EGRP News Flash - April 5, 2011

Funding Opportunity Announcement Reissued for Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts – With Important Changes

The National Cancer Institute’s (NCI) Division of Cancer Control and Population Sciences (DCCPS) reissued its Funding Opportunity Announcement (FOA) in the NIH Guide for Grants and Contracts inviting applications for targeted infrastructure support for core functions of cancer epidemiology cohorts (CECs) and methodological research. This FOA will be supported through a new NIH grant mechanism, the UM1 Multi-Component Research Project Cooperative Agreement, and a new Program Announcement with Special Review (PAR) number.

The former PAR (PAR 10-283) “morphed” into the new PAR-11-167. Because of a change at NIH, specifically a new convention for naming certain types of grant FOA mechanisms, the former PAR was discontinued and replaced with this new one.

Support is envisioned for two types of CECs:

  1. A cohort of at least 10,000 study participants that is intended to examine multiple exposures and study participant characteristics on the risk of one or multiple types of incident cancer, or
  2. A cohort of at least the same size designed to study cancer-related outcomes among persons diagnosed with cancer. Outcomes among cancer survivors include, but are not limited to, cancer recurrence, development of new primaries, survival and physical health conditions, chronic diseases related to the cancer, cancer-directed therapy, or its consequences.

This FOA must be used for all requests for support to continue existing CECs or establish new CECs.

Cohorts established to assess the role of exposures in the workplace on risk of cancer (i.e., “occupational cohorts”) may be appropriate for this FOA, but only if they were established to examine a broad range of exposures potentially experienced by the general public and/or genomic factors affecting cancer risk outcomes after cancer diagnosis. Cohorts focusing primarily on cancer risks associated with exposures in the workplace are not appropriate.

This FOA is intended to support cohorts established to identify factors that increase or decrease the risk of developing cancer or the incidence of health outcomes after cancer. Therefore, cancer surveillance activities and development and maintenance of registries of persons with particular characteristics that do not address identification of factors increasing or decreasing risk are not appropriate.

The activities supported by this FOA include the establishment, maintenance, or upgrade of CEC core functions, such as recruitment, retention, and biospecimen collection. Methodological research to validate or evaluate new or existing approaches to core infrastructure functions is also appropriate.

Research projects relying on CEC infrastructure are NOT appropriate for this FOA and such projects are expected to seek support through the appropriate grant mechanism, such as the investigator-initiated Research Project (R01) and Program Project (P01).

Letter of Intent due dates for 2011 are June 6 and October 10. Application receipt dates for 2011 are July 6 and November 10. The PAR expires November 9, 2013.

A set of Frequently Asked Questions is available. The contact for general questions is Deborah M. Winn, Ph.D., Deputy Director, Division of Cancer Control and Population Sciences; e-mail:

  • Access the NIH Guide for Grants and Contracts for details: PAR-11-167External Web Site Policy

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