Joint China-U.S. Workshop on Environmental Pollution and Cancer


Overview

NCI's Epidemiology and Genetics Research Program (EGRP) led a U.S. team in developing the scientific agenda for a workshop with China on environmental pollution and cancer that was hosted by the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences (CAS) in Guangzhou, China, on January 5-8, 2010. The workshop was cosponsored with NIH's Fogarty International Center (FIC), National Institute of Environmental Health Sciences (NIEHS), and National Institute of Child Health and Human Development (NICHD), and CAS.

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Purpose

NIH and CAS each support several existing activities in the area of cancer and environmental health, and desire to expand research in areas of mutual interest in order to reduce the cancer burden in their two countries.

The Workshop's objective was to identify top emerging areas for research cooperation between China and the United States on cancer and environmental health with a focus on the impact of environmental pollution on cancer in children and adults. Each plenary session included discussion of the state-of-the-science, knowledge gaps, methodological issues, critical research questions for future investigation, and opportunities for China-U.S cooperation.

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Agenda

View Agenda for January 5, 2010
Tuesday, January 5 Topic
8:00 a.m. - 9:00 a.m. Registration
9:00 a.m. - 10:00 a.m. Welcoming Remarks

Donghai Wu
Director General Assistant
Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences

Jinghua Cao
Professor
Deputy Director General
Bureau of International Cooperation
Chinese Academy of Sciences

Ronghui Su
Deputy Director General
Bureau of Life Sciences and Biotechnology
Chinese Academy of Sciences

Robert T. Croyle
Director
Division of Cancer Control and Population Sciences
National Cancer Institute
National Institutes of Health

10:00 a.m. - 11:00 a.m. U.S. Keynote Address: Challenges and Opportunities in Investigating Cancer and the Environment

Jonathan Samet
University of Southern California

11:00 a.m. - 12:00 p.m. Chinese Keynote Address: The Current Status and Strategy in the Management of Lung Cancer

Yan Sun
Cancer Institute & Hospital
Chinese Academy of Medical Sciences

12:00 p.m. - 1:30 p.m. Lunch Break
1:30 p.m. - 1:45 p.m. Charge to Workshop Participants

U.S. Moderator:
Gary Ellison
National Cancer Institute
National Institutes of Health

Chinese Moderator:
Guangbiao Zhou
Institute of Zoology
Chinese Academy of Sciences

Plenary Session I: Pollutants, Hazards, and Solutions
Chairs: Xinming Wang, Chinese Academy of Sciences and Gary L. Ellison, National Cancer Institute, National Institutes of Health
1:45 p.m. - 3:45 p.m. Indoor and Outdoor Exposure to Hazardous Air Pollutants in Urban Guangzhou

Xinming Wang
Chinese Academy of Sciences

Exposure of E-waste Dismantlers to PCBs, OCPs, and PBDEs in South China

Xinhui Bi
Chinese Academy of Sciences

Study on Lung Cancer Prevalence and Prevention Strategy in Xuanwei County of Yunnan Province

Yize Xiao
Yunnan Centers for Disease Control and Prevention

Source Apportionment as Input into Health Effects Studies

Philip K. Hopke
Center for Air Resources Engineering and Science
Clarkson University

Challenges in Environmental Epidemiology of Cancer: The Trucking Industry Particle Study as an Example

Francine Laden
Harvard University

Challenges of Measuring Air Pollution: Chemical and Physical Characterization of On-Road and Non-Road Diesel Emissions

David R. Cocker, III
University of California, Riverside

3:15 p.m. - 3:45 p.m. Discussion
3:45 p.m. - 4:00 p.m. Break
Plenary Session II: Tobacco - Carcinogenesis, Prevention, and Control
Chairs: Gonghuan Yang, Chinese Centre for Disease Control and Prevention and Deirdre Lawrence, National Cancer Institute, National Institutes of Health
4:00 p.m. - 5:00 p.m. Trend of Mortality of Lung Cancer and Consumption of Cigarettes in Chinese

Gonghuan Yang
Chinese Centre for Disease Control and Prevention

Analysis of microRNA Expression Profile in Human Lung Adenocarcinoma with Current and Never Smoke

Biliang Zhang
Chinese Academy of Sciences

Changing Patterns and Risks for Smoking Initiation Among Young Women in China

Thomas Novotny
San Diego State University

When Prevention Fails: Cross-Cultural Considerations From the U.S. and China for Shaping Healthy Decisions in the Heat of the Adolescent Brain

C. Anderson (Andy) Johnson
The Claremont Graduate University

5:00 p.m. - 5:30 p.m. Discussion
Special Topic: The Huai River Project
Introductions: William J. Martin, National Institute of Environmental Health Sciences, National Institutes of Health and Gonghuan Yang, Chinese Centre for Disease Control and Prevention
5:30 p.m. - 6:30 p.m. Winter Heating or Clean Air? The Unintended Health Consequences of China's Huai River Policy

Michael Greenstone
Massachusetts Institute of Technology

Huai River Integrated Program on Cancer Control and Prevention

Xin Sun
National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention

6:30 p.m. - 6:45 p.m. Discussion

View Agenda for January 6, 2010
Wednesday, January 6 Topic
Penary Session III: Environmental Exposures Related to the Etiology of Cancer in Populations
Chairs: Hongbing Shen, Nanjing Medical University and Britt Reid, National Cancer Institute, National Institutes of Health
8:30 a.m. - 10:00 a.m. Environmental factors and Lung Cancer in Gejiu Tin Mine, Xuanwei County, and Fuyuan County, Yunnan Province, China

Yi Cao
Kunming Institute of Zoology

Views on Risk Factors for Lung Cancer Among Chinese Population

Yutang Gao
Shanghai Cancer Institute

SNPs in 15q25 and Lung Cancer Susceptibility: Ethnic Differences

Hongbing Shen
Nanjing Medical University

Indoor Air Pollution, Environmental Tobacco Smoking, and Risk of Lung Cancer

Zuo-Feng Zhang
Center for Environmental Genomics
University of California, Los Angeles

Risk of Lung Cancer in a Cohort of Female Textile Workers in Shanghai

David B. Thomas
The Fred Hutchinson Cancer Research Center and University of Washington

A Prospective Cohort Study in Daqing City, People's Republic of China

Tongzhang Zheng
Yale University

10:00 a.m. - 10:30 a.m. Discussion
10:30 a.m. - 10:45 a.m. Break
Plenary Session IV: Environmental Exposures and Childhood Cancer
Chairs: Zhu Li, Peking University and Carol Kasten, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
10:45 a.m. - 11:30 a.m. Evaluation of Risk Factors for Childhood Cancer using the China Children and Family Cohort Study

Zhu Li
Peking University

Environmental Exposure and Risk of Childhood Cancers

Patricia A. Buffler
University of California, Berkeley

The U.S. National Children's Study - Environmental Influences on the Health and Development of 100,000 Children in the United States

Carol Kasten
The Eunice Kennedy Shriver National Institute of Child Health and Human Development

11:30 a.m. - 12:00 p.m. Discussion
12:00 p.m. - 1:30 p.m. Lunch
Plenary Session V: Lung Cancer Pathogenesis
Chairs: Hongbin Ji, Chinese Academy of Sciences and Peter Ujhazy, National Cancer Institute, National Institutes of Health
1:30 p.m. - 2:30 p.m. Modeling of Human Lung Cancers with EGFR Kinase Domain Mutations

Hongbin Ji
Chinese Academy of Sciences

Artemin Stimulates Progression of Human Non-Small Cell Lung Carcinoma

Tao Zhu
University of Science and Technology of China

NCI's Specialized Program of Research Excellence as a Model for Translational Cancer Research

Peter Ujhazy
National Cancer Institute

New Perspectives on the Influence of Genes and Environment to Lung Cancer and Smoking

Neil Caporaso
National Cancer Institute

2:30 p.m. - 2:50 p.m. Discussion
2:50 p.m. - 3:05 p.m. Break
Plenary Session VI: Pathogenesis and Therapeutics
Chairs: Zhihai Qin, Chinese Academy of Sciences and William J. Martin, National Institute of Environmental Health Sciences, National Institutes of Health
3:05 p.m. - 4:20 p.m. Targeting Stroma for Tumor Rejection

Zhihai Qin
Chinese Academy of Sciences

Monitoring Glycoproteins as a Guide to Prognosis in Chemotherapy

Zhili Li
Institute of Basic Medical Sciences
Chinese Academy of Medical Sciences and Peking Union Medical College

Cancerous Inhibitor of Phosphatase in Lung Cancer

Guangbiao Zhou
Institute of Zoology
Chinese Academy of Sciences

DNA Repair as Predictors of Treatment Response and Survival of Lung Cancer

Qingyi Wei
The University of Texas MD Anderson Cancer Center

Personalization of Cancer Therapy - Advancement and Challenges

Zhongxing Liao
University of Texas M.D. Anderson Cancer Center

4:20 p.m. - 4:45 p.m. Discussion

View Agenda for January 7, 2010
Thursday, January 7 Topic
National Institutes of Health (NIH) Funding Opportunities Panel Discussion
8:30 a.m. - 10:00 a.m. NIH Funding Opportunities for Collaborative Research

Joshua Rosenthal
Fogarty International Center

How the NIH Grants Process Works

Britt C. Reid
National Cancer Institute

Advice on Grantsmanship from Experienced Investigators

Tongzhang Zheng
Yale University

Qingyi Wei
The University of Texas M.D. Anderson Cancer Center

10:00 a.m.- 10:20 a.m. Break
Chinese Academy of Sciences (CAS) and National Natural Science Foundation of China (NSFC) Funding Opportunities
10:20 a.m. - 12:30 p.m. NSFC Funding

Huai Chen
Director, Bureau of International Cooperation
National Natural Science Foundation of China

CAS Funding Opportunities Panel Discussion

Jinghua Cao
Deputy Director General, Bureau of International Cooperation
Chinese Academy of Sciences

Xuliang Zhuang
Director, Division of Ecological and Environmental Sciences
Bureau of Science and Technology for Resources and Environment
Chinese Academy of Sciences

Yi Shen
Deputy Director, Division of Biomedical Sciences
Bureau of Life Sciences and Biotechnology
Chinese Academy of Sciences

12:30 p.m. - 2:00 p.m. Lunch
2:00 p.m. - 5:30 p.m. Site visit to several locations in Guangzhou to examine natural environmental exposure settings

View Agenda for January 8, 2010
Friday, January 8 Time
9:00 a.m. - 10:00 a.m. Closing Remarks

Linda Birnbaum
Director, National Institute of Environmental Health Sciences
National Institutes of Health

Donghai Wu
Director General Assistant, Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences

10:00 a.m. - 1:00 p.m. Small collaborative meetings for scientists at various local facilities, universities and laboratories in Guangzhou

Planning committee meeting to synthesize the main points, prepare meeting summary, and plan publication of the meeting report(s) (closed meeting)

1:00 p.m. - 2:00 p.m. Lunch
2:00 p.m. - 4:00 p.m. Planning Committee Meeting (closed meeting)

The workshop was featured in the NCI Cancer BulletinExternal Web Site Policy and the NIEHS Environmental FactorExternal Web Site Policy.

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Workshop Summary

Executive Summary Report Cover

View Executive Summary of the January 2010 Workshop [PDF - 325 KB]

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Contact

Gary L. Ellison, Ph.D., M.P.H., Program Director, Modifiable Risk Factors Branch, EGRP

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