NCI Gene-Environment Think-Tank

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Overview
Agenda
Workshop Summary
Additional Resources

Overview

Risk of cancer is determined by a complex interplay of genetic and environmental factors. Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with cancer. However, it remains unclear how to best incorporate gene-environment interplay into study design and analysis in order to better understand cancer etiology, or to identify public health interventions.

NCI's Epidemiology and Genomics Research Program (EGRP) sponsored a Gene-Environment Think-Tank on January 10-11, 2012 in Rockville, MD.

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The objective was to facilitate discussions on the:

goals of gene-environment interaction studies in cancer epidemiology;
state of the science of gene-environment interactions; and
opportunities for the future, including novel study design and analysis tools.

Topics covered included presentations on summary results from large consortia studies of breast, lung, colon, and bladder cancer; review of current statistical methods; and discussion of challenges in the field. The Think-Tank expanded on earlier discussions about gene-environment interactions made at the September 2010 Workshop on Next-Generation Analytic Tools for Large-Scale Genetic Epidemiology Studies of Complex Diseases.

Agenda

View Agenda for Day 1 of the Think Tank

January 10	Topic
12:30 p.m.	Welcome Muin Khoury, M.D., Ph.D. Epidemiology and Genomics Research Program Division of Cancer Control and Population Sciences (DCCPS) National Cancer Institute (NCI)
12:35 p.m.	Introduction to Meeting Leah Mechanic, Ph.D., M.P.H. Genomic Epidemiology Branch Epidemiology and Genomics Research Program, DCCPS, NCI
12:45 p.m.	Goals of Gene-Environment Interaction Studies in Cancer Epidemiology Nilanjan Chatterjee, Ph.D. Division of Cancer Epidemiology and Genetics, NCI
1:00 p.m.	State of the Science - Short Presentations What has been learned from studies of recognized gene-environment interactions? Have epidemiologic studies used gene-environment interaction to uncover new loci, modifiable risk factors, or biological insights into cancer etiology and outcomes? (i.e., What has been found? What are current strategies? What are alternate strategies for the future?) Are we asking the right questions?
1:00 p.m.	Breast Cancer Peter Kraft, Ph.D. Harvard School of Public Health
1:20 p.m.	Colorectal Cancer Ulrike Peters, Ph.D. Fred Hutchinson Cancer Research Center
1:40 p.m.	Lung Cancer Christopher Amos, Ph.D. The University of Texas MD Anderson Cancer Center
2:00 p.m.	Bladder Cancer Nathaniel Rothman, M.D., M.P.H., M.H.S. Division of Cancer Epidemiology and Genetics, NCI
2:20 p.m.	Glioma Melissa Bondy, Ph.D. Baylor College of Medicine
2:40 p.m.	Knowledge Management and Synthesis Paolo Boffetta, Ph.D. The Mount Sinai Hospital
3:20 p.m.	Group Discussion: State of the Science Discussion expanding upon presented data, data not presented, and other cancer types Panel: Peter Kraft, Ph.D., Harvard School of Public Health Ulrike Peters, Ph.D., Fred Hutchinson Cancer Research Center Christopher Amos, Ph.D., MD Anderson Cancer Center Nathaniel Rothman, M.D., M.P.H., M.H.S., Division of Cancer Epidemiology and Genetics, NCI Melissa Bondy, Ph.D., Baylor College of Medicine Paolo Boffetta, Ph.D., The Mount Sinai Hospital Moderator: Elizabeth Gillanders, Ph.D., Genomic Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI Facilitators: Naoko Simonds, Sc.D., Clinical and Translational Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI Carolyn Hutter, Ph.D., Fred Hutchinson Cancer Research Center
4:20 p.m.	Methodological Challenges and Opportunities - Analytical Methods
4:20 p.m.	Emerging Approaches for Gene-Environment Wide Association Studies Duncan Thomas, Ph.D. Keck School of Medicine of the University of Southern California
4:40 p.m.	Beyond Logistic Regression and Case-Only Tests Clarice Weinberg, Ph.D. National Institute of Environmental Health Sciences
5:00 p.m.	Group Discussion: Analytical Methods Panel Duncan Thomas, Ph.D., Keck School of Medicine Clarice Weinberg, Ph.D., National Institute of Environmental Health Sciences Peter Kraft, Ph.D., Harvard School of Public Health Moderator: Nilanjan Chatterjee, Ph.D., Division of Cancer Epidemiology and Genetics, NCI Facilitators: Kimberly McAllister, Ph.D., National Institute of Environmental Health Sciences Jim Gauderman, Ph.D., University of Southern California

View Agenda for Day 2 of the Think Tank

January 11	Topic
8:00 a.m.	Introduction to Day 2 Leah Mechanic, Ph.D., M.P.H. Genomic Epidemiology Branch Epidemiology and Genomics Research Program, DCCPS, NCI
8:10 a.m.	Methodological Challenges and Opportunities - Measurement or Assessment of the Environment
8:10 a.m.	Exposure Measurement Error in Complex Studies, Some Basic Principles and Relevant Examples Daniel O. Stram, Ph.D. Keck School of Medicine of the University of Southern California
8:30 a.m.	Challenges of Exposure Assessment and Measurement Error in Studies of GxE Interaction Donna Spiegelman, Ph.D. Harvard School of Public Health
8:50 a.m.	Novel Methodologies for Exposure Assessment - Report from Genes Environment and Health Initiative (GEI) Exposure Biology Program David Balshaw, Ph.D. National Institute of Environmental Health Sciences
9:10 a.m.	Time Varying Exposure Metrics and Timing of Exposure Effects Molin Wang, Ph.D. Harvard School of Public Health
9:50 a.m.	Group Discussion: Measurement or Assessment of the Environment Panel: Daniel O. Stram, Ph.D., Keck School of Medicine Donna Spiegelman, Ph.D., Harvard School of Public Health David Balshaw, Ph.D., National Institute of Environmental Health Sciences Molin Wang, Ph.D., Harvard School of Public Health Moderator: Kimberly McAllister, Ph.D., National Institute of Environmental Health Sciences Facilitators: Gary Ellison, Ph.D., Environmental Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI Daniel Shaughnessy, Ph.D., National Institute of Environmental Health Sciences
10:50 a.m.	Methodological Challenges and Opportunities - Study Designs and Approaches
11:10 a.m.	Opportunities for Study in Diverse Populations Christian Abnet, Ph.D. Division of Cancer Epidemiology and Genetics, NCI
11:30 a.m.	Epigenetics Studies for Gene-Environment Margaret Daniele Fallin, Ph.D. The Johns Hopkins University
11:50 a.m.	Opportunities for Study of Gene-Environment in Cancer Laura Jean Bierut, M.D. Washington University
1:10 p.m.	Group Discussion: Study Designs and Approaches Panel: Christian Abnet, Ph.D., Division of Cancer Epidemiology and Genetics, NCI Margaret Daniele Fallin, Ph.D., The Johns Hopkins University Laura Jean Bierut, M.D., Washington University Moderator: Nancy Cox, Ph.D., University of Chicago Facilitators: Jill Reedy, Ph.D., Applied Research Program Sheri Schully, Ph.D., Genomic Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI
2:10 p.m.	Clinical and Public Health Implications
2:10 p.m.	Application of GxE to Cancer Prevention Studies Ross Prentice, Ph.D. Fred Hutchinson Cancer Research Center
3:00 p.m.	Group Discussion: Discussion and Meeting Summation Overview and discussion of controversial issues raised during course of meeting Where do we go from here? Panel: Nilanjan Chatterjee, Ph.D., Division of Cancer Epidemiology and Genetics, NCI Margaret Daniele Fallin, Ph.D., The Johns Hopkins University Peter Kraft, Ph.D., Harvard School of Public Health Nathaniel Rothman, M.D., M.P.H., M.H.S., Division of Cancer Epidemiology and Genetics, NCI John Witte, Ph.D., University of California, San Francisco Moderator: Stephen Chanock, M.D., Division of Cancer Epidemiology and Genetics, NCI
4:00 p.m.	Group Discussion: Meeting Conclusions What can NCI and NIH do to facilitate research in genes and environment? Moderator: Peter Kraft, Ph.D., Harvard School of Public Health

Workshop Summary

Hutter CM, Mechanic LE, Chatterjee N, Kraft P, Gillanders EM, on behalf of NCI Gene-Environment Think Tank. Gene-Environment Interactions in Cancer Epidemiology: A National Cancer Institute Think Tank Report. Genet Epidemiol. 2013 Nov;37(7):643-657. [Epub 2013 Oct 5]

Additional Resources

Gene-Environment Research and Cancer Epidemiology
Further information about the Epidemiology and Genomics Research Program's (EGRP) interests in gene-environment research; related funding opportunities (when available) and funded research projects; links to related research resources, scientific publications, workshops, a discussion group, and EGRP staff contact information.

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Last Updated: 02 Mar, 2020