Personal Genomics: Establishing the Scientific Foundation for Using Personal Genome Profiles for Risk Assessment, Health Promotion, and Disease Prevention
December 17-18, 2008
Bethesda North Marriott, Bethesda, Maryland
This 2-day workshop, cosponsored by CDC and NIH, explored the type of scientific foundation that is crucially needed to make the promise of personal genomics a reality. The workshop participants examined how the integration of genomics into personalized health can follow an evidence-based process. The process for using genomic applications in personalized healthcare (e.g. pharmacogenomics, early detection markers, testing in clinical trials) was discussed.
A multidisciplinary working group reviewed and discussed the scientific basis for using genomic profiles in risk assessment and disease prevention, identified gaps in knowledge, and explored how those gaps in our knowledge base can be filled through research. The participants addressed –from consumer and provider perspectives–the scientific information needed to evaluate and interpret results of genomic profiles and their added value to promote health and prevent common diseases compared to traditional nongenetic approaches. A published peer-reviewed paper will summarize the discussion and recommendations for a multidisciplinary research agenda. This paper will be used to disseminate the information to providers and consumers.
Meeting Folder Materials
- Letting the Genome out of the Bottle- Will We Get Our Wish?
- A Critical Appraisal of the Scientific Basis of Commercial Genomic Profiles Used to Assess Health Risks and Personalize Health Interventions
- The Genome Gets Personal- Almost
- Genomic Profiles for Disease Risk: Predictive or Premature?
- Putting science over supposition in the arena of personalized genomics
Khoury MJ, McBride CM, Schully SD, Ioannidis JP, Feero WG, Janssens AC, Gwinn M, Simons-Morton DG, Bernhardt JM, Cargill M, Chanock SJ, Church GM, Coates RJ, Collins FS, Croyle RT, Davis BR, Downing GJ, Duross A, Friedman S, Gail MH, Ginsburg GS, Green RC, Greene MH, Greenland P, Gulcher JR, Hsu A, Hudson KL, Kardia SL, Kimmel PL, Lauer MS, Miller AM, Offit K, Ransohoff DF, Roberts JS, Rasooly RS, Stefansson K, Terry SF, Teutsch SM, Trepanier A, Wanke KL, Witte JS, Xu J. The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med. 2009 Aug;11(8):559-67.