Using Immune Marker Panels to Uncover the Role of Inflammation in Cancer

June 4-5, 2014 in Rockville, MD

Overview

The 1.5-day "Using Immune Marker Panels to Uncover the Role of Inflammation in Cancer" workshop was sponsored by the Epidemiology and Genomics Research Program (EGRP) in NCI's Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Epidemiology and Genetics (DCEG). Representatives from institutions involved in studies of inflammation and cancer using technologies to assay inflammatory proteins were invited to share their experiences with new technologies and findings from association studies. At the end of the workshop, participants defined areas of consensus, and identified and summarized knowledge gaps.

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Carol Weil, J.D.
Program Director, Ethical and Regulatory Affairs
Cancer Diagnosis Program
Division of Cancer Treatment and Diagnosis
carol.weil@nih.gov

  • Danielle Carrick
  • Allan Hildesheim
  • Agenda

    The workshop sessions included discussion of disease associations, biological interpretation of findings, assay performance, and statistical considerations.

    View agenda for Wednesday, June 4

    June 4, 2014 Topic
    8:15 a.m. Registration
    8:30 a.m.

    Welcome
    Mukesh Verma, Ph.D.
    EGRP, DCCPS, NCI

    Allan Hildesheim, Ph.D.
    DCEG, NCI

    Session 1: Ongoing Studies With Inflammatory Marker Panel Assays and Disease Associations in Prospective Cohorts
    Chairs: Anil Chaturvedi, Ph.D., DCEG, NCI and Meredith Shiels, Ph.D., M.H.S., DCEG, NCI
    9:00 a.m. Introduction to the Session
    Anil Chaturvedi, Ph.D.
    DCEG, NCI
    9:05 a.m. Studies Within NCI Cohorts—Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study
    Mark Purdue, Ph.D.
    DCEG, NCI
    9:25 a.m. Cytokines Associated With Development of Cirrhosis and Hepatocellular Carcinoma in Patients With Chronic Hepatitis
    Hwai-I Yang, Ph.D.
    Academia Sinica
    9:45 a.m. Studies in the California Birth Cohort
    Joseph Wiemels, Ph.D.
    University of California, San Francisco
    10:05 a.m. Break
    10:20 a.m. Studies in the Women's Health Initiative Cohort
    Gloria Ho, Ph.D., M.P.H.
    Albert Einstein College of Medicine
    10:40 a.m. Studies in the International Agency for Research on Cancer (IARC) and European Studies
    Mattias Johansson, Ph.D.
    IARC
    11:00 a.m. Studies in the Vanderbilt Cohorts
    Wei Zheng, M.D., Ph.D.
    Vanderbilt University
    11:20 a.m. Studies on Epidemiologic Correlates of Inflammation Marker Levels
    Dr. Shiels
    DCEG, NCI
    11:40 a.m. Panel Discussion
    12:30 p.m. Lunch
    Session 2: Biologic Interpretation of Marker Association Studies
    Chair: Ron Germain, M.D., Ph.D., National Institute of Allergy and Infectious Diseases (NIAID)
    1:00 p.m. Introduction to the Session
    Ron Germain, M.D., Ph.D.
    National Institute of Allergy and Infectious Diseases (NIAID)
    1:10 p.m. Immunologic Perspectives on Exposure/Disease Associations in Epidemiologic Studies - Soluble Receptors and Cytokines
    Daniel McVicar, Ph.D.
    Center for Cancer Research, NCI
    1:30 p.m. Immunologic Perspectives on Exposure/Disease Associations in Epidemiologic Studies - Chemokines
    Joshua Farber, M.D.
    NIAID
    1:50 p.m. Local Versus Systemic Markers of Inflammation
    Ron Germain, M.D., Ph.D.
    National Institute of Allergy and Infectious Diseases (NIAID)
    2:10 p.m. Panel Discussion
    3:10 p.m. Break
    Session 3: State of the Science on Multiplexed Inflammation Marker Platforms/Assays
    Chair: Ligia Pinto, Ph.D., Leidos
    3:30 p.m. Introduction to the Session
    Ligia Pinto, Ph.D.
    Leidos
    3:40 p.m. An Overview of Approaches for Detection of Immune Markers in Serum and Plasma
    Phil McCoy, Ph.D.
    National Heart, Lung, and Blood Institute (NHLBI)
    4:00 p.m. Multiplexed Immunometric Assays for the Quantification of Biomarkers of Inflammation: Stability, Reproducibility, and Selection of Biomarkers
    Otoniel Martinez-Maza, Ph.D.
    University of California, Los Angeles
    4:20 p.m. Standardization of Multiplex Assays and Evaluation of Performance
    Jay Bream, Ph.D.
    The Johns Hopkins University
    4:40 p.m. Panel Discussion
    5:30 p.m. Wrap Up
    5:40 p.m. Adjournment

    View agenda for Thursday, June 5

    June 5, 2014 Topic
    Session 4: Statistical issues in MIP Studies
    Chair: Ruth Pfeiffer, Ph.D., DCEG, NCI
    8:15 a.m. Introduction to the Session
    Ruth Pfeiffer, Ph.D.
    DCEG, NCI
    8:20 a.m. Conceptual and Inferential Considerations in the Design and Analysis of Circulating Inflammatory Markers in Relation to Cancer Incidence and Outcomes
    Elizabeth Platz, Sc.D.
    The Johns Hopkins University
    8:40 a.m. Assessing Assay Reproducibility and the Impact of Measurement Errors on Epidemiological Analyses
    Hormuzd Katki, Ph.D.
    DCEG, NCI
    9:00 a.m. Dimensionality Reduction Methods for Multivariate Cytokines Data
    Ravi Varadhan, Ph.D.
    The Johns Hopkins University
    9:20 a.m. Panel Discussion
    10:00 a.m. Break
    Session 5: Break-Out Groups and Wrap-Up Session
    Chairs: Drs. Verma and Hildesheim
    10:20 a.m. Break-Out Groups
    3 break-out groups were formed to discuss what we have learned from this meeting about the state of the science, gaps, and research strategies for the future.
    1. Laboratory Methods
      Moderator: Dr. Pinto
    2. Epidemiological Studies and Statistical Considerations
      Moderator: Dr. Shiels
    3. Epidemiology-Immunology Interface
      Moderator: Dr. Hildesheim
    Workshop Wrap-Up and Discussion of Future Needs
    11:20 a.m. Laboratory Methods: Future Needs
    Dr. Pinto, Rapporteur
    11:35 a.m. Epidemiological Studies and Statistical Considerations: Future Needs
    Dr. Shiels, Rapporteur
    11:50 a.m. Epidemiology-Immunology Interface, Functional studies: Future needs
    Dr. Hildesheim, Rapporteur
    12:05 p.m. Conclusion and Recommendations
    12:20 p.m. Adjournment

    Workshop Summary

    Carrick DM, Chaturvedi AK, Shiels MS, Divi RL, Filipski KK, Hebert EF, Verma M, Hildesheim A. Using Immune Marker Panels to Evaluate the Role of Inflammation in Cancer: Summary of an NCI-sponsored Workshop. Cancer Epidemiol Biomarkers Prev. 2015 Jun 24.

    Planning Committee