Research Highlights from EGRP Grantees - 2017

Research Highlights from EGRP Grantees - 2017

Research Highlights by EGRP Grantees

EGRP staff nominated and voted for manuscripts published in 2017 by EGRP grantees that were deemed to have the greatest potential scientific and/or public health impact. The final selections for EGRP's 2017 Research Highlights are presented below.

EGRP funds research in human populations to understand determinants of cancer occurrence and outcomes. The Program is the largest funder of cancer epidemiology grants nationally and worldwide, awarding more than 240 grants and cooperative agreements annually. View a full list of active EGRP grants.

The research featured below was funded in full or in part by EGRP:

Blood Cancer

In Utero Cytomegalovirus Infection and Development of Childhood Acute Lymphoblastic Leukemia

Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In Utero Cytomegalovirus Infection and Development of Childhood Acute Lymphoblastic LeukemiaBlood. 2017 Mar 23;129(12):1680-1684.

This research was funded by an EGRP grant to Joseph Leo Wiemels, Ph.D., of the University of California, San Francisco.


Breast Cancer

Cis-eQTL-Based Trans-Ethnic Meta-Analysis Reveals Novel Genes Associated with Breast Cancer Risk

Hoffman JD, Graff RE, Emami NC, Tai CG, Passarelli MN, Hu D, Huntsman S, Hadley D, Leong L, Majumdar A, Zaitlen N, Ziv E, Witte JS. Cis-eQTL-Based Trans-Ethnic Meta-Analysis Reveals Novel Genes Associated with Breast Cancer Risk. PLoS Genet. 2017 Mar 31;13(3):e1006690.

This research was funded by EGRP grants to the following: Christine B. Ambrosone, Ph.D., of the Roswell Park Comprehensive Cancer Center; Susan M. Gapstur, Ph.D., M.P.H., of the American Cancer Society, Inc.; Christopher Alan Haiman,Sc.D., of the University of Southern California; Brian E. Henderson, M.D., of the University of Southern California; David John Hunter, M.B.B.S., M.P.H., Sc.D., of the Brigham and Women's Hospital and Harvard University, School of Public Health; Esther M. John, Ph.D., M.S.P.H., of the Cancer Prevention Institute of California; Laurence N. Kolonel, Ph.D., of the University of Hawaii at Manoa; Loic Le Marchand, M.D., Ph.D., of the University of Hawaii at Manoa; Olufunmilayo F. Olopade, M.D., F.A.C.P., of the University of Chicago; Elio Riboli, M.D., M.P.H., M.S., of the University of London Imperial College; Xiao-Ou Shu, M.D., Ph.D., M.P.H., of Vanderbilt University; John S. Witte, Ph.D., University of California, San Francisco; and Wei Zheng, M.D., Ph.D., M.P.H., of Vanderbilt University Medical Center.

Biology and Etiology of Young_Onset Breast Cancers among Premenopausal African American Women_Results from the AMBER Consortium

Chollet-Hinton L, Olshan AF, Nichols HB, Anders CK, Lund JL, Allott EH, Bethea TN, Hong CC, Cohen SM, Khoury T, Zirpoli GR, Borges VF, Rosenberg LA, Bandera EV, Ambrosone CB, Palmer JR, Troester MA. Biology and Etiology of Young_Onset Breast Cancers among Premenopausal African American Women_Results from the AMBER Consortium. Cancer Epidemiol Biomarkers Prev. 2017 Dec;26(12):1722-1729.

This research was funded by EGRP grants to the following: Christine B. Ambrosone, Ph.D., of the Roswell Park Comprehensive Cancer Center; Elisa V. Bandera, M.D., Ph.D., of the Rutgers Cancer Institute of New Jersey; Julie R. Palmer, Sc.D., of Boston University; and Lynn Rosenberg, Sc.D., of Boston University.

Regular and Low-Dose Aspirin, Other Non-Steroidal Anti-Inflammatory Medications and Prospective Risk of HER2-Defined Breast Cancer: The California Teachers Study

Clarke CA, Canchola AJ, Moy LM, Neuhausen SL, Chung NT, Lacey JV Jr, Bernstein L. Regular and Low-Dose Aspirin, Other Non-Steroidal Anti-Inflammatory Medications and Prospective Risk of HER2-Defined Breast Cancer: The California Teachers Study. Breast Cancer Res. 2017 May 1;19(1):52.

This research was funded by an EGRP grant to Leslie Bernstein, Ph.D., of the Beckman Research Institute and City of Hope.

Association Analysis Identifies 65 New Breast Cancer Risk Loci

Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, Lemaçon A, Soucy P, Glubb D, Rostamianfar A, Bolla MK, Wang Q, Tyrer J, Dicks E, Lee A, Wang Z, Allen J, Keeman R, Eilber U, French JD, Qing Chen X, Fachal L, McCue K, McCart Reed AE, Ghoussaini M, Carroll JS, Jiang X, Finucane H, Adams M, Adank MA, Ahsan H, Aittomäki K, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Arun B, Auer PL, Bacot F, Barrdahl M, Baynes C, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Børresen-Dale AL, Brand JS, Brauch H, Brennan P, Brenner H, Brinton L, Broberg P, Brock IW, Broeks A, Brooks-Wilson A, Brucker SY, Brüning T, Burwinkel B, Butterbach K, Cai Q, Cai H, Caldés T, Canzian F, Carracedo A, Carter BD, Castelao JE, Chan TL, David Cheng TY, Seng Chia K, Choi JY, Christiansen H, Clarke CL; NBCS Collaborators, Collée M, Conroy DM, Cordina-Duverger E, Cornelissen S, Cox DG, Cox A, Cross SS, Cunningham JM, Czene K, Daly MB, Devilee P, Doheny KF, Dörk T, Dos-Santos-Silva I, Dumont M, Durcan L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Ellberg C, Elvira M, Engel C, Eriksson M, Fasching PA, Figueroa J, Flesch-Janys D, Fletcher O, Flyger H, Fritschi L, Gaborieau V, Gabrielson M, Gago-Dominguez M, Gao YT, Gapstur SM, García-Sáenz JA, Gaudet MM, Georgoulias V, Giles GG, Glendon G, Goldberg MS, Goldgar DE, González-Neira A, Grenaker Alnæs GI, Grip M, Gronwald J, Grundy A, Guénel P, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hamann U, Hamel N, Hankinson S, Harrington P, Hart SN, Hartikainen JM, Hartman M, Hein A, Heyworth J, Hicks B, Hillemanns P, Ho DN, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Hou MF, Hsiung CN, Huang G, Humphreys K, Ishiguro J, Ito H, Iwasaki M, Iwata H, Jakubowska A, Janni W, John EM, Johnson N, Jones K, Jones M, Jukkola-Vuorinen A, Kaaks R, Kabisch M, Kaczmarek K, Kang D, Kasuga Y, Kerin MJ, Khan S, Khusnutdinova E, Kiiski JI, Kim SW, Knight JA, Kosma VM, Kristensen VN, Krüger U, Kwong A, Lambrechts D, Le Marchand L, Lee E, Lee MH, Lee JW, Neng Lee C, Lejbkowicz F, Li J, Lilyquist J, Lindblom A, Lissowska J, Lo WY, Loibl S, Long J, Lophatananon A, Lubinski J, Luccarini C, Lux MP, Ma ESK, MacInnis RJ, Maishman T, Makalic E, Malone KE, Kostovska IM, Mannermaa A, Manoukian S, Manson JE, Margolin S, Mariapun S, Martinez ME, Matsuo K, Mavroudis D, McKay J, McLean C, Meijers-Heijboer H, Meindl A, Menéndez P, Menon U, Meyer J, Miao H, Miller N, Taib NAM, Muir K, Mulligan AM, Mulot C, Neuhausen SL, Nevanlinna H, Neven P, Nielsen SF, Noh DY, Nordestgaard BG, Norman A, Olopade OI, Olson JE, Olsson H, Olswold C, Orr N, Pankratz VS, Park SK, Park-Simon TW, Lloyd R, Perez JIA, Peterlongo P, Peto J, Phillips KA, Pinchev M, Plaseska-Karanfilska D, Prentice R, Presneau N, Prokofyeva D, Pugh E, Pylkäs K, Rack B, Radice P, Rahman N, Rennert G, Rennert HS, Rhenius V, Romero A, Romm J, Ruddy KJ, Rüdiger T, Rudolph A, Ruebner M, Rutgers EJT, Saloustros E, Sandler DP, Sangrajrang S, Sawyer EJ, Schmidt DF, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Schumacher F, Schürmann P, Scott RJ, Scott C, Seal S, Seynaeve C, Shah M, Sharma P, Shen CY, Sheng G, Sherman ME, Shrubsole MJ, Shu XO, Smeets A, Sohn C, Southey MC, Spinelli JJ, Stegmaier C, Stewart-Brown S, Stone J, Stram DO, Surowy H, Swerdlow A, Tamimi R, Taylor JA, Tengström M, Teo SH, Beth Terry M, Tessier DC, Thanasitthichai S, Thöne K, Tollenaar RAEM, Tomlinson I, Tong L, Torres D, Truong T, Tseng CC, Tsugane S, Ulmer HU, Ursin G, Untch M, Vachon C, van Asperen CJ, Van Den Berg D, van den Ouweland AMW, van der Kolk L, van der Luijt RB, Vincent D, Vollenweider J, Waisfisz Q, Wang-Gohrke S, Weinberg CR, Wendt C, Whittemore AS, Wildiers H, Willett W, Winqvist R, Wolk A, Wu AH, Xia L, Yamaji T, Yang XR, Har Yip C, Yoo KY, Yu JC, Zheng W, Zheng Y, Zhu B, Ziogas A, Ziv E; ABCTB Investigators; ConFab/AOCS Investigators, Lakhani SR, Antoniou AC, Droit A, Andrulis IL, Amos CI, Couch FJ, Pharoah PDP, Chang-Claude J, Hall P, Hunter DJ, Milne RL, García-Closas M, Schmidt MK, Chanock SJ, Dunning AM, Edwards SL, Bader GD, Chenevix-Trench G, Simard J, Kraft P, Easton DF. Association Analysis Identifies 65 New Breast Cancer Risk Loci. Nature. 2017 Nov 2;551(7678):92-94.

This research was funded by EGRP grants to the following: Habibul Ahsan, M.D., MMedSc., of the University of Chicago; Hoda A. Anton-Culver, Ph.D., of the University of California-Irvine; Leslie Bernstein, Ph.D., of the Beckman Research Institute and City of Hope; William J. Blot, Ph.D., of Vanderbilt University; Fergus Joseph Couch, Ph.D., of Mayo Clinic Rochester; Christopher Alan Haiman,Sc.D., of the University of Southern California; Brian E. Henderson, M.D., of the University of Southern California; David John Hunter, M.B.B.S., M.P.H., Sc.D., of Harvard University, School of Public Health; Esther M. John, Ph.D., M.S.P.H., of the Cancer Prevention Institute of California; Laurence N. Kolonel, Ph.D., of the University of Hawaii at Manoa; James V. Lacey, Ph.D., M.P.H., of Beckman Research Institute and City of Hope; Loic Le Marchand, M.D., Ph.D., of the University of Hawaii at Manoa; Sara Lindstroem, Ph.D., M.S., of the University of Washington; Kathleen E. Malone, Ph.D., M.P.H., of the Fred Hutchinson Cancer Research Center; Meir Jonathan Stampfer, M.D., Dr.P.H., of Brigham and Women’s Hospital; Mary Beth Terry, Ph.D., of Columbia University; Celine M. Vachon, Ph.D., of Mayo Clinic Rochester; Walter C. Willett, M.D., Dr.P.H., of Harvard University; and Wei Zheng, M.D., Ph.D., M.P.H., of Vanderbilt University Medical Center.

Identification of Ten Variants Associated With Risk of Estrogen-Receptor Negative Breast Cancer

Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM; ABCTB Investigators, Adams M, Adlard J, Agata S, Ahmed S, Ahsan H, Aittomäki K, Al-Ejeh F, Allen J, Ambrosone CB, Amos CI, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Arnold N, Aronson KJ, Auber B, Auer PL, Ausems MGEM, Azzollini J, Bacot F, Balmaña J, Barile M, Barjhoux L, Barkardottir RB, Barrdahl M, Barnes D, Barrowdale D, Baynes C, Beckmann MW, Benitez J, Bermisheva M, Bernstein L, Bignon YJ, Blazer KR, Blok MJ, Blomqvist C, Blot W, Bobolis K, Boeckx B, Bogdanova NV, Bojesen A, Bojesen SE, Bonanni B, Børresen-Dale AL, Bozsik A, Bradbury AR, Brand JS, Brauch H, Brenner H, Bressac-de Paillerets B, Brewer C, Brinton L, Broberg P, Brooks-Wilson A, Brunet J, Brüning T, Burwinkel B, Buys SS, Byun J, Cai Q, Caldés T, Caligo MA, Campbell I, Canzian F, Caron O, Carracedo A, Carter BD, Castelao JE, Castera L, Caux-Moncoutier V, Chan SB, Chang-Claude J, Chanock SJ, Chen X, Cheng TD, Chiquette J, Christiansen H, Claes KBM, Clarke CL, Conner T, Conroy DM, Cook J, Cordina-Duverger E, Cornelissen S, Coupier I, Cox A, Cox DG, Cross SS, Cuk K, Cunningham JM, Czene K, Daly MB, Damiola F, Darabi H, Davidson R, De Leeneer K, Devilee P, Dicks E, Diez O, Ding YC, Ditsch N, Doheny KF, Domchek SM, Dorfling CM, Dörk T, Dos-Santos-Silva I, Dubois S, Dugué PA, Dumont M, Dunning AM, Durcan L, Dwek M, Dworniczak B, Eccles D, Eeles R, Ehrencrona H, Eilber U, Ejlertsen B, Ekici AB, Eliassen AH; EMBRACE, Engel C, Eriksson M, Fachal L, Faivre L, Fasching PA, Faust U, Figueroa J, Flesch-Janys D, Fletcher O, Flyger H, Foulkes WD, Friedman E, Fritschi L, Frost D, Gabrielson M, Gaddam P, Gammon MD, Ganz PA, Gapstur SM, Garber J, Garcia-Barberan V, García-Sáenz JA, Gaudet MM, Gauthier-Villars M, Gehrig A; GEMO Study Collaborators, Georgoulias V, Gerdes AM, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, González-Neira A, Goodfellow P, Greene MH, Alnæs GIG, Grip M, Gronwald J, Grundy A, Gschwantler-Kaulich D, Guénel P, Guo Q, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hallberg E, Hamann U, Hamel N, Hankinson S, Hansen TVO, Harrington P, Hart SN, Hartikainen JM, Healey CS; HEBON, Hein A, Helbig S, Henderson A, Heyworth J, Hicks B, Hillemanns P, Hodgson S, Hogervorst FB, Hollestelle A, Hooning MJ, Hoover B, Hopper JL, Hu C, Huang G, Hulick PJ, Humphreys K, Hunter DJ, Imyanitov EN, Isaacs C, Iwasaki M, Izatt L, Jakubowska A, James P, Janavicius R, Janni W, Jensen UB, John EM, Johnson N, Jones K, Jones M, Jukkola-Vuorinen A, Kaaks R, Kabisch M, Kaczmarek K, Kang D, Kast K; kConFab/AOCS Investigators, Keeman R, Kerin MJ, Kets CM, Keupers M, Khan S, Khusnutdinova E, Kiiski JI, Kim SW, Knight JA, Konstantopoulou I, Kosma VM, Kristensen VN, Kruse TA, Kwong A, Lænkholm AV, Laitman Y, Lalloo F, Lambrechts D, Landsman K, Lasset C, Lazaro C, Le Marchand L, Lecarpentier J, Lee A, Lee E, Lee JW, Lee MH, Lejbkowicz F, Lesueur F, Li J, Lilyquist J, Lincoln A, Lindblom A, Lissowska J, Lo WY, Loibl S, Long J, Loud JT, Lubinski J, Luccarini C, Lush M, MacInnis RJ, Maishman T, Makalic E, Kostovska IM, Malone KE, Manoukian S, Manson JE, Margolin S, Martens JWM, Martinez ME, Matsuo K, Mavroudis D, Mazoyer S, McLean C, Meijers-Heijboer H, Menéndez P, Meyer J, Miao H, Miller A, Miller N, Mitchell G, Montagna M, Muir K, Mulligan AM, Mulot C, Nadesan S, Nathanson KL; NBSC Collaborators, Neuhausen SL, Nevanlinna H, Nevelsteen I, Niederacher D, Nielsen SF, Nordestgaard BG, Norman A, Nussbaum RL, Olah E, Olopade OI, Olson JE, Olswold C, Ong KR, Oosterwijk JC, Orr N, Osorio A, Pankratz VS, Papi L, Park-Simon TW, Paulsson-Karlsson Y, Lloyd R, Pedersen IS, Peissel B, Peixoto A, Perez JIA, Peterlongo P, Peto J, Pfeiler G, Phelan CM, Pinchev M, Plaseska-Karanfilska D, Poppe B, Porteous ME, Prentice R, Presneau N, Prokofieva D, Pugh E, Pujana MA, Pylkäs K, Rack B, Radice P, Rahman N, Rantala J, Rappaport-Fuerhauser C, Rennert G, Rennert HS, Rhenius V, Rhiem K, Richardson A, Rodriguez GC, Romero A, Romm J, Rookus MA, Rudolph A, Ruediger T, Saloustros E, Sanders J, Sandler DP, Sangrajrang S, Sawyer EJ, Schmidt DF, Schoemaker MJ, Schumacher F, Schürmann P, Schwentner L, Scott C, Scott RJ, Seal S, Senter L, Seynaeve C, Shah M, Sharma P, Shen CY, Sheng X, Shimelis H, Shrubsole MJ, Shu XO, Side LE, Singer CF, Sohn C, Southey MC, Spinelli JJ, Spurdle AB, Stegmaier C, Stoppa-Lyonnet D, Sukiennicki G, Surowy H, Sutter C, Swerdlow A, Szabo CI, Tamimi RM, Tan YY, Taylor JA, Tejada MI, Tengström M, Teo SH, Terry MB, Tessier DC, Teulé A, Thöne K, Thull DL, Tibiletti MG, Tihomirova L, Tischkowitz M, Toland AE, Tollenaar RAEM, Tomlinson I, Tong L, Torres D, Tranchant M, Truong T, Tucker K, Tung N, Tyrer J, Ulmer HU, Vachon C, van Asperen CJ, Van Den Berg D, van den Ouweland AMW, van Rensburg EJ, Varesco L, Varon-Mateeva R, Vega A, Viel A, Vijai J, Vincent D, Vollenweider J, Walker L, Wang Z, Wang-Gohrke S, Wappenschmidt B, Weinberg CR, Weitzel JN, Wendt C, Wesseling J, Whittemore AS, Wijnen JT, Willett W, Winqvist R, Wolk A, Wu AH, Xia L, Yang XR, Yannoukakos D, Zaffaroni D, Zheng W, Zhu B, Ziogas A, Ziv E, Zorn KK, Gago-Dominguez M, Mannermaa A, Olsson H, Teixeira MR, Stone J, Offit K, Ottini L, Park SK, Thomassen M, Hall P, Meindl A, Schmutzler RK, Droit A, Bader GD, Pharoah PDP, Couch FJ, Easton DF, Kraft P, Chenevix-Trench G, García-Closas M, Schmidt MK, Antoniou AC, Simard J. Identification of Ten Variants Associated With Risk of Estrogen-Receptor Negative Breast Cancer. Nat Genet. 2017 Dec;49(12):1767-1778.

This research was funded by EGRP grants to the following: Christopher I. Amos, Ph.D., of Dartmouth University; Hoda A. Anton-Culver, Ph.D., of the University of California-Irvine; Leslie Bernstein, Ph.D., of the Beckman Research Institute and City of Hope; Fergus Joseph Couch, Ph.D., of Mayo Clinic Rochester; Ellen L. Goode, Ph.D., of Mayo Clinic Rochester; Christopher Alan Haiman, Sc.D., of the University of Southern California; Brian E. Henderson, M.D., of the University of Southern California; David John Hunter, M.B.B.S., M.P.H., Sc.D., of Harvard University, School of Public Health; Esther M. John, Ph.D., M.S.P.H., of the Cancer Prevention Institute of California; Laurence N. Kolonel, Ph.D., of the University of Hawaii at Manoa; James V. Lacey, Ph.D., M.P.H., of Beckman Research Institute and City of Hope; Loic Le Marchand, M.D., Ph.D., of the University of Hawaii at Manoa; Olufunmilayo F. Olopade, M.D., F.A.C.P., of the University of Chicago; Catherine M. Phelan, M.D., Ph.D., of the H. Lee Moffitt Cancer Center; Thomas A. Sellers, Ph.D., M.P.H., of the H. Lee Moffitt Cancer Center; Meir Jonathan Stampfer, M.D., Dr.P.H., of Brigham and Women’s Hospital; Celine M. Vachon, Ph.D., of Mayo Clinic Rochester; Jeffrey Weitzel, M.D., of the Beckman Research Institute and City of Hope; Dee Wayne West, Ph.D., Cancer Prevention Institute of California; Walter C. Willett, M.D., Dr.P.H., of Harvard University; and Wei Zheng, M.D., Ph.D., M.P.H., of Vanderbilt University Medical Center.


Lung Cancer

Large-Scale Association Analysis Identifies New Lung Cancer Susceptibility Loci and Heterogeneity in Genetic Susceptibility Across Histological Subtypes

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV; SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-Scale Association Analysis Identifies New Lung Cancer Susceptibility Loci and Heterogeneity in Genetic Susceptibility Across Histological Subtypes. Nat Genet. 2017 Jul;49(7):1126-1132.

This research was funded by EGRP grants to Christopher I. Amos, Ph.D., of Dartmouth University and Jennifer A. Doherty, Ph.D., of the Fred Hutchinson Cancer Research Center.


Multiple Cancers

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Kuchenbaecker KB, Hopper JL, Barnes DR, Phillips KA, Mooij TM, Roos-Blom MJ, Jervis S, van Leeuwen FE, Milne RL, Andrieu N, Goldgar DE, Terry MB, Rookus MA, Easton DF, Antoniou AC, BRCA1 and BRCA2 Cohort Consortium, McGuffog L, Evans DG, Barrowdale D, Frost D, Adlard J, Ong KR, Izatt L, Tischkowitz M, Eeles R, Davidson R, Hodgson S, Ellis S, Nogues C, Lasset C, Stoppa-Lyonnet D, Fricker JP, Faivre L, Berthet P, Hooning MJ, van der Kolk LE, Kets CM, Adank MA, John EM, Chung WK, Andrulis IL, Southey M, Daly MB, Buys SS, Osorio A, Engel C, Kast K, Schmutzler RK, Caldes T, Jakubowska A, Simard J, Friedlander ML, McLachlan SA, Machackova E, Foretova L, Tan YY, Singer CF, Olah E, Gerdes AM, Arver B, Olsson H. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA. 2017 Jun 20;317(23):2402-2416.

This research was funded by EGRP grants to Esther M. John, Ph.D., M.S.P.H., of the Cancer Prevention Institute of California and Mary Beth Terry, Ph.D., of Columbia University.

Quantifying the Genetic Correlation between Multiple Cancer Types

Lindström S, Finucane H, Bulik-Sullivan B, Schumacher FR, Amos CI, Hung RJ, Rand K, Gruber SB, Conti D, Permuth JB, Lin HY, Goode EL, Sellers TA, Amundadottir LT, Stolzenberg-Solomon R, Klein A, Petersen G, Risch H, Wolpin B, Hsu L, Huyghe JR, Chang-Claude J, Chan A, Berndt S, Eeles R, Easton D, Haiman CA, Hunter DJ, Neale B, Price AL, Kraft P; PanScan, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL-ILCCO. Quantifying the Genetic Correlation between Multiple Cancer Types. Cancer Epidemiol Biomarkers Prev. 2017 Sep;26(9):1427-1435.

This research was funded by EGRP grants to the following: Christopher I. Amos, Ph.D., of Dartmouth University; Steven Gallinger, M.D., M.S., F.R.C.S.C., of the University of Toronto, Cancer Care Ontario; Stephen B. Gruber, M.D., Ph.D., M.P.H., of the University of Southern California; Robert W. Haile, Ph.D., M.P.H., of Cedars-Sinai Medical Center; Christopher Alan Haiman,Sc.D., of the University of Southern California; Li Hsu, Ph.D., of the Fred Hutchinson Cancer Research Center; David John Hunter, M.B.B.S., M.P.H., Sc.D., of Harvard University; Alison P. Klein, Ph.D., of Johns Hopkins University; Laurence N. Kolonel, Ph.D., of the University of Hawaii at Manoa; Sara Lindstroem, Ph.D., M.S., of the University of Washington and Harvard University; Polly A. Newcomb, Ph.D., M.P.H., of the Fred Hutchinson Cancer Research Center; Shuji Ogino, M.D., Ph.D., M.S., of the Dana-Farber Cancer Institute; Ulrike Peters, Ph.D., M.P.H., of the Fred Hutchinson Cancer Research Center; Martha L. Slattery, Ph.D., M.P.H., of the University of Utah; Meir Jonathan Stampfer, M.D., Dr.P.H., of Brigham and Women’s Hospital; and Walter C. Willett, M.D., Dr.P.H., of Harvard University.


Survivorship

The Cumulative Burden of Surviving Childhood Cancer: An Initial Report from the St Jude Lifetime Cohort Study (SJLIFE)

Bhakta N, Liu Q, Ness KK, Baassiri M, Eissa H, Yeo F, Chemaitilly W, Ehrhardt MJ, Bass J, Bishop MW, Shelton K, Lu L, Huang S, Li Z, Caron E, Lanctot J, Howell C, Folse T, Joshi V, Green DM, Mulrooney DA, Armstrong GT, Krull KR, Brinkman TM, Khan RB, Srivastava DK, Hudson MM, Yasui Y, Robison LL. The Cumulative Burden of Surviving Childhood Cancer: An Initial Report from the St Jude Lifetime Cohort Study (SJLIFE). Lancet. 2017 Dec 9;390(10112):2569-2582.

This research was funded by an EGRP grant to Melissa M. Hudson, M.D., of St. Jude’s Children’s Research Hospital.

Return to Top