May 2019 Cancer Epidemiology Matters E-News

Cancer Epidemiology Matters E-News

May 2019

Cancer and Accelerated Aging: Advancing Research for Healthier Survivors

The Epidemiology and Genomics Research Program (EGRP) and Behavioral Research Program (BRP) at the National Cancer Institute (NCI) have conducted two workshops aimed at identifying knowledge gaps related to understanding, predicting, and mitigating short- and long-term aging-related consequences of cancer and cancer treatments, and generating information needed to fill those gaps.

As of January 2019, there were an estimated 16.9 million cancer survivors in the United States, 64% of whom were 65 years of age or older. It is projected that the number of cancer survivors will grow to 26.1 million by 2040. While newer and better cancer treatments have been effective in decreasing cancer-related mortality, they often place survivors at risk for experiencing a broad spectrum of aging-related health conditions, such as frailty and sarcopenia, earlier in life than would be expected during the normal aging process or aging-related problems above and beyond what might occur in the absence of cancer treatment.

Two think tank meetings were held, one in 2018 and one in 2019, to bring together staff from NCI and the National Institute on Aging (NIA) and extramural researchers to discuss the state of the science in this area and provide recommendations for moving the field forward. The July 2018 meeting, “Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors,” focused on identifying the best methods (molecular and clinical) to measure aging among cancer survivors. The February 2019 meeting, “Strategies to Prevent or Remediate Cancer- and Treatment-Associated Aging,” examined current and needed strategies to prevent, reverse, or slow the progression of treatment-associated accelerated aging trajectories among cancer survivors.

Other ongoing or planned efforts related to cancer and accelerated aging include developing a webinar series focused on cancer, cancer treatment, and aging and creating a list of resources that investigators can use for cancer survivorship research on aging outcomes.

For more information on these activities, visit the Aging Trajectories in Cancer Survivors web page or contact EGRP Program Director Lisa Gallicchio, Ph.D.

Recent NCI Funding Opportunities

  • Exploratory Grants in Cancer Epidemiology (R21 - Clinical Trial Optional)
  • Provocative Questions (PQs) in Multiple Myeloma Disparities Research (R01, R21 - Clinical Trial Optional)
  • HLA and KIR Region Genomics in Immune-Mediated Diseases (U01 - Clinical Trial Not Allowed)
  • Clinical and Epidemiological Research on Chronic Disease in the Caribbean (R01 - Clinical Trial Not Allowed)
  • Dissemination and Implementation Research in Health (R01, R21 - Clinical Trial Optional; R03 - Clinical Trial Not Allowed)

Funding Opportunities from Other NIH Institutes

  • Notice of Special Interest for Small Business Research in Genomics (R43/R44)
  • The Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network – Clinical Sites (U01 - Clinical Trial Required)

Requests for Information

  • Request for Information: Research Plan on Rehabilitation (NOT-HD-19-006)

Recent Training Opportunities

New Research Resources

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