Metabolomics Quality Assurance & Quality Control Consortium (mQACC)


Overview

The metabolomics Quality Assurance and quality Control Consortium (mQACC) was established in February 2018 with the goal to develop a collaborative effort among relevant stakeholders in academic, industry and government institutions to address key quality assurance (QA) and quality control (QC) issues in the untargeted metabolomics field. The consortium formed as a result of the Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomics Studies, a meeting held at the National Cancer Institute in October 2017.

The consortium currently includes representatives from the United States, Europe and Asia, including instrument manufacturers, commercial metabolomics laboratories, and government and academic stakeholders.

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Objectives

The consortium’s mission is to engage the metabolomics community to communicate and promote the development, dissemination and harmonization of best QA/QC practices in untargeted metabolomics through the following objectives:

  • To identify, catalog, harmonize and disseminate QA/QC best practices for untargeted metabolomics.
  • To establish mechanisms to enable the metabolomics community to adopt QA/QC best practices.
  • To promote and support systematic training in QA/QC best practices for the metabolomics community.
  • To encourage the prioritization and development of reference materials applicable to metabolomics research.

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Working Groups


Reference and Test Material Working Group

Chair: Katrice A. Lippa, National Institute of Standards and Technology

Membership:
  • Warwick B. Dunn, University of Birmingham
  • Roberto Flores, National Cancer Institute
  • Thomas Hartung, Johns Hopkins School of Public Health
  • Majda Haznadar, Food and Drug Administration
  • Christina M. Jones, National Institute of Standards and Technology
  • Matthew R. Lewis, Imperial College London
  • Katrice A. Lippa (Chair), National Institute of Standards and Technology
  • Ioanna Ntai, Thermo Fisher Scientific
  • Daniel Raftery, University of Washington
  • Tracey Schock, National Institutes of Standards and Technology
  • Amanda Souza, Thermo Fisher Scientific
  • Fariba Tayyari, University of Georgia
  • Georgios Theodoridis, Aristotle University
  • Baljit Ubhi, AB Sciex
  • Vidya Velagapudi, University of Helsinki
  • Ian Wilson, Imperial College London
  • Krista Zanetti, National Cancer Institute

Ongoing activities:
The metabolomics community urgently needs reference and test materials that can be used for measurements across laboratories and data standardization from different instrumental platforms to ensure translation of biological discoveries. Accordingly, we are actively working to develop measurement designs and prototype materials that can be utilized across most, if not all, instrumentation platforms and employed for interlaboratory comparisons. Additionally, we are defining the measurement challenges that different types of reference and test materials have the potential to address, as well as establishing best use practices for test and reference materials.

Anticipated deliverables:

  • A survey will be disseminated to more clearly define the test and reference material needs of the broader metabolomics community.
  • A manuscript will follow that details the initial charge of the working group, and its current approach to enable the development of community-accessible reference and test materials for metabolomics.


Dissemination of Current QA/QC Practices Working Group

Chair: Anne M. Evans, Metabolon and Claire O’Donovan, European Bioinformatics Institute

Membership:
  • Richard D. Beger, Food and Drug Administration
  • Clary Clish, Broad Institute
  • Warwick B. Dunn, University of Birmingham
  • Anne M. Evans, Metabolon (Chair)
  • Rick Higashi, University of Kentucky
  • Ping-Ching Hsu, University of Arkansas for Medical Sciences
  • Maureen Kachman, University of Michigan
  • Jonathan Mosley, Environmental Protection Agency
  • Claire O’Donovan, European Bioinformatics Institute (Chair)
  • Rui Pinto, Imperial College London
  • Mary Playdon, Huntsman Cancer Institute
  • Sharon Ross, National Cancer Institute
  • Michael Schmidt, Advanced Pattern Analysis & Countermeasures Group
  • Fariba Tayyari, University of Georgia
  • Vidya Velagapudi, University of Helsinki

Ongoing activities:
Recently, a group of representatives from government, academic and commercial organizations with interest and involvement in metabolomics convened to discuss quality assurance (QA) and quality control (QC) in untargeted metabolomics. A repeated theme of this meeting was the need to educate the research community about the importance of QA and QC in untargeted metabolomics and the desire to develop a set of good practice standards and examples of QA/QC workflow that can be adopted by the community as a whole. Resulting from the meeting, mQACC was formed. One of the first objectives of the consortium is to describe the QA and QC protocols that have been established within consortium participants’ laboratories, and to share these practices with the broader metabolomics community as a platform for future QA/QC workflow development. These QA/QC protocols will be summarized and disseminated through publications and conference presentations.

Anticipated deliverables:
Short term deliverables include a manuscript containing the QA/QC practices of laboratories contributing content.

Additional publications which expand upon specific use cases or include a wider variety of contributors are possible.


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Membership


Apply for Membership

Eligibility Requirements

mQACC members should have an interest in the quality assurance and quality control for untargeted metabolomics and be affiliated with/represent industry (including scientific instrument companies, pharma and biotech as examples), government or academic institutions or contract research organizations.

Members should have or have held a position within the last five years at the postdoctoral level or higher. Students are not eligible for membership.

To maintain mQACC membership, active participation in at least one working group and attendance for at least three teleconference and/or face-to-face meetings every year is necessary.

Membership Types

There are two categories of membership for mQACC:

  • Affiliate Member: Member with practical experience in untargeted metabolomics, including quality assurance and quality control practices.
  • Non-affiliate Member: Member who does not have practical experience in the field of metabolomics, but in a related field (e.g. proteomics). A non-affiliate member must have an interest in the field, including an interest in quality assurance and quality control.

Application Process

Potential members are asked to submit the following two items via email to Dr. Krista Zanetti (zanettik@mail.nih.gov):

  • An application form [PDF - 941 KB]. The application form asks for the name of a current mQACC member (see list below on this page) who is willing to sponsor the application. Potential members who do not have access to a current mQACC member, but are otherwise qualified for membership should contact Dr. Krista Zanetti prior to submitting application materials to request a sponsor.
  • A current Curriculum Vitae and/or NIH Biosketch.

Membership is effective upon notification to and confirmation of acceptance by the Coordinating Committee.


Current Member List

Member Name Institution/Company
Fadi Abdi Biocrates, Inc.
Abbas Bandukwala Food and Drug Administration
Aiko Barsch Bruker Daltonics
Dan Bearden Consultant, Ichthus Unlimited, LLC
Rick Beger Food and Drug Administration
Bianca Bethan Metanomics Health
David Broadhurst Edith Cowan University
Clary Clish Broad Institute
Surendara Dasari Mayo Clinic
Leslie Derr National Institutes of Health
Warwick Dunn University of Birmingham
Annie Evans Metabolon Inc.
Steve Fischer Agilent Technologies
Roberto Flores National Cancer Institute
Thomas Flynn Food and Drug Administration (retired)
Thomas Hartung John Hopkins Bloomberg School of Public Health
Majda Haznadar Food and Drug Administration
David Herrington Wake Forest Health
Rick Higashi University of Kentucky
Ping-Ching Hsu University of Arkansas for Medical Sciences
Christina Jones National Institute of Standards and Technology
Maureen Kachman University of Michigan
Andre Kleensang John Hopkins Bloomberg School of Public Health
Matthew Lewis Imperial College London
Katrice Lippa National Institute of Standards and Technology
Padma Maruvada NIDDK
Sven Meyer Bruker Daltonics
Jonathan Mosley Environmental Protection Agency
Ioanna Ntai Thermo Fisher Scientific
Claire O'Donovan European Bioinformatics Institute
George Papanicolaou NHLBI
Rui Pinto Imperial College London
Mary Playdon Huntsman Cancer Center
Dan Raftery University of Washington
Sharon Ross National Cancer Institute
Michael Schmidt Advanced Pattern Analysis & Countermeasures Group
Tracey Schock National Institutes of Standards and Technology
Amanda Souza Thermo Fisher Scientific
Jinchun Sun Food and Drug Administration
Fariba Tayyari University of Georgia
Georgios Theodoridis Aristotle University
Baljit Ubhi AB Sciex
Mukesh Verma National Cancer Institute
Vidya Velagapudi University of Helsinki
Mark Viant University of Birmingham
Li-Rong Yu Food and Drug Administration
Tilmann Walk Metanomics
Ian Wilson Imperial College London
Krista Zanetti National Cancer Institute

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Publications

Berger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB, Dasari S, Derr L, Evans A, Fischer S, Flynn T, Hartung T, Herrington D, Higashi R, Hsu P-C, Jones C, Kachman M, Karuso H, Kruppa G, Lippa K, Maruvada P, Mosley J, Ntai I, O'Donovan C, Playdon M, Raftery D, Shaughnessy D, Souza A, Spaeder T, Salholz B, Tayyari F, Ubhi B, Verma M, Walk T, Wilson I, Witkin K, Bearden DW, Zanetti KA. Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics. 2019 Jan [Epub ahead of print]

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Initial Meeting, Workshops, and Conference Presentations

Initial Meeting

Workshops

Conferences

Oral Presentations

Poster Presentations

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Contact

For questions about mQACC or to inquire about becoming a member, contact Krista Zanetti, Ph.D., M.P.H., R.D.

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