Trends in 21st Century Epidemiology: From Scientific Discoveries to Population Health Impact
December 12-13, 2012 - Bethesda, MD
- Agenda and Presentations
- Online Participation
- Workshop Recommendations
- Related Resources
More than a decade into the 21st century, we are at a major crossroads in our understanding of cancer. Tools of molecular biology, genomics, and other high throughput "omic" technologies are increasingly integrated into epidemiologic investigations. In a 2011 town hall meeting, Dr. Harold Varmus, NCI Director, said, "I expect to see a pretty dramatic revolution in epidemiology... defining cancers by genetic subsets. I expect to see molecular tools brought more forcefully into the realm of cancer diagnosis... talking about ways to discriminate among early lesions and pre-cancerous lesions that may have malignant potential."
Along with these emerging tools come refined social, behavioral, and environmental exposure measurements at the individual, community, and health system levels and the ability to assess gene-gene and gene-environment interactions. There is an increased focus on complex "systems" approaches in understanding the occurrence of cancer and intervening at multiple levels. All this has been influenced by tremendous advances in bioinformatics and information technology, allowing us to collect, analyze, and synthesize information from multiple disciplines at an ever increasing pace.
With these opportunities, however, come the major challenge of dealing with the data deluge and uncovering true causal relationships from the millions and millions of observations that are background noise. At the same time, increased consumer awareness and education has led to enhanced participation and co-ownership of research and research output. Thus, epidemiology now confronts important challenges and opportunities in the study of cancer and other diseases, and must make choices of direction, as it responds to rapid changes in the environment.
On December 12-13, 2012, NCI's Epidemiology and Genomics Research Program (EGRP) sponsored a workshop titled "Trends in 21st Century Epidemiology: From Scientific Discoveries to Population Health Impact" in Bethesda, MD. Researchers and thought leaders presented their perspectives on major facets of the epidemiologic enterprise.
Agenda and Presentations
During the workshop, a panel of experts with diverse perspectives offered brief assessments of the main challenges and most attractive opportunities for the five areas outlined below. Moderators led discussions among the panelists and workshop participants. Links to the presentations are included in the agenda (below) in the Topic column.
At the end of the meeting, workshop participants held an open discussion to help clarify and prioritize recommendations that will enhance the contribution of epidemiology in the next decade.View agenda for Wednesday, December 12 and links to presentations
|Wednesday, Dec. 12||Topic|
|12:00 p.m. - 1:00 p.m.||Registration|
|1:00 p.m. - 1:10 p.m.||
Robert T. Croyle, Ph.D.
|1:10 p.m. - 1:30 p.m.||
Charge to Participants [ PDF (1.45 MB), HTML ]
Muin J. Khoury, M.D., Ph.D.
Session 1: Setting the Stage: The Evolution of Epidemiology and its Applications to Cancer
Moderator: Robert T. Croyle, Ph.D., DCCPS, NCI
|1:30 p.m. - 2:00 p.m.||
Historical Perspectives on the Evolution of Cancer Epidemiology [ PDF (1.53 MB), HTML ]
Robert N. Hoover, M.D., Sc.D.
|2:00 p.m. - 3:00 p.m.||
Panel and Audience Discussion [ PDF (538 KB), HTML ]
Timothy Rebbeck, Ph.D.
Margaret R. Spitz, M.D.
|3:00 p.m. - 3:15 p.m.||Break|
Session 2: The Impact of New Methods and Technologies on Epidemiologic Research
Moderator: Stephen J. Chanock, M.D., DCEG, NCI
|3:15 p.m. - 3:45 p.m.||
Technology-Driven Epidemiology: A Paradigm Shift [ HTML ]
Geoffrey S. Ginsburg, M.D., Ph.D.
|3:45 p.m. - 5:00 p.m.||
Panel and Audience Discussion [ PDF (1 MB), HTML ]
Thomas A. Sellers, Ph.D., M.P.H.
Michael Snyder, Ph.D.
Georgia D. Tourassi, Ph.D.
|6:00 p.m. - 8:00 p.m.||Dinner at Local Restaurant
View agenda for Thursday, December 13 and links to presentations
|Thursday, Dec. 13||Topic|
|7:30 a.m. - 8:00 a.m.||Registration|
Session 3: The Evolution of Epidemiologic Cohorts in the Study of Natural History of Cancer and Other Diseases
Moderator: Deborah M. Winn, Ph.D., DCCPS, NCI
|8:00 a.m. - 8:30 a.m.||
What Have We Learned From Epidemiology Cohorts and Where Should We Be Going Next? [ PDF (407 KB), HTML ]
Julie Buring, Sc.D., M.S.
|8:30 a.m. - 9:30 a.m.||
Panel and Audience Discussion [ PDF (706 KB), HTML ]
Lyle Palmer, Ph.D.
Leslie L. Robison, Ph.D. (unable to attend)
Daniela Seminara, Ph.D., M.P.H.
Session 4: Use of Epidemiologic Research to Advance Clinical and Public Health Practice: Bridging the Evidence Gap with Observational Studies and Randomized Clinical Trials
Moderator: Sheri D. Schully, Ph.D., EGRP, DCCPS, NCI
|9:30 a.m. - 10:00 a.m.||
Epidemiology and Evidence-Based Cancer Prevention [ PDF (458 KB), HTML ]
David F. Ransohoff, M.D.
|10:00 a.m. - 11:00 a.m.||
Panel and Audience Discussion [ PDF (480 KB), HTML ]
Michael Lauer, M.D.
Jeffrey A. Meyerhardt, M.D., M.P.H.
Olufunmilayo I. Olopade, M.D. F.A.C.P.
|11:00 a.m. - 11:15 a.m.||Break|
Session 5: Use of Epidemiology in Knowledge Integration and Meta-Research
Moderator: Muin J. Khoury, M.D., Ph.D., EGRP, DCCPS, NCI
|11:15 a.m. - 11:45 a.m.||
The Role of Epidemiology in Knowledge Integration and Meta-Research [ PDF (1.1 MB), HTML ]
John Ioannidis, M.D., D.Sc
|11:45 a.m. - 12:45 p.m.||
Panel and Audience Discussion [ PDF (538 KB), HTML ]
Katrina Goddard, Ph.D.
Robert A. Hiatt, M.D., Ph.D.
Ann Zauber, Ph.D.
|12:45 p.m. - 1:15 p.m.||Lunch|
Session 6: Where Do We Go From Here? 12 Recommendations for Epidemiology in the Next 10-20 Years
Moderator: Patricia Hartge, Sc.D., DCEG, NCI
|1:15 p.m. - 2:30 p.m.||Working lunch and moderated discussion to come up with 12 broad recommendations for action in the next 10-20 years|
The meeting offered several ways for the research community to participate online. The proceedings were videocast live from http://videocast.nih.gov. The archived videocasts are available at the links below:
Online participants were invited to share their comments and questions via Twitter (by using the meeting hashtag, #trendsinepi, or @NCIEpi in their tweets) or email (email@example.com). Select questions from online participants were then used in the question and answer portions of the workshop sessions.
Workshop Recommendations and Summary
Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse during the workshop. While the recommendations listed below are focused on cancer epidemiology, EGRP believes they apply broadly to the field of epidemiology and will serve as a strong scientific foundation to accelerate translation of scientific discoveries into individual and population health benefits. What follows are brief descriptions of all eight recommendations; a more comprehensive discussion of these recommendations and their foundations can be found in the April 2013 issue of Cancer Epidemiology, and Biomarkers and Prevention.
Recommendation #1: Extend the reach of epidemiology to include development and evaluation of clinical and population interventions, implementation, dissemination, and outcomes research.
Recommendation #2: Increase access to data, metadata, and specimens to foster collaboration, ensure reproducibility and replication, and accelerate translation to population health impact.
Recommendation #3: Expand cohort studies across the lifespan and include multiple health outcomes.
Recommendation #4: Develop, evaluate, and use novel technologies to quantify exposures and outcomes on a large scale and assess multiple factors in complex diseases.
Recommendation #5: Develop systematic approaches to manage, analyze, display, and interpret large, complex datasets.
Recommendation #6: Expand knowledge integration to drive research, policy, and practice.
Recommendation #7: Transform epidemiology training by emphasizing team science, multilevel analyses, knowledge integration, and translation.
Recommendation #8: Develop and design rational, cost-effective resources to optimize funding for epidemiology studies, accelerate translation, and maximize health impact.
View full workshop summary. [PDF - 1.8 MB]
- Workshop Commentary: Khoury MJ, Lam TK, Ioannidis JPA et al. Transforming Epidemiology for 21st Century Medicine and Public Health. Cancer Epidemiol Biomarkers Prev. [Epub ahead of print]
- Selected Bibliography
- Cancer Epidemiology, Biomarkers and Prevention special series of commentaries: Cancer Epidemiology in the 21st Century
Workshop Planning Committee:
- Muin Khoury, M.D., Ph.D., Acting Associate Director, EGRP, Division of Cancer Control and Population Sciences (DCCPS), NCI
- Robert Hoover, M.D., Sc.D., Director, Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, NCI
- Timothy Rebbeck, Ph.D., Professor of Epidemiology, University of Pennsylvania
- Sheri Schully, Ph.D., Knowledge Integration Team Lead, EGRP, DCCPS, NCI
EGRP Workshop Advisory Group:
- Rao Divi, Ph.D., Program Director, Methods and Technologies Branch
- Joanne Elena, Ph.D., M.P.H., Program Director, Clinical and Translational Epidemiology Branch
- Christie Kaefer, M.B.A., R.D., Communications Coordinator, Office of the Associate Director
- Tram Lam, Ph.D., M.P.H., Program Director, Knowledge Integration Team, Office of the Associate Director
- Stefanie Nelson, Ph.D., Program Director, Genomic Epidemiology Branch