COnsortium of METabolomics Studies (COMETS)

Mission and Objectives

The COnsortium of METabolomics Studies (COMETS) is an extramural-intramural partnership that promotes collaboration among prospective cohort studies that follow participants for a range of outcomes and perform metabolomic profiling of individuals. The objectives of COMETS are to:

  • Provide a framework to foster international collaborations among studies sharing common objectives;
  • Provide a forum for the discussion, development and pursuit of new collaborative studies and research directions;
  • Support the development of early career researchers; and
  • Advance the knowledge of the metabolome to improve our understanding of prediction of disease etiology, diagnosis and prognosis.

Based on these objectives, the aim of COMETS is to facilitate an open exchange of ideas, knowledge, and results in order to accelerate the study of metabolomics profiles associated with chronic disease phenotypes (e.g. heart disease, diabetes, cancer).

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Membership Eligibility for Studies

Cohorts must meet the following criteria:

  • Prospective cohort, 100+ participants with blood metabolomics data
  • Identified metabolite data
  • Follow-up for disease, including cancer and non-cancer outcomes
  • Mass-spectrometry platform, preferred; however, NMR data are eligible

Membership Categories for Investigators

Prospective members may apply to one of three membership categories within COMETS that can be applied for:

  • Steering Committee: Steering Committee members represent prospective cohort studies that have measured metabolomic profiles on their participants. At present, Steering Committee membership requires the represented study to have measured metabolomic profiles in blood using either mass-spectrometry or nuclear magnetic resonance (see membership eligibility above). However, as the technology advances and the COMETS consortium matures, this stipulation is open to modification. Steering Committee membership entitles individuals to vote, as well as to participate in Working Groups and become Working Group chairs. Membership is effective upon notification to and confirmation of acceptance by the current Steering Committee.

  • Consortium Member: Consortium members represent methodologic experts and/or investigators who are working in the field of metabolomics using metabolomic profiles measured in prospective cohort study participants. They are eligible to propose investigations to the Steering Committee for approval. Members are further required to maintain active participation in at least one working group and may become working group chairs. Membership is effective upon notification to and confirmation of acceptance by the Steering Committee. All Steering Committee members are Consortium Members, but not all Consortium Members are members of the Steering Committee. Consortium Membership alone does not provide voting rights for the Steering Committee.

  • Affiliate Member: Affiliate members can be either predoctoral or postdoctoral fellows or trainees who are part of a team led by either a Steering Committee or Consortium Member. They may lead or co-lead a project sponsored by a Steering Committee or Consortium Member and are eligible to transition to Member status upon transition to an independent research position. Affiliate members have no voting rights or eligibility for the Steering Committee.

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Proposing New COMETS Projects and Collaborations

Investigators interested in proposing a project should fill out the form below and e-mail the completed form to Krista Zanetti, Ph.D., M.P.H., R.D.

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COMETS Inaugural Meeting

COMETS was established at a meeting that took place at the NCI on October 28-29, 2014, "Think Tank on Metabolomics and Prospective Cohorts: How to Leverage Resources."

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For questions about COMETS or to inquire about becoming a member, contact Krista Zanetti, Ph.D., M.P.H., R.D.

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