September 25-26, 2017, NIH, Rockville, MD

Understanding the Role of Muscle and Body Composition in Studies of Cancer Risk and Prognosis in Cancer Survivors


The National Cancer Institute's Epidemiology and Genomics Research Program (EGRP) hosted a workshop, "Understanding the Role of Muscle and Body Composition in Studies of Cancer Risk and Prognosis in Cancer Survivors," on September 25-26, 2017, in the NIH Conference Center at 5635 Fishers Lane in Rockville, MD.

The purpose of this workshop was to bring together scientists to discuss current research examining how body composition affects cancer outcomes and identify the research needed to inform recommendations for cancer survivors. The workshop identified key methodological challenges and approaches to optimize measurement and analysis, by building on past examples studying sarcopenia, cachexia, and frailty in aging populations, to better understand the implications for cancer survivors.

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View agenda for Monday, September 25
Time Topic
8:30 a.m. - 8:45 a.m. Registration
8:45 a.m. - 9:00 a.m.

Robert Croyle, Ph.D.
National Cancer Institute

9:00 a.m. - 9:30 a.m.

Overview of Workshop
Joanne Elena, Ph.D., M.P.H.
National Cancer Institute

9:30 a.m. - 10:00 a.m.

Evidence of the import of sarcopenia and other measures of body composition on cancer survival
Bette Caan, Dr.P.H.
Kaiser Permanente Northern California

10:00 a.m. - 10:30 a.m.

Body composition and adverse outcomes in cancer survivors: a review of suggested explanations
Shlomit Strulov Shachar, M.D.
University of North Carolina at Chapel Hill

10:30 a.m. - 10:45 a.m. Discussion
10:45 a.m. - 11:00 a.m. Break
11:00 a.m. - 11:20 a.m.

Lean mass and muscle physiology
Luigi Ferrucci, M.D., Ph.D.
National Institute on Aging

11:20 a.m. - 11:40 a.m.

Fatty infiltration into muscle and fibrotic tissue in adipose tissue: its relation to inflammation
Tamara Harris, M.D., M.S.
National Institute on Aging

11:40 a.m. - 12:00 p.m.

Breast adipose inflammation: a silent killer
Andrew Dannenberg, M.D.
Cornell University

12:00 p.m. - 12:15 p.m. Discussion
12:15 p.m. - 1:15 p.m. Poster Session and Lunch (Cafeteria on site)
1:15 p.m. - 1:35 p.m.

Will current data-driven approaches/background of sarcopenia help us?
Peggy M. Cawthon, Ph.D., M.P.H.
University of California San Francisco and California Pacific Medical Center

1:35 p.m. - 1:55 p.m.

Different cutpoints/landmarks: finding meaningful cutpoints to predict those at risk for poor outcomes
Vickie Baracos, Ph.D.
University of Alberta

1:55 p.m. - 2:15 p.m.

Measuring function in cancer patients with sarcopenia: do we need disease- or sarcopenic-specific measures?
Linda Woodhouse, Ph.D.
University of Alberta

2:15 p.m. - 2:35 p.m.

Applying what we've learned from clinical trials about cachexia to cancer survivors
Jeffrey Crawford, M.D.
Duke Cancer Institute

2:35 p.m. - 3:00 p.m. Panel Discussion
3:00 p.m. - 3:15 p.m. Break
3:15 p.m. - 3:45 p.m.

The sarcopenic phenotypes: overview and role of body composition quantification methods
Steven Heymsfield, M.D.
Louisiana State University

3:45 p.m. - 4:10 p.m.

Measuring body composition/sarcopenia in large studies using anthropometry and BIA
June Stevens, Ph.D.
University of North Carolina at Chapel Hill

4:10 p.m. - 4:35 p.m.

DXA new functions and algorithms for lean mass: experimenting with different approaches
John Shepherd, Ph.D., C.C.D.
University of California San Francisco

4:35 p.m. - 5:00 p.m.

Using ultrasound technology to measure sarcopenia
Marina Mourtzakis, Ph.D.
University of Waterloo

5:00 p.m. - 5:30 p.m. Panel Discussion

View agenda for Tuesday, September 26
Time Topic
8:30 a.m. - 8:45 a.m.

Joanne Elena, Ph.D., M.P.H.
National Cancer Institute

8:45 a.m. - 9:10 a.m.

Nutritional interventions: optimal strategies for reducing adiposity while maintaining muscle mass
Carla Prado, Ph.D., R.D.
University of Alberta

9:10 a.m. – 9:35 a.m.

Exercise therapy to improve muscle quantity and quality in cancer survivors
Jessica Scott, Ph.D.
Memorial Sloan Kettering Cancer Center

9:35 a.m. – 10:00 a.m.

Where are the gaps? What research do we need to inform guidelines for clinicians?
Wendy Chen, M.D., M.P.H.
Harvard University

10:00 a.m. – 10:30 a.m. Discussion
10:30 a.m. - 10:40 a.m. Break
10:45 a.m. – 11:45 a.m.

Panel Discussion: Identification of Research Opportunities and Gaps
Moderator: Lisa Gallicchio, Ph.D., National Cancer Institute

Setting Priorities for Future Directions of Research Panel Discussion
Steven Heymsfield, M.D., Louisiana State University
Bette Caan, Dr.P.H., Kaiser Permanente Northern California
Shlomit Strulov Shachar, M.D., University of North Carolina at Chapel Hill
Tamara Harris, M.D., M.S., National Institute on Aging
Carla Prado, Ph.D., R.D., University of Alberta

11:45 a.m. – 12:00 p.m.

Lessons learned from transdisciplinary research in energetics and cancer
Linda Nebeling, PH.D., M.P.H., R.D., F.A.N.D.
National Cancer Institute

12:00 p.m. – 1:00 p.m. Lunch (Cafeteria on site)
1:00 p.m. – 2:30 p.m.

Open Discussion on the Future Directions of Research
Opportunity for meeting attendees to discuss the gaps in research and identify key future directions. Please come prepared with ideas to discuss. A summary of this discussion will be reflected in the final meeting report.

Sample Questions:
What are critical areas or research gaps remaining?
Can we prioritize the immediate research questions that need to be answered?
What are the resources (data, tools, and methodologies) needed to answer these questions?
What can we learn from other disciplines and diseases to advance research for cancer patients and survivors?
How do we translate research results to the clinic and the patient and survivor community?
Other questions?

2:30 p.m. – 3:00 p.m.

Wrap up/Adjourn
Joanne Elena, Ph.D., M.P.H.
National Cancer Institute

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Planning Committee

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For further information or questions, contact Joanne Elena, Ph.D., M.P.H., Program Director, Clinical and Translational Epidemiology Branch, Epidemiology and Genomics Research Program, NCI.

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