Kay NE, Lanasa MC, Leis JF, Marti GE, Rabe KG, Rassenti LZ, Spector LG, Strom SS, Vachon CM, Weinberg JB, Holly EA, Chanock S, Smith MT, Bracci PM, Skibola CF. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet 2010 Aug;42(8):661-4.
This research was funded in part by EGRP grants to Christine Skibola, Ph.D., of the University of California, Berkeley School of Public Health; Elizabeth Holly, Ph.D., M.P.H., and Paige Bracci, Ph.D., M.P.H. (not pictured), both of the University of California, San Francisco; Susan Slager, Ph.D., of the Mayo Clinic College of Medicine; and Tongzhang Zheng, D.Sc., of Yale University School of Public Health.
Elevated Anti-MUC1 Antibodies in Younger Women May Indicate Lower Ovarian Cancer Risk
Pinheiro SP, Hankinson SE, Tworoger SS, Rosner BA, McKolanis JR, Finn OJ, Cramer DW. Anti-MUC1 antibodies and ovarian cancer risk: prospective data from the Nurses' Health Studies. Cancer Epidemiol Biomarkers Prev 2010 Jun;19(6):1595-601.
This research was funded in part by EGRP grants to Susan Hankinson, Sc.D., of Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health; and Daniel Cramer, M.D., Sc.D., of Brigham and Women's Hospital and Harvard School of Public Health.
H. pylori Colonization in Non-O Blood Groups Associated With Pancreatic Cancer Risk
Risch HA, Yu H, Lu L, Kidd MS. ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study. J Natl Cancer Inst 2010 Apr 7;102(7):502-5.
This research was funded by an EGRP grant to Harvey Risch, M.D., Ph.D., of Yale University School of Medicine.
Macroenvironmental Factors and Genotype May Predict Poor Prostate Cancer Outcomes
Rebbeck TR, Weber AL, Walker AH, Stefflova K, Tran TV, Spangler E, Chang BL, Zeigler-Johnson CM. Context-dependent effects of genome-wide association study genotypes and macroenvironment on time to biochemical (prostate specific antigen) failure after prostatectomy. Cancer Epidemiol Biomarkers Prev 2010 Sep;19(9):2115-23.
This research was funded in part by an EGRP grant to Timothy Rebbeck, Ph.D., of the University of Pennsylvania.