Cohort of Swedish Men

Lead Contact and/or Principal Investigator (PI):

  • Alicja Wolk, Dr.Med.Sci.
    Karolinska Institutet, Sweden

Funded Since: 1997
Funding Source: Karolinska Institute, The Swedish Research Council (Vetenskapsrådet); The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (Formas); The Swedish Council for Working Life and Social Research (FAS); and the Swedish Cancer Society
Year(s) of Enrollment: 1997

The Cohort of Swedish Men (COSM) was established in 1997 when all men born between 1918 and 1952 and residing in Västmanland and Örebro counties in central Sweden received a questionnaire concerning diet and other lifestyle factors. Of the 100,303 eligible men, 48,850 (49%) responded to the questionnaire, which included items about diet, physical activity, medical history, and lifestyle factors such as cigarette smoking history and use of dietary supplements.

During 2008 and 2009, the exposure information was updated and extended by sending out two new questionnaires. Additionally in 2008, participants received a questionnaire on health, including several questions on signs or symptoms of disease, sleep, and social relations. In 2009, participants received a questionnaire on diet, dietary supplement use, and lifestyle factors. The majority of questions in the surveys have been validated.

Incident cases of cancer are ascertained by record linkages of the study population with the National Swedish Cancer Register and the Regional Cancer Registers. Cardiovascular and other diseases, as well as surgeries and causes of death, are identified by linkage to the National Inpatient Register and other registries at the Swedish Board of Health and Welfare. Ascertainment of cancer cases and other diseases is almost 100 percent complete. Dates of deaths are ascertained through the Swedish Death Register (100% complete), and information on dates that participants moved out of the study area is obtained by linkage with the Swedish Population Register.

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