EGRP News Flash - October 15, 2008

Funding Opportunity Announcement: Replication and Fine-mapping Studies for the Genes, Environment and Health Initiative (R01)

On behalf of the National Institutes of Health (NIH)-wide Genes, Environment and Health Initiative (GEI), the National Cancer Institute's (NCI) Epidemiology and Genetics Research Program (EGRP) announces a Funding Opportunity Announcement (FOA) to provide support for replication and fine-mapping studies of genetic regions that are putatively associated with common complex traits, such as those identified by genome-wide association studies (GWAS). The FOA solicits applications for projects aimed to enhance the identification of causal variants influencing complex diseases. Since it is an NIH-wide initiative, any phenotype may be appropriate for these projects (i.e., studies need not be oriented on cancer or cancer-related phenotypes). The emphasis is on follow-up studies that are needed to replicate and validate initial GWAS findings to: (a) eliminate false positive associations; (b) narrow the association intervals of interest; and (c) to extend the findings to diverse populations (such as diversity in race, ethnicity, or environmental exposures) and related phenotypes. Only a replication study alone, or a replication study plus a fine-mapping effort, may be proposed.

This FOA will not support recruitment of human subjects, collection of human specimens, collection of medical or phenotype data, studies using animal models, or discovery genome-wide association efforts. Investigators are expected to have access to phenotypic and exposure data, and DNA sources, from an existing study population(s) of sufficient size at the time of application, in order to adequately address the specific aims. Well-designed replication studies should follow the NCI-NHGRI Working Group on Replication in Association Studies' guidelines for what constitutes replication of a genotype-phenotype association and how it can best be achieved.

Using the NIH Research Project Grant (R01) funding mechanism, this FOA focuses on discrete, specified, circumscribed projects based upon strong preliminary data. Unlike typical multi-year R01 projects, however, this FOA solicits applications solely for projects that can be completed in one funding period not exceeding 12 months.

This FOA is administered by the National Cancer Institute (NCI) but it has been developed as part of the NIH-wide GEI.

October 24, 2008 is the opening date for this announcement as well as the Letter of Intent Receipt Date. Applications are due by December 1, 2008.

The contact for inquiries is EGRP's Elizabeth Gillanders, Ph.D., Program Director, Host Susceptibility Factors Branch.

  • Access the NIH Guide for Grants and Contracts for details: RFA-CA-09-003External Web Site Policy (R01)

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