September 2018 Cancer Epidemiology Matters E-News
Cancer Epidemiology Matters E-News
- Funding Opportunity Announcement Promotes the Use of Modular R01s
- New NIH Initiative to Create Exposure Assessment Resources for Epidemiologic and Clinical Research
Funding Opportunity Announcement Promotes the Use of Modular R01s
Competition for research dollars continues to increase as a large amount of grant applications far outstrip the availability of NIH research funds. However, many important research questions may be addressed with more modest budgets, thus enabling more investigators to obtain funding.
The Division of Cancer Control and Populations Sciences (DCCPS) at the National Cancer Institute (NCI) released a funding opportunity announcement (FOA) to promote the use of modular R01s for research in cancer control and population sciences.
A modular R01 is not a new mechanism. Instead, it is an R01 that does not exceed $250,000 in direct costs in any years. Some other characteristics of a modular RO1:
- Modules are established in which direct costs are requested by budget period, without categorical breakdown of costs;
- Detailed budget justification is required for personnel; and
- Proposed research aims should be supported by strong preliminary research.
The goal of DCCPS’s PAR-18-869 (Modular R01s in Cancer Control and Population Sciences) is to advance cancer control research opportunities, especially for early-stage investigators (ESIs), and to increase the number of NIH-funded investigators. The FOA calls for research on a broad range of scientific areas within the division’s mission and portfolio. Areas of emphasis for this FOA include:
- Applied Informatics Methods for Cancer Surveillance
- Behavioral Research
- Cancer Survivorship
- Environmental Epidemiology
- Genomic Epidemiology
- Health Care Delivery Research
- Implementation Science
- Statistical and Analytic Methods
- Systems Modeling in Cancer Epidemiology
- Using Trends in Cancer Survival Estimates to Inform Cancer Control
All extramural investigators proposing research in the population sciences are encouraged to apply. Foreign and domestic institutions are eligible. New, renewal, resubmission, and revision application types are allowed. The next application due date is November 7, 2018. All applications will be reviewed in the Center for Scientific Review (CSR) standard study sections or corresponding member conflict panels using standard review criteria for R01s.
For more information about PAR-18-869, see the funding announcement or view the recorded webinar, "Modular R01s in Cancer Control and Population Sciences," from September 12, 2018, along with answers to frequently asked questions, which will be available in October at https://cancercontrol.cancer.gov/funding-foa-applicants.html.
New NIH Initiative to Create Exposure Assessment Resources for Epidemiologic and Clinical Research
NIH’s National Institute of Environmental Health Sciences (NIEHS) is establishing a new infrastructure, the Human Health Exposure Analysis Research (HHEAR), which will enable the research community to access laboratory and statistical analyses to add or expand the inclusion of multiple environmental exposures in existing studies involving research focused on understanding and improving human health.
The first step in establishing the HHEAR infrastructure was the issuance of five funding opportunity announcements (FOAs) in the NIH Guide for Grants and Contracts:
- Coordinating Center (RFA-ES-18-010)
- Data Repository, Analysis and Science Center (RFA-ES-18-014)
- Targeted Exposure Analysis Laboratories (RFA-ES-18-011)*
- Untargeted Exposure Analysis Laboratories (RFA-ES-18-012)*
- Environmental Exposure Analysis Laboratories (RFA-ES-18-013)
*NCI is participating in this FOA.
These five FOAs use the U2C, resource-related research multi-component projects and centers cooperative agreements, mechanism. Applications to the HHEAR FOAs are due October 29, 2018.
Exposures measured by HHEAR will cover the breadth of the exposome, including biological, psychosocial, chemical, and physical exposures. The environment is defined broadly and will include exposures associated with lifestyle and the social environment if they can be measured within the HHEAR infrastructure.
HHEAR, similar to the Center for Inherited Disease Research (CIDR) model for genotyping, builds on the success of NIEHS’ Children's Health Exposure Analysis Resource (CHEAR). The HHEAR initiative will continue the essential structure of CHEAR, which utilizes a consortium-based approach, consisting of a Coordinating Center, Data Center and Repository, and a network of analytical laboratories.
Once awards are made for the five HHEAR FOAs and the HHEAR Coordinating Center; Data Repository, Analysis and Science Center; and the three analysis laboratories are set up, more details will be shared with the research community about the process for utilizing this new resource.
The Epidemiology and Genomics Research Program of the National Cancer Institute (NCI) supports research in human populations to understand determinants of cancer occurrence and outcomes and is partnering with NIEHS in this initiative. This exciting new resource will allow investigators an opportunity to access laboratories that will assay biospecimens enabling the inclusion of new data to address the gaps in our understanding of how myriad environmental exposures influence cancer risk.