Singapore Chinese Health Study

Lead Contact and/or Principal Investigator (PI):

  • Woon-Puay Koh, Ph.D., M.B.B.S.
    Duke-NUS Medical School
  • Jian-Min Yuan, M.D., M.P.H., Ph.D.
    University of Pittsburgh Cancer Institute

Years Funded: 1993
Funding Source: NCI Extramural Program (Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences; CA144034)
Year(s) of Enrollment: 1993-1998

The current research project continues support for a residential cohort of 63,257 middle-aged and older (45 to 74 years of age) Singapore Chinese men and women accrued between 1993 and 1998. At recruitment, each study participant was interviewed in person by a trained interviewer using a structured questionnaire that emphasized current diet assessed via a validated, 165-item food frequency questionnaire.

By April 2005, all surviving cohort participants had been recontacted for biospecimen donation. Samples were obtained from 32,543 subjects (28,330 bloods, 4,400 buccal cells, 31,895 urines), representing a consent rate of approximately 60 percent. The cohort has been followed for death, cancer occurrence, and other major health outcome occurrences through regular record linkage with the population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths, and through telephone follow-up interviews. The observed numbers of incident cancers and deaths within the cohort are comparable to corresponding expected numbers based on age- and sex-specific incidence rates for all Chinese in Singapore.

This prospective cohort study has contributed a wealth of knowledge on the role of dietary and other environmental factors in the etiology of cancer. More than 60 peer-reviewed articles have emanated from this study. Significant scientific contributions include finding:

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