Understanding the Role of Muscle and Body Composition in Studies of Cancer Risk and Prognosis in Cancer Survivors

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Overview
Agenda
Planning Committee

Overview

The National Cancer Institute's Epidemiology and Genomics Research Program (EGRP) hosted a workshop, "Understanding the Role of Muscle and Body Composition in Studies of Cancer Risk and Prognosis in Cancer Survivors," on September 25-26, 2017, in the NIH Conference Center at 5635 Fishers Lane in Rockville, MD.

The purpose of this workshop was to bring together scientists to discuss current research examining how body composition affects cancer outcomes and identify the research needed to inform recommendations for cancer survivors. The workshop identified key methodological challenges and approaches to optimize measurement and analysis, by building on past examples studying sarcopenia, cachexia, and frailty in aging populations, to better understand the implications for cancer survivors.

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Agenda & Links to Presentations

View agenda for Monday, September 25

Time	Topic
8:30 a.m. - 8:45 a.m.	Registration
8:45 a.m. - 9:00 a.m.	Welcome Robert Croyle, PhD National Cancer Institute
9:00 a.m. - 9:30 a.m.	Overview of Workshop Joanne Elena, PhD, MPH National Cancer Institute
9:30 a.m. - 10:00 a.m.	Evidence of the import of sarcopenia and other measures of body composition on cancer survival Bette Caan, DrPH Kaiser Permanente Northern California
10:00 a.m. - 10:30 a.m.	Body composition and adverse outcomes in cancer survivors: a review of suggested explanations Shlomit Strulov Shachar, MD University of North Carolina at Chapel Hill
10:30 a.m. - 10:45 a.m.	Discussion
10:45 a.m. - 11:00 a.m.	Break
11:00 a.m. - 11:20 a.m.	Lean mass and muscle physiology Luigi Ferrucci, MD, PhD National Institute on Aging
11:20 a.m. - 11:40 a.m.	Fatty infiltration into muscle and fibrotic tissue in adipose tissue: its relation to inflammation Tamara Harris, MD, MS National Institute on Aging
11:40 a.m. - 12:00 p.m.	Breast adipose inflammation: a silent killer Andrew Dannenberg, MD Cornell University
12:00 p.m. - 12:15 p.m.	Discussion
12:15 p.m. - 1:15 p.m.	Poster Session and Lunch (Cafeteria on site)
1:15 p.m. - 1:35 p.m.	Will current data-driven approaches/background of sarcopenia help us? Peggy M. Cawthon, PhD, MPH University of California San Francisco and California Pacific Medical Center
1:35 p.m. - 1:55 p.m.	Different cutpoints/landmarks: finding meaningful cutpoints to predict those at risk for poor outcomes Vickie Baracos, PhD University of Alberta
1:55 p.m. - 2:15 p.m.	Measuring function in cancer patients with sarcopenia: do we need disease- or sarcopenic-specific measures? Linda Woodhouse, PhD University of Alberta
2:15 p.m. - 2:35 p.m.	Applying what we've learned from clinical trials about cachexia to cancer survivors Jeffrey Crawford, MD Duke Cancer Institute
2:35 p.m. - 3:00 p.m.	Panel Discussion
3:00 p.m. - 3:15 p.m.	Break
3:15 p.m. - 3:45 p.m.	The sarcopenic phenotypes: overview and role of body composition quantification methods Steven Heymsfield, MD Louisiana State University
3:45 p.m. - 4:10 p.m.	Measuring body composition/sarcopenia in large studies using anthropometry and BIA June Stevens, PhD University of North Carolina at Chapel Hill
4:10 p.m. - 4:35 p.m.	DXA new functions and algorithms for lean mass: experimenting with different approaches John Shepherd, PhD, CCD University of California San Francisco
4:35 p.m. - 5:00 p.m.	Using ultrasound technology to measure sarcopenia Marina Mourtzakis, PhD University of Waterloo
5:00 p.m. - 5:30 p.m.	Panel Discussion

View agenda for Tuesday, September 26

Time	Topic
8:30 a.m. - 8:45 a.m.	Welcome Joanne Elena, PhD, MPH National Cancer Institute
8:45 a.m. - 9:10 a.m.	Nutritional interventions: optimal strategies for reducing adiposity while maintaining muscle mass Carla Prado, PhD, RD University of Alberta
9:10 a.m. – 9:35 a.m.	Exercise therapy to improve muscle quantity and quality in cancer survivors Jessica Scott, PhD Memorial Sloan Kettering Cancer Center
9:35 a.m. – 10:00 a.m.	Where are the gaps? What research do we need to inform guidelines for clinicians? Wendy Chen, MD, MPH Harvard University
10:00 a.m. – 10:30 a.m.	Discussion
10:30 a.m. - 10:40 a.m.	Break
10:45 a.m. – 11:45 a.m.	Panel Discussion: Identification of Research Opportunities and Gaps Moderator: Lisa Gallicchio, PhD, National Cancer Institute Setting Priorities for Future Directions of Research Panel Discussion Steven Heymsfield, MD, Louisiana State University Bette Caan, DrPH, Kaiser Permanente Northern California Shlomit Strulov Shachar, MD, University of North Carolina at Chapel Hill Tamara Harris, MD, MS, National Institute on Aging Carla Prado, PhD, RD, University of Alberta
11:45 a.m. – 12:00 p.m.	Lessons learned from transdisciplinary research in energetics and cancer Linda Nebeling, PhD, MPH, RD, FAND National Cancer Institute
12:00 p.m. – 1:00 p.m.	Lunch (Cafeteria on site)
1:00 p.m. – 2:30 p.m.	Open Discussion on the Future Directions of Research Opportunity for meeting attendees to discuss the gaps in research and identify key future directions. Please come prepared with ideas to discuss. A summary of this discussion will be reflected in the final meeting report. Sample Questions: What are critical areas or research gaps remaining? Can we prioritize the immediate research questions that need to be answered? What are the resources (data, tools, and methodologies) needed to answer these questions? What can we learn from other disciplines and diseases to advance research for cancer patients and survivors? How do we translate research results to the clinic and the patient and survivor community? Other questions?
2:30 p.m. – 3:00 p.m.	Wrap up/Adjourn Joanne Elena, PhD, MPH National Cancer Institute

*Permission has been given by the presenters to link to workshop videos.

Planning Committee

Bette Caan, DrPH , Kaiser Permanente Northern California
Joanne Elena, PhD, MPH, National Cancer Institute
Lisa Gallicchio PhD, National Cancer Institute
Tamara Harris, MD, MS, National Institute on Aging
Steven Heymsfield, MD , Louisiana State University
Carla Prado, PhD, RD , University of Alberta
Sharon Ross, PhD, MPH, National Cancer Institute
Shlomit Strulov Shachar, MD, University of North Carolina Chapel Hill
Elaine Trujillo, MS, RD, National Cancer Institute

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Last Updated: 15 Mar, 2023