Using Immune Marker Panels to Uncover the Role of Inflammation in Cancer


Overview

The 1.5-day "Using Immune Marker Panels to Uncover the Role of Inflammation in Cancer" workshop was sponsored by the Epidemiology and Genomics Research Program (EGRP) in NCI's Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Epidemiology and Genetics (DCEG). Representatives from institutions involved in studies of inflammation and cancer using technologies to assay inflammatory proteins were invited to share their experiences with new technologies and findings from association studies. At the end of the workshop, participants defined areas of consensus, and identified and summarized knowledge gaps.

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Agenda

The workshop sessions included discussion of disease associations, biological interpretation of findings, assay performance, and statistical considerations.

View agenda for Wednesday, June 4
June 4, 2014 Topic
8:15 a.m. Registration
8:30 a.m.

Welcome
Mukesh Verma, Ph.D.
EGRP, DCCPS, NCI

Allan Hildesheim, Ph.D.
DCEG, NCI

Session 1: Ongoing Studies With Inflammatory Marker Panel Assays and Disease Associations in Prospective Cohorts
Chairs: Anil Chaturvedi, Ph.D., DCEG, NCI and Meredith Shiels, Ph.D., M.H.S., DCEG, NCI
9:00 a.m. Introduction to the Session
Anil Chaturvedi, Ph.D.
DCEG, NCI
9:05 a.m. Studies Within NCI Cohorts—Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study
Mark Purdue, Ph.D.
DCEG, NCI
9:25 a.m. Cytokines Associated With Development of Cirrhosis and Hepatocellular Carcinoma in Patients With Chronic Hepatitis
Hwai-I Yang, Ph.D.
Academia Sinica
9:45 a.m. Studies in the California Birth Cohort
Joseph Wiemels, Ph.D.
University of California, San Francisco
10:05 a.m. Break
10:20 a.m. Studies in the Women's Health Initiative Cohort
Gloria Ho, Ph.D., M.P.H.
Albert Einstein College of Medicine
10:40 a.m. Studies in the International Agency for Research on Cancer (IARC) and European Studies
Mattias Johansson, Ph.D.
IARC
11:00 a.m. Studies in the Vanderbilt Cohorts
Wei Zheng, M.D., Ph.D.
Vanderbilt University
11:20 a.m. Studies on Epidemiologic Correlates of Inflammation Marker Levels
Dr. Shiels
DCEG, NCI
11:40 a.m. Panel Discussion
12:30 p.m. Lunch
Session 2: Biologic Interpretation of Marker Association Studies
Chair: Ron Germain, M.D., Ph.D., National Institute of Allergy and Infectious Diseases (NIAID)
1:00 p.m. Introduction to the Session
Ron Germain, M.D., Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
1:10 p.m. Immunologic Perspectives on Exposure/Disease Associations in Epidemiologic Studies - Soluble Receptors and Cytokines
Daniel McVicar, Ph.D.
Center for Cancer Research, NCI
1:30 p.m. Immunologic Perspectives on Exposure/Disease Associations in Epidemiologic Studies - Chemokines
Joshua Farber, M.D.
NIAID
1:50 p.m. Local Versus Systemic Markers of Inflammation
Ron Germain, M.D., Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
2:10 p.m. Panel Discussion
3:10 p.m. Break
Session 3: State of the Science on Multiplexed Inflammation Marker Platforms/Assays
Chair: Ligia Pinto, Ph.D., Leidos
3:30 p.m. Introduction to the Session
Ligia Pinto, Ph.D.
Leidos
3:40 p.m. An Overview of Approaches for Detection of Immune Markers in Serum and Plasma
Phil McCoy, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
4:00 p.m. Multiplexed Immunometric Assays for the Quantification of Biomarkers of Inflammation: Stability, Reproducibility, and Selection of Biomarkers
Otoniel Martinez-Maza, Ph.D.
University of California, Los Angeles
4:20 p.m. Standardization of Multiplex Assays and Evaluation of Performance
Jay Bream, Ph.D.
The Johns Hopkins University
4:40 p.m. Panel Discussion
5:30 p.m. Wrap Up
5:40 p.m. Adjournment

View agenda for Thursday, June 5
June 5, 2014 Topic
Session 4: Statistical issues in MIP Studies
Chair: Ruth Pfeiffer, Ph.D., DCEG, NCI
8:15 a.m. Introduction to the Session
Ruth Pfeiffer, Ph.D.
DCEG, NCI
8:20 a.m. Conceptual and Inferential Considerations in the Design and Analysis of Circulating Inflammatory Markers in Relation to Cancer Incidence and Outcomes
Elizabeth Platz, Sc.D.
The Johns Hopkins University
8:40 a.m. Assessing Assay Reproducibility and the Impact of Measurement Errors on Epidemiological Analyses
Hormuzd Katki, Ph.D.
DCEG, NCI
9:00 a.m. Dimensionality Reduction Methods for Multivariate Cytokines Data
Ravi Varadhan, Ph.D.
The Johns Hopkins University
9:20 a.m. Panel Discussion
10:00 a.m. Break
Session 5: Break-Out Groups and Wrap-Up Session
Chairs: Drs. Verma and Hildesheim
10:20 a.m. Break-Out Groups
3 break-out groups were formed to discuss what we have learned from this meeting about the state of the science, gaps, and research strategies for the future.
  1. Laboratory Methods
    Moderator: Dr. Pinto
  2. Epidemiological Studies and Statistical Considerations
    Moderator: Dr. Shiels
  3. Epidemiology-Immunology Interface
    Moderator: Dr. Hildesheim
Workshop Wrap-Up and Discussion of Future Needs
11:20 a.m. Laboratory Methods: Future Needs
Dr. Pinto, Rapporteur
11:35 a.m. Epidemiological Studies and Statistical Considerations: Future Needs
Dr. Shiels, Rapporteur
11:50 a.m. Epidemiology-Immunology Interface, Functional studies: Future needs
Dr. Hildesheim, Rapporteur
12:05 p.m. Conclusion and Recommendations
12:20 p.m. Adjournment

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Workshop Summary

A meeting summary currently is in development, and the citation and PubMed link will be included here when completed.

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Planning Committee

  • Danielle Carrick, Ph.D., M.H.S., Program Director, Host Susceptibility Factors Branch, EGRP, DCCPS, NCI
  • Anil Chaturvedi, Ph.D., Investigator, Infections and Immunoepidemiology Branch, DCEG, NCI
  • Rao Divi, Ph.D., Program Director, Methods and Technologies Branch, EGRP, DCCPS, NCI
  • Kelly Filipski, Ph.D., M.P.H., Program Director, Clinical and Translational Epidemiology Branch, EGRP, DCCPS, NCI
  • Elizabeth Hebert, Cancer Research Training Award Fellow, Methods and Technologies Branch, EGRP, DCCPS, NCI
  • Allan Hildesheim, Ph.D., Chief, Infections and Immunoepidemiology Branch, DCEG, NCI
  • Muin Khoury, M.D., Ph.D., Associate Director, EGRP, DCCPS, NCI
  • Meredith Shiels, Ph.D., M.H.S., Research Fellow, Infections and Immunoepidemiology Branch, DCEG, NCI
  • Joseph Su, Ph.D., M.P.H., Program Director, Modifiable Risk Factors Branch, EGRP, DCCPS, NCI
  • Mukesh Verma, Ph.D., Chief, Methods and Technologies Branch, EGRP, DCCPS, NCI

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Contacts

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