Daniela Seminara, Ph.D., M.P.H.
Senior Scientist and Cohort and Consortia Coordination Team Lead

Photo of Daniela Seminara

Address:
National Institutes of Health
National Cancer Institute
Epidemiology and Genomics Research Program
Division of Cancer Control and Population Sciences
9609 Medical Center Drive, Rm. 4E130, MSC 9763
Bethesda, MD 20892
(For express delivery, use Rockville, MD 20850)

Interest Areas

  • Genomic epidemiology of cancer, including gene-gene and gene-environment interactions
  • Application of genomic epidemiology to public health, disease prevention, and therapy
  • Cross-disciplinary knowledge synthesis in cancer and other complex diseases
  • Familial cancer registries
  • Collaborative research through interdisciplinary cancer consortia, including data sharing policies

Degrees

  • Ph.D. - Molecular Biology
    University of Rome
  • M.P.H. - Epidemiology and Public Policy
    University of California, Berkeley

Biography

Dr. Seminara is a Senior Scientist and the Cohort and Consortia Coordination Team Lead for the Epidemiology and Genomics Research Program (EGRP). As EGRP's Scientific Consortia Coordinator, Dr. Seminara has designed, implemented and fostered a thriving network of more than 40 interdisciplinary and translational cancer epidemiology consortia with national and international reach. She designed and implemented the Breast and Colon Cancer Family Registries and made substantial contributions to the development of NCI and NIH policies related to genome-wide association studies (GWAS), such as data sharing. Dr. Seminara leads the Genetic Associations and Mechanisms in Oncology (GAME-ON): A Post-Genome Wide Association Initiative, a multi-million dollar initiative aimed at the translation of genomic data into preventive and therapeutic applications.

Dr. Seminara's recent membership in NCI and NIH committees include NCI's Biorepository Coordinating CommitteeExternal Web Site Policy, the NIH Genes, Environment, and Health Initiative (GEI) Genetics ProgramExternal Web Site Policy, the Board of Scientific Governors for the Center for Inherited Disease ResearchExternal Web Site Policy, the Human Variome ProjectExternal Web Site Policy, and the Public Health Genomics Interest Group (PHGIG).

Dr. Seminara has more than 20 years of experience in NIH's intramural and extramural programs and she initiated NCI's extramural genetic epidemiology program, for which she received an NIH Merit Award. Before coming to NIH, Dr. Seminara was Associate Professor and Associate Director for the Center for Inborn Metabolic Diseases in the Department of Pediatrics of the Catholic University Medical School in Rome.

Publications

Cheng I, Kocarnik JM, Dumitrescu L, Lindor NM, Chang-Claude J, Avery CL, Caberto CP, Love SA, Slattery ML, Chan AT, Baron JA, Hindorff LA, Park SL, Schumacher FR, Hoffmeister M, Kraft P, Butler AM, Duggan DJ, Hou L, Carlson CS, Monroe KR, Lin Y, Carty CL, Mann S, Ma J, Giovannucci EL, Fuchs CS, Newcomb PA, Jenkins MA, Hopper JL, Haile RW, Conti DV, Campbell PT, Potter JD, Caan BJ, Schoen RE, Hayes RB, Chanock SJ, Berndt SI, Küry S, Bézieau S, Ambite JL, Kumaraguruparan G, Richardson DM, Goodloe RJ, Dilks HH, Baker P, Zanke BW, Lemire M, Gallinger S, Hsu L, Jiao S, Harrison TA, Seminara D, Haiman CA, Kooperberg C, Wilkens LR, Hutter CM, White E, Crawford DC, Heiss G, Hudson TJ, Brenner H, Bush WS, Casey G, Le Marchand L, Peters U. Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.External Web Site Policy Gut. 2013 Aug 9. [Epub ahead of print]

Olson SH, Hsu M, Satagopan JM, Maisonneuve P, Silverman DT, Lucenteforte E, Anderson KE, Borgida A, Bracci PM, Bueno-de-Mesquita HB, Cotterchio M, Dai Q, Duell EJ, Fontham EH, Gallinger S, Holly EA, Ji BT, Kurtz RC, La Vecchia C, Lowenfels AB, Luckett B, Ludwig E, Petersen GM, Polesel J, Seminara D, Strayer L, Talamini R; the Pancreatic Cancer Case-Control Consortium. Allergies and Risk of Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Case-Control Consortium.External Web Site Policy Am J Epidemiol. 2013 Aug 14. [Epub ahead of print]

Khoury MJ, Lam TK, Ioannidis JP, Hartge P, Spitz MR, Buring JE, Chanock SJ, Croyle RT, Goddard KA, Ginsburg GS, Herceg Z, Hiatt RA, Hoover RN, Hunter DJ, Kramer BS, Lauer MS, Meyerhardt JA, Olopade OI, Palmer JR, Sellers TA, Seminara D, Ransohoff DF, Rebbeck TR, Tourassi G, Winn DM, Zauber A, Schully SD. Transforming epidemiology for 21st century medicine and public health.External Web Site Policy Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):508-16.

Jiao S, Hsu L, Berndt S, Bézieau S, Brenner H, Buchanan D, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock S, Conti DV, Curtis KR, Duggan D, Gallinger S, Gruber SB, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hutter CM, Jackson RD, Jenkins MA, Kantor ED, Kolonel LN, Küry S, Le Marchand L, Lemire M, Newcomb PA, Potter JD, Qu C, Rosse SA, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Ulrich CM, Zanke BW, Peters U. Genome-wide search for gene-gene interactions in colorectal cancer.External Web Site Policy PLoS One. 2012;7(12):e52535.

Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI, Bézieau S, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock SJ, Chen LS, Coetzee GA, Coetzee SG, Conti DV, Curtis KR, Duggan D, Edwards T, Fuchs CS, Gallinger S, Giovannucci EL, Gogarten SM, Gruber SB, Haile RW, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hunter DJ, Jackson RD, Jee SH, Jenkins MA, Jia WH, Kolonel LN, Kooperberg C, Küry S, Lacroix AZ, Laurie CC, Laurie CA, Le Marchand L, Lemire M, Levine D, Lindor NM, Liu Y, Ma J, Makar KW, Matsuo K, Newcomb PA, Potter JD, Prentice RL, Qu C, Rohan T, Rosse SA, Schoen RE, Seminara D, Shrubsole M, Shu XO, Slattery ML, Taverna D, Thibodeau SN, Ulrich CM, White E, Xiang Y, Zanke BW, Zeng YX, Zhang B, Zheng W, Hsu L; Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium. Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.External Web Site Policy Gastroenterology. 2013 Apr;144(4):799-807.e24.

Elena JW, Travis LB, Simonds NI, Ambrosone CB, Ballard-Barbash R, Bhatia S, Cerhan JR, Hartge P, Heist RS, Kushi LH, Lash TL, Morton LM, Onel K, Pierce JP, Robison LL, Rowland JH, Schrag D, Sellers TA, Seminara D, Shu XO, Thomas NE, Ulrich CM, Freedman AN. Leveraging epidemiology and clinical studies of cancer outcomes: recommendations and opportunities for translational research.External Web Site Policy J Natl Cancer Inst. 2013 Jan 16;105(2):85-94.

Xu J, Lange EM, Lu L, Zheng SL, Wang Z, Thibodeau SN, Cannon-Albright LA, Teerlink CC, Camp NJ, Johnson AM, Zuhlke KA, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Maier C, Luedeke M, Vogel W, Schleutker J, Wahlfors T, Tammela T, Schaid D, McDonnell SK, DeRycke MS, Cancel-Tassin G, Cussenot O, Wiklund F, Grönberg H, Eeles R, Easton D, Kote-Jarai Z, Whittemore AS, Hsieh CL, Giles GG, Hopper JL, Severi G, Catalona WJ, Mandal D, Ledet E, Foulkes WD, Hamel N, Mahle L, Moller P, Powell I, Bailey-Wilson JE, Carpten JD, Seminara D, Cooney KA, Isaacs WB; International Consortium for Prostate Cancer Genetics. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG).External Web Site Policy Hum Genet. 2013 Jan;132(1):5-14.

Gong J, Hutter C, Baron JA, Berndt S, Caan B, Campbell PT, Casey G, Chan AT, Cotterchio M, Fuchs CS, Gallinger S, Giovannucci E, Harrison T, Hayes R, Hsu L, Jiao S, Lin Y, Lindor NM, Newcomb P, Pflugeisen B, Phipps AI, Rohan T, Schoen R, Seminara D, Slattery ML, Stelling D, Thomas F, Warnick G, White E, Potter J, Peters U. A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factors.External Web Site Policy Cancer Epidemiol Biomarkers Prev. 2012 Nov;21(11):1974-85.

Duell EJ, Lucenteforte E, Olson SH, Bracci PM, Li D, Risch HA, Silverman DT, Ji BT, Gallinger S, Holly EA, Fontham EH, Maisonneuve P, Bueno-de-Mesquita HB, Ghadirian P, Kurtz RC, Ludwig E, Yu H, Lowenfels AB, Seminara D, Petersen GM, La Vecchia C, Boffetta P. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).External Web Site Policy Ann Oncol. 2012 Nov;23(11):2964-70.

Khoury MJ, Freedman AN, Gillanders EM, Harvey CE, Kaefer C, Reid BC, Rogers S, Schully SD, Seminara D, Verma M. Frontiers in cancer epidemiology: a challenge to the research community from the Epidemiology and Genomics Research Program at the National Cancer Institute.External Web Site Policy Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):999-1001.

Boffetta P, Winn DM, Ioannidis JP, Thomas DC, Little J, Smith GD, Cogliano VJ, Hecht SS, Seminara D, Vineis P, Khoury MJ. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans.External Web Site Policy Int J Epidemiol. 2012 Jun;41(3):686-704.

Galanter JM, Fernandez-Lopez JC, Gignoux CR, Barnholtz-Sloan J, Fernandez-Rozadilla C, Via M, Hidalgo-Miranda A, Contreras AV, Figueroa LU, Raska P, Jimenez-Sanchez G, Zolezzi IS, Torres M, Ponte CR, Ruiz Y, Salas A, Nguyen E, Eng C, Borjas L, Zabala W, Barreto G, González FR, Ibarra A, Taboada P, Porras L, Moreno F, Bigham A, Gutierrez G, Brutsaert T, León-Velarde F, Moore LG, Vargas E, Cruz M, Escobedo J, Rodriguez-Santana J, Rodriguez-Cintrón W, Chapela R, Ford JG, Bustamante C, Seminara D, Shriver M, Ziv E, Burchard EG, Haile R, Parra E, Carracedo A; LACE Consortium. Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas.External Web Site Policy PLoS Genet. 2012;8(3):e1002554.

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