Women's Lifestyle and Health (WLHS)

Lead Contact and/or Principal Investigator (PI):

Years Funded: 1991
Funding Source: Swedish Cancer Society
Year(s) of Enrollment: 1991-1992, 2003-2004
Study Website: http://ki.se/meb/wlhExternal Web Site Policy

Oral contraceptives, use of hormone replacement therapy, dietary habits, and other lifestyle factors affect the risk for cancer, cardiovascular diseases, and other chronic diseases in young women. Starting in 1991, a comprehensive questionnaire was mailed to 96,000 Swedish women aged 30 to 49 years. Approximately 50,000 completed questionnaires were returned providing detailed information on a wide range of lifestyle factors with a focus on oral contraceptive use, diet, UV light exposure, reproductive factors, and familial occurrence of cancer. This study is strictly coordinated with a similar study among 60,000 young women in Norway; apart from the dietary component, the questionnaires are identical and joint analyses are planned. In 2003 a second questionnaire was sent to all women to update information on lifestyle changes as well as to access psychiatric morbidity. Currently analysis is ongoing for several lifestyle factors and cancers of the breast, ovarium, endometrial, colorectal, skin, skin melanoma, lymphomas, as well as cardiovascular outcomes (myocardial infarction, haemorragic and ischaemic stroke), psychiatric diseases, sleeping disorders, and overall mortality.

Several analyses are being performed during the last years on different exposures, such as oral contraceptives, body mass index (BMI), changes in body size and shape, UV radiation exposure, alcohol consumption, smoking, and risk of different cancer sites and overall mortality. The data management and analysis of the follow-up questionnaire are being performed during the last years too.

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