Current COMETS Projects and Collaborations



Projects as of December 2021

Focus* Project Lead Investigator(s) Date Approved Status
Health Outcomes Blood metabolomic profiling in prostate cancer risk Demetrius Albanes Fall 2017 Ongoing
Health Outcomes Blood metabolites profiling in malignant glioma risk Demetrius Albanes Fall 2017 Ongoing
Metabolite(s)-Focused Levels of trimethylamine metabolites and their associations with dietary and non-dietary factors

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Project publications

Danxia Yu Fall 2017 Ongoing
Exposures and Genetics Genetic influences on the human metabolome Bing Yu Fall 2017 Ongoing
Exposures and Genetics The metabolome of overweight and obesity Rachel Kelly Fall 2017 Ongoing
Health Outcomes

Metabolomics of blood pressure regulation

Christina Menni Fall 2017 Ongoing
Health Outcomes Metabolomic profiles of dietary factors implicated in cancer etiology

Mary Playdon and Steven Moore

Spring 2018 Ongoing
Exposures and Genetics Genetics, metabolomics and cardiovascular disease risk Bing Yu and Cristina Menni Spring 2018 Ongoing
Health Outcomes Metabolomic profile of type 2 diabetes: the COnsortium of METabolomics Studies (COMETS) Nicholette Allred and Meghana Gadgil Spring 2018 Ongoing
Exposures and Genetics Genetic analysis and causal inference for untargeted signals from MS-based metabolite profiles

Joel Hirschhorn

Spring 2018 Ongoing
Metabolite(s)-Focused Genes, environment, and metabolic disease - convergence on ceramides Scott Summers and Mary Playdon Spring 2018 Ongoing
Health Outcomes Metabolomic profiles and pancreatic cancer risk Rachael Z. Stolzenberg-Solomon Spring 2018 Ongoing
Health Outcomes Metabolomic profiles of inflammatory & insulinemic dietary patterns and colorectal cancer risk Fred Tabung Winter 2019 Ongoing
Health Outcomes Blood metabolomics and lung cancer risk Wei Jie Seow Winter 2019 Ongoing
Health Outcomes Metabolomics of symptomatic gallstone disease in COMETS Amit Joshi Spring 2019 Ongoing
Exposures and Genetics Blood metabolites and their association with age: A COMETS study Steve Moore Spring 2019 Ongoing
Metabolite(s)-Focused Metabolomic profiles of circulating micronutrients and vitamin/nutritional supplements Demetrius Albanes Summer 2019 Ongoing
Methods Genetic imputation of metabolomics data Burcu Darst Summer 2019 Ongoing
Exposures and genetics Biomarkers of exposure and response to coffee Intake Marc Gunter Summer 2019 Ongoing
Health Outcomes Metabolic health and obesity-relevant diseases Mary Playdon Summer 2019 Ongoing
Health Outcomes Genetic metabolite scores for prediction of incident and prevalent cardiometabolic and pulmonary disease Nasa Sinnott-Armstrong Summer 2019 Ongoing
Health Outcomes Sex differences in the metabolome Raji Balasubramanian Winter 2020 Ongoing
Exposures and genetics A metabolomic characterization of APOE genotype using the COnsortium of METabolomics Studies Megan Marron Winter 2020 Ongoing
Health Outcomes Ceramides and cardiometabolic disease Scott Summers Spring 2020 Ongoing
Health Outcomes Metabolomic profiles of subclinical atherosclerosis Please add project Bing Yu Spring 2020 Ongoing
Health Outcomes Metabolomic profiles of colorectal cancer Jennifer Ose Summer 2020 Ongoing
Health Outcomes Prospective metabolomics study of gastric cancer Xiang Shu Summer 2020 Ongoing
Health Outcomes Consequences of air quality on cardiometabolic and pulmonary disease Nasa Sinnott-Armstrong Summer 2020 Ongoing
Health Outcomes Novel metabolomic pathways for hyperuricemia and gout Hyon K. Choi Winter 2021 Ongoing
Health Outcomes Metabolomics of inflammatory bowel disease and microscopic colitis Hamed Khalili and Amit Joshi Winter 2021 Ongoing
Health Outcomes Metabolomics of asthma, chronic obstructive pulmonary disease, lung function and allergy phenotypes: a COnsortium of METabolomics Studies (COMETS) analysis Jessica Lasky-Su, Rachel Kelly and Bo Chawes on behalf of the COMETS Lung IG Winter 2021 Ongoing
Health Outcomes Adulthood weight change, blood metabolomic profiles and lung function Hyung-Suk Yoon Winter 2021 Ongoing
Health Outcomes Magnesium-modifiable, microbial metabolites in association with diet, type 2 diabetes, and coronary heart disease Danxia Yu Winter 2021 Ongoing
Metabolite(s)-Focused Examination of vitamin D-associated and other metabolites in relation to cancer risk and mortality by race and ethnicity Wayne R. Lawrence and Gieira S. Jones Summer 2021 Ongoing
Metabolite(s)-Focused Dietary metabolomics in the COnsortium of METabolomics Studies Mary C. Playdon on behalf of the COMETS Diet IG Summer 2021 Ongoing
Health Outcomes Metabolome profile associated with interstitial lung abnormalities Scott Matson Winter 2022 Ongoing

* Projects are classified according to the following focus areas: (1) Health outcomes projects are focused on associations between metabolites and diseases/other health outcomes; (2) Exposures and genetics projects are focused on the interrelationships among exposures, or genetics and metabolites; (3) Metabolite(s)-focused projects will assess the interrelationships between exposures or genetics and specific metabolites (or classes of metabolites) and their role on health outcomes; (4) Methods projects will address analytical, platform, harmonization, statistical or other methodologic topics.