January 2019 Cancer Epidemiology Matters E-News

Cancer Epidemiology Matters E-News

January 2019

Announcing EGRP’s 2018 Research Highlights!

Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. EGRP asked NCI grantees with projects supported by current or recently-closed grants (i.e., grants that ended in 2017 or 2018) that are or were managed by EGRP to nominate one publication from 2018 that exemplifies the research from the grant.

Articles nominated by grantees were excluded if they did not contain research results or did not acknowledge the grant funding in the manuscript.

Below are the final selections for EGRP's 2018 Research Highlights, listed in alphabetical order by first author.


A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts

Ankerst DP, Straubinger J, Selig K, Guerrios L, De Hoedt A, Hernandez J, et al. A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts. Eur Urol. 2018 Aug;74(2):197-203.


Association of Analgesic Use with Risk of Ovarian Cancer in the Nurses' Health Studies

Barnard ME, Poole EM, Curhan GC, Eliassen AH, Rosner BA, Terry KL, et al. Association of Analgesic Use with Risk of Ovarian Cancer in the Nurses' Health Studies. JAMA Oncol. 2018 Dec 1;4(12):1675-1682.


Serologic Response to Helicobacter pylori Proteins Associated with Risk of Colorectal Cancer Among Diverse Populations in the United States

Butt J, Varga MG, Blot WJ, Teras L, Visvanathan K, Le Marchand L, et al. Serologic Response to Helicobacter pylori Proteins Associated with Risk of Colorectal Cancer Among Diverse Populations in the United States. Gastroenterology. 2019 Jan;156(1):175-186.e2.


Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma

Chen GM, Kannan L, Geistlinger L, Kofia V, Safikhani Z, Gendoo DMA, et al. Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma. Clin Cancer Res. 2018 Oct 15;24(20):5037-5047.


Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non-Small Cell Lung Cancer
Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer

Epplein M, Butt J, Zhang Y, Hendrix LH, Abnet CC, Murphy G, et al. Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer. Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1472-1479.


Human Pegivirus Infection and Lymphoma Risk and Prognosis: A North American Study

Fama A, Xiang J, Link BK, Allmer C, Klinzman D, Feldman AL, et al. Human Pegivirus Infection and Lymphoma Risk and Prognosis: A North American Study. Br J Haematol. 2018 Sep;182(5):644-653.


Drinking Alcohol Is Associated with Variation in the Human Oral Microbiome in a Large Study of American Adults

Fan X, Peters BA, Jacobs EJ, Gapstur SM, Purdue MP, Freedman ND, et al. Drinking Alcohol Is Associated with Variation in the Human Oral Microbiome in a Large Study of American Adults. Microbiome. 2018 Apr 24;6(1):59.


Fine Mapping of MHC Region in Lung Cancer Highlights Independent Susceptibility Loci by Ethnicity

Ferreiro-Iglesias A, Lesseur C, McKay J, Hung RJ, Han Y, Zong X, et al. Fine Mapping of MHC Region in Lung Cancer Highlights Independent Susceptibility Loci by Ethnicity. Nat Commun. 2018 Sep 25;9(1):3927.


Circulating Anti-Müllerian Hormone and Breast Cancer Risk: A Study in Ten Prospective Cohorts

Ge W, Clendenen TV, Afanasyeva Y, Koenig KL, Agnoli C, Brinton LA, et al. Circulating Anti-Müllerian Hormone and Breast Cancer Risk: A Study in Ten Prospective Cohorts. Int J Cancer. 2018 Jun 1;142(11):2215-2226.


Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study

Gigic B, Boeing H, Toth R, Böhm J, Habermann N, Scherer D, et al. Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study. Nutr Cancer. 2018 Jan;70(1):51-60.


Ultraspecific and Amplification-Free Quantification of Mutant DNA by Single-Molecule Kinetic Fingerprinting

Hayward SL, Lund PE, Kang Q, Johnson-Buck A, Tewari M, Walter NG. Ultraspecific and Amplification-Free Quantification of Mutant DNA by Single-Molecule Kinetic Fingerprinting. J Am Chem Soc. 2018 Sep 19;140(37):11755-11762.


Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study

Himbert C, Ose J, Nattenmüller J, Warby CA, Holowatyj AN, Böhm J, et al. Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study. Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):76-82.


On Estimation of the Hazard Function from Population-Based Case–Control Studies

Hsu L, Gorfine M, Zucker D. On Estimation of the Hazard Function from Population-Based Case–Control StudiesExternal Web Site Policy. J Am Stat Assoc. 2018;113:522, 560-570.


Discovery of Common and Rare Genetic Risk Variants for Colorectal Cancer

Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S, Schmit SL, et al. Discovery of Common and Rare Genetic Risk Variants for Colorectal Cancer. Nat Genet. 2019 Jan;51(1):76-87.


Microbiome and Bile Acid Profiles in Duodenal Aspirates from Patients with Liver Cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study

Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, et al. Microbiome and Bile Acid Profiles in Duodenal Aspirates from Patients with Liver Cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study. Hepatol Res. 2018 Dec;48(13):1108-1117


Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors

Jeon J, Du M, Schoen RE, Hoffmeister M, Newcomb PA, Berndt SI, et al. Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors. Gastroenterology. 2018 Jun;154(8):2152-2164.e19.


Association of Leisure-Time Physical Activity with Total and Cause-Specific Mortality: A Pooled Analysis of Nearly a Half Million Adults in the Asia Cohort Consortium
Large-scale Genome-wide Association Study of East Asians Identifies Loci Associated with Risk for Colorectal Cancer

Lu Y, Kweon SS, Tanikawa C, Jia WH, Xiang YB, Cai Q, et al. Large-scale Genome-wide Association Study of East Asians Identifies Loci Associated with Risk for Colorectal Cancer. Gastroenterology. 2018 Dec 6. pii: S0016-5085(18)35385-X. doi: 10.1053/j.gastro.2018.11.066. Epub ahead of print.


Association of Coffee and Tea Intake with the Oral Microbiome: Results from a Large Cross-Sectional Study

Peters BA, McCullough ML, Purdue MP, Freedman ND, Um CY, Gapstur SM, et al. Association of Coffee and Tea Intake with the Oral Microbiome: Results from a Large Cross-Sectional Study. Cancer Epidemiol Biomarkers Prev. 2018 Jul;27(7):814-821.


Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort

Setiawan VW, Stram DO, Porcel J, Chari ST, Maskarinec G, Le Marchand L, et al. Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort. J Natl Cancer Inst. 2018 Jun 18.


Association Between Aspirin Use and Risk of Hepatocellular Carcinoma

Simon TG, Ma Y, Ludvigsson JF, Chong DQ, Giovannucci EL, Fuchs CS, et al. Association Between Aspirin Use and Risk of Hepatocellular Carcinoma. JAMA Oncol. 2018 Dec 1;4(12):1683-1690.


A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics

Su YR, Di C, Bien S, Huang L, Dong X, Abecasis G, et al. A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics. Am J Hum Genet. 2018 May 3;102(5):904-919.


Utility of TERT Promoter Mutations for Cutaneous Primary Melanoma Diagnosis

Thomas NE, Edmiston SN, Tsai YS, Parker JS, Googe PB, Busam KJ, et al. Utility of TERT Promoter Mutations for Cutaneous Primary Melanoma Diagnosis. Am J Dermatopathol. 2018 Sep 11.


A Prediction Tool to Facilitate Risk-Stratified Screening for Squamous Cell Skin Cancer

Wang W, Jorgenson E, Ioannidis NM, Asgari MM, Whittemore AS. A Prediction Tool to Facilitate Risk-Stratified Screening for Squamous Cell Skin Cancer. J Invest Dermatol. 2018 Dec;138(12):2589-2594.


Prognostic Modeling of the Immune-Centric Transcriptome Reveals Interleukin Signaling Candidates Contributing to Differential Patient Outcomes

Watza D, Lusk CM, Dyson G, Purrington KS, Chen K, Wenzlaff AS, et al. Prognostic Modeling of the Immune-Centric Transcriptome Reveals Interleukin Signaling Candidates Contributing to Differential Patient Outcomes. Carcinogenesis. 2018 Dec 31;39(12):1447-1454.


Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, et al. Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res. 2018 May 15;78(10):2747-2759.


A Transcriptome-Wide Association Study of 229,000 Women Identifies New Candidate Susceptibility Genes for Breast Cancer

Wu L, Shi W, Long J, Guo X, Michailidou K, Beesley J, et al. A Transcriptome-Wide Association Study of 229,000 Women Identifies New Candidate Susceptibility Genes for Breast Cancer. Nat Genet. 2018 Jul;50(7):968-978.


Overall and Central Obesity and Risk of Lung Cancer: A Pooled Analysis

Yu D, Zheng W, Johansson M, Lan Q, Park Y, White E, et al. Overall and Central Obesity and Risk of Lung Cancer: A Pooled Analysis. J Natl Cancer Inst. 2018 Aug 1;110(8):831-842.


Leukocyte Telomere Length in Relation to Risk of Lung Adenocarcinoma Incidence: Findings from the Singapore Chinese Health Study

Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, et al. Leukocyte Telomere Length in Relation to Risk of Lung Adenocarcinoma Incidence: Findings from the Singapore Chinese Health Study. Int J Cancer. 2018 Jun 1;142(11):2234-2243.


Serum Nitrogen and Carbon Stable Isotope Ratios Meet Biomarker Criteria for Fish and Animal Protein Intake in a Controlled Feeding Study of a Women's Health Initiative Cohort

Yun HY, Lampe JW, Tinker LF, Neuhouser ML, Beresford SAA, Niles KR, et al. Serum Nitrogen and Carbon Stable Isotope Ratios Meet Biomarker Criteria for Fish and Animal Protein Intake in a Controlled Feeding Study of a Women's Health Initiative Cohort. J Nutr. 2018 Dec 1;148(12):1931-1937.


Lifestyle Factors and Health-Related Quality of Life in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study

Zhang FF, Hudson MM, Huang IC, Bhakta N, Ness KK, Brinkman TM, et al. Lifestyle Factors and Health-Related Quality of Life in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study. Cancer. 2018 Oct 1;124(19):3918-3923. Epub 2018 Sep 11.


High-Throughput Screening of Prostate Cancer Risk Loci by Single Nucleotide Polymorphisms Sequencing

Zhang P, Xia JH, Zhu J, Gao P, Tian YJ, Du M, et al. High-Throughput Screening of Prostate Cancer Risk Loci by Single Nucleotide Polymorphisms Sequencing. Nat Commun. 2018 May 22;9(1):2022.


EGRP funds research in human populations to understand determinants of cancer occurrence and outcomes. The Program is the largest funder of cancer epidemiology grants nationally and worldwide, awarding more than 240 grants and cooperative agreements annually. View a full list of active EGRP grants.

Funding Opportunities

  • U.S.-China Program for Biomedical Collaborative Research (R01 - Clinical Trial Optional)
  • Improving Outcomes for Pediatric, Adolescent and Young Adult Cancer Survivors (U01 - Clinical Trial Required, Pre-Application Webinar on Jan. 31, 2019)
  • Provocative Questions in Cancer with an Underlying HIV Infection (R01 Clinical Trial Optional)
  • Notice of Intent to Publish a Funding Opportunity Announcement for Administrative Supplements for Research on Bioethical Issues (NOT-OD-19-045)

Grants Policy Announcements

  • NIH Implementation of the Final Rule on the Federal Policy for the Protection of Human Subjects (Common Rule) (NOT-OD-19-050)
  • NIH Policy for Review and Resubmission of New Investigator R01 Applications (NOT-OD-19-053)
  • Removal of the Requirement for Institutional Review Board Review of NIH Grant Applications and Contract Proposals Related to Research (NOT-OD-19-055)
  • Notice of Clarification Regarding Harassment and Discrimination Protections in NIH Training Applications (NOT-OD-19-056)

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