EGRP News Flash - March 6, 2008

Administrative Supplements for Gene Identification Efforts: Replication and Fine-Mapping Studies: The Genes, Environment, and Health Initiative (GEI)

On behalf of the NIH-wide Genes, Environment, and Health Initiative (GEI), NCI's Epidemiology and Genetics Research Program (EGRP) announces the availability of administrative supplements for NIH-funded genetic association studies aimed at identifying genetic factors involved in complex trait etiology. The purpose of this funding opportunity is to provide support for replication studies (with or without fine-mapping) of genetic regions putatively associated with the studied complex trait(s) (primarily those identified by genome-wide association studies (GWAS)) in order to maximize the productivity of NIH-funded GWAS. This opportunity is open to all current NIH awardees of R01, P01, and P50 grants, and U01, U19, and U54 cooperative agreements, provided specific conditions are met. Learn more about the GEI initiative.

Priority funding will be given to studies with one of more of the following characteristics: synergy with NIH's Gene Environment Association Studies, breadth of available phenotypic and exposure measures for study participants and plans for sharing data with the research community. Studies should focus on replication in the original discovery population if little replication information is available to date. If the original "hit" has been sufficiently replicated, studies should focus on populations not included in the initial GWAS or subsequent replication studies, such as groups with different environmental exposures.

Requests are due by May 1, 2008. Budget requests must not exceed $400,000 in total costs for funding not to exceed 12 months. Please note that the NIH Center for Scientific Review (CSR) is not involved in receipt and processing of these requests. NCI's EGRP will receive these administrative supplement requests.

Contact: Elizabeth Gillanders, Ph.D., Program Director, Host Susceptibility Factors Branch.

Access the NIH Guide for Grants and Contracts for details: NOT-CA-08-011External Web Site Policy: Administrative Supplements for Gene Identification Efforts: Replication and Fine-Mapping Studies for the Genes, Environment, and Health Initiative (GEI)

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