January 2020 Cancer Epidemiology Matters E-News

Cancer Epidemiology Matters E-News


Announcing EGRP’s 2019 Research Highlights!

Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. EGRP asked NCI grantees with projects supported by current or recently-closed grants (i.e., grants that ended in 2018 or 2019) that are or were assigned to EGRP. Submitted articles also had to include an acknowledgement of the grant funding.

Below are the final selections for EGRP's 2019 Research Highlights, listed in alphabetical order by first author. The star icon * indicates publications where the data have been deposited in a controlled-access or publicly accessible data repository (e.g., dbGaP).

* PIXUL-ChIP: Integrated High-Throughput Sample Preparation and Analytical Platform for Epigenetic Studies

Bomsztyk K, Mar D, Wang Y, Denisenko O, Ware C, Frazar CD, et al. PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studies. Nucleic Acids Res. 2019;47(12):e69.

* Multi-Region Exome Sequencing Reveals Genomic Evolution from Preneoplasia to Lung Adenocarcinoma

Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, et al. Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma. Nat Commun. 2019;10(1):2978.

* Discovery of Common and Rare Genetic Risk Variants for Colorectal Cancer

Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S, Schmit SL, et al. Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2019 Jan 1;51(1):76–87.

* Structured Gene-Environment Interaction Analysis

Wu M, Zhang Q, Ma S. Structured gene-environment interaction analysis. Biometrics. 2019 Aug 19.

* MOWChIP-seq for Low-Input and Multiplexed Profiling of Genome-Wide Histone Modifications

Zhu B, Hsieh Y-P, Murphy TW, Zhang Q, Naler LB, Lu C. MOWChIP-seq for low-input and multiplexed profiling of genome-wide histone modifications. Nat Protoc. 2019 Dec;14(12):3366–94.

Housing Discrimination and Racial Cancer Disparities Among the 100 Largest U.S. Metropolitan Areas

Beyer KMM, Laud PW, Zhou Y, Nattinger AB. Housing discrimination and racial cancer disparities among the 100 largest US metropolitan areas. Cancer. 2019 Nov 1;125(21):3818–27.

Smoking, Helicobacter pylori Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea.

Butt J, Varga MG, Wang T, Tsugane S, Shimazu T, Zheng W, et al. Smoking, Helicobacter pylori serology, and gastric cancer risk in prospective studies from China, Japan, and Korea. Cancer Prev Res (Phila). 2019 Oct;12(10):667–74.

Re-interpretation of PAM50 Gene Expression as Quantitative Tumor Dimensions Shows Utility for Clinical Trials: Application to Prognosis and Response to Paclitaxel in Breast Cancer

Camp NJ, Madsen MJ, Herranz J, Rodríguez-Lescure Á, Ruiz A, Martín M, et al. Re-interpretation of PAM50 gene expression as quantitative tumor dimensions shows utility for clinical trials: application to prognosis and response to paclitaxel in breast cancer. Breast Cancer Res Treat. 2019 May;175(1):129–39.

Classification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network

Carter RE, Attia ZI, Geske JR, Conners AL, Whaley DH, Hunt KN, et al. Classification of background parenchymal uptake on molecular breast imaging using a convolutional neural network. JCO Clin Cancer Informatics. 2019 Feb;(3):1–11.

Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers

Chen Z, Wen W, Beeghly-Fadiel A, Shu X ou, Díez-Obrero V, Long J, et al. Identifying putative susceptibility genes and evaluating their associations with somatic mutations in human cancers. Am J Hum Genet. 2019 Sep 5;105(3):477–92.

Associations of Tobacco and Alcohol Use with Risk of Neuroendocrine Tumors of the Small Intestine in Utah

Curtin K, Cannon-Albright LA, VanDerslice J, Yu Z, Herget KA, Thota R, et al. Associations of tobacco and alcohol use with risk of neuroendocrine tumors of the small intestine in Utah. Cancer Epidemiol Biomarkers Prev. 2019 Sep 26;cebp.0465.2019.

Associations of Dairy Intake with Risk of Mortality in Women and Men: Three Prospective Cohort Studies

Ding M, Li J, Qi L, Ellervik C, Zhang X, Manson JE, et al. Associations of dairy intake with risk of mortality in women and men: three prospective cohort studiesExternal Web Site Policy. BMJ. 2019;367.

Elevated IgM and Abnormal Free Light Chain Ratio are Increased in Relatives from High-Risk Chronic Lymphocytic Leukemia Pedigrees

Glenn MJ, Madsen MJ, Davis E, Garner CD, Curtin K, Jones B, et al. Elevated IgM and abnormal free light chain ratio are increased in relatives from high-risk chronic lymphocytic leukemia pedigrees. Blood Cancer J. 2019;9(3):25.

Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology

Grigoryan H, Schiffman C, Gunter MJ, Naccarati A, Polidoro S, Dagnino S, et al. Cys34 adductomics links colorectal cancer with the gut microbiota and redox biology. Cancer Res. 2019 Oct 22;canres.1529.2019.

Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer

Haffa M, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, et al. Transcriptome profiling of adipose tissue reveals depot-specific metabolic alterations among patients with colorectal cancer. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5225–37.

Financial Hardship and Quality of Life Among African American and White Cancer Survivors: The Role of Limiting Care Due to Cost

Hastert TA, Kyko JM, Reed AR, Harper FWK, Beebe-Dimmer JL, Baird TE, et al. Financial hardship and quality of life among African American and white cancer survivors: the role of limiting care due to cost. Cancer Epidemiol Biomarkers Prev. 2019;28(7):1202–11.

Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multi-omics Analysis

Holowatyj AN, Gigic B, Herpel E, Scalbert A, Schneider M, Ulrich CM, et al. Distinct molecular phenotype of sporadic colorectal cancers among young patients based on multi-omics analysis. Gastroenterology. 2019 Nov 12.

Interethnic Differences in Pancreatic Cancer Incidence and Risk Factors: The Multiethnic Cohort

Huang BZ, Stram DO, Le Marchand L, Haiman CA, Wilkens LR, Pandol SJ, et al. Interethnic differences in pancreatic cancer incidence and risk factors: the Multiethnic Cohort. Cancer Med. 2019 Jul 1;8(7):3592–603.

Shared Heritability and Functional Enrichment Across Six Solid Cancers

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019 Dec 1;10(1).

A Guide to Nucleic Acid Detection by Single-Molecule Kinetic Fingerprinting

Johnson-Buck A, Li J, Tewari M, Walter NG. A guide to nucleic acid detection by single-molecule kinetic fingerprinting. Methods. 2019;153:3–12.

Changes in CT Radiomic Features Associated with Lymphocyte Distribution Predict Overall Survival and Response to Immunotherapy in Non-Small Cell Lung Cancer

Khorrami M, Prasanna P, Gupta A, Patil P, Velu PD, Thawani R, et al. Changes in CT radiomic features associated with lymphocyte distribution predict overall survival and response to immunotherapy in non-small cell lung cancer. Cancer Immunol Res. 2019 Nov 12.

Racial/Ethnic Differences in Survival Among Gastric Cancer Patients in California.

Klapheke AK, Carvajal-Carmona LG, Cress RD. Racial/ethnic differences in survival among gastric cancer patients in California. Cancer Causes Control. 2019 Jul;30(7):687–96.

Inherited Variants at 3q13.33 and 3p24.1 are Associated with Risk of Diffuse Large B-cell Lymphoma and Implicate Immune Pathways

Kleinstern G, Yan H, Hildebrandt MAT, Vijai J, Berndt SI, Ghesquières H, et al. Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways. Hum Mol Genet. 2019 Oct 10.

Genetic Testing and Results in a Population-Based Cohort of Breast Cancer Patients and Ovarian Cancer Patients

Kurian AW, Ward KC, Howlader N, Deapen D, Hamilton AS, Mariotto A, et al. Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients. J Clin Oncol. 2019 May 20;37(15):1305–15.

Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective U.S. Cohort Studies

Lee DH, Fung TT, Tabung FK, Colditz GA, Ghobrial IM, Rosner BA, et al. Dietary pattern and risk of multiple myeloma in two large prospective US cohort studies. JNCI Cancer Spectr. 2019 Jun 1;3(2).

Fatty Acid Composition in Mammary Adipose Tissue Measured by Gradient-echo Spectroscopic MRI and its Association with Breast Cancers

Lewin AA, Storey P, Moccaldi M, Moy L, Gene Kim S. Fatty acid composition in mammary adipose tissue measured by Gradient-echo Spectroscopic MRI and its association with breast cancers. Eur J Radiol. 2019 Jul;116:205–11.

Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes

Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, et al. Identification of cancer drivers at CTCF insulators in 1,962 whole genomes. Cell Syst. 2019 May 22;8(5):446-455.e8.

A Prospective Study of Toenail Trace Element Levels and Risk of Skin Cancer

Matthews NH, Koh M, Li W-Q, Li T, Willett WC, Stampfer MJ, et al. A prospective study of toenail trace element levels and risk of skin cancer. Cancer Epidemiol Biomarkers Prev. 2019 Sep;28(9):1534–43.

Diet Associations with Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort

Noureddin M, Zelber-Sagi S, Wilkens LR, Porcel J, Boushey CJ, Le Marchand L, et al. Diet associations with nonalcoholic fatty liver disease in an ethnically diverse population: the Multiethnic Cohort. Hepatology. 2019 Sep 25.

Fortification of Bakery and Corn Masa-Based Foods in Mexico and Dietary Intake of Folic Acid and Folate in Mexican National Survey Data

Orjuela MA, Mejia-Rodriguez F, Quezada AD, Sanchez-Pimienta TG, Shamah-Levy T, Romero-Rendón J, et al. Fortification of bakery and corn masa–based foods in Mexico and dietary intake of folic acid and folate in Mexican national survey data. Am J Clin Nutr. 2019 Sep 16.

Cause of Death in Follicular Lymphoma in the First Decade of the Rituximab Era: A Pooled Analysis of French and U.S. Cohorts

Sarkozy C, Maurer MJ, Link BK, Ghesquieres H, Nicolas E, Thompson CA, et al. Cause of death in follicular lymphoma in the first decade of the rituximab era: a pooled analysis of French and US cohorts. J Clin Oncol. 2019;37(2):144–52.

Radio-Biologically Motivated Modeling of Radiation Risks of Mortality from Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study

Schöllnberger H, Kaiser JC, Eidemüller M, Zablotska LB. Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study. Radiat Environ Biophys. 2019 Nov 28.

10-year Performance of Four Models of Breast Cancer Risk: A Validation Study

Terry MB, Liao Y, Whittemore AS, Leoce N, Buchsbaum R, Zeinomar N, et al. 10-year performance of four models of breast cancer risk: a validation study. Lancet Oncol. 2019 Apr 1;20(4):504–17.

Combined Effect of Modifiable and Non-Modifiable Risk Factors for Colorectal Cancer Risk in a Pooled Analysis of 11 Population-Based Studies

Wang X, O’Connell K, Jeon J, Song M, Hunter D, Hoffmeister M, et al. Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies. BMJ open Gastroenterol. 2019;6(1):e000339.

COPD-dependent Effects of Genetic Variation in Key Inflammation Pathway Genes on Lung Cancer Risk

Watza D, Lusk CM, Dyson G, Purrington KS, Wenzlaff AS, Neslund-Dudas C, et al. COPD-dependent effects of genetic variation in key inflammation pathway genes on lung cancer risk. Int J Cancer. 2019 Nov 10.

Late Mortality After Bone Marrow Transplant for Chronic Myelogenous Leukemia in the Context of Prior Tyrosine Kinase Inhibitor Exposure: A Blood or Marrow Transplant Survivor Study (BMTSS) Report

Association of Dietary Fiber and Yogurt Consumption with Lung Cancer Risk: A Pooled Analysis

Yang JJ, Yu D, Xiang Y-B, Blot W, White E, Robien K, et al. Association of dietary fiber and yogurt consumption with lung cancer risk: a pooled analysis. JAMA Oncol. 2019 Oct 24.

Single-nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at Prostate Cancer Risk Loci

Zhang P, Tillmans LS, Thibodeau SN, Wang L. Single-nucleotide polymorphisms sequencing identifies candidate functional variants at prostate cancer risk loci. Genes (Basel). 2019 Jul 1;10(7).

Funding Opportunities

  • Research Answers to National Cancer Institute's (NCI) Provocative Questions (R01 & R21, Clinical Trial Optional)
  • Mechanisms of Disparities in Chronic Liver Diseases and Cancer (R01 & R21, Clinical Trial Not Allowed)
  • Biomedical Data Repository (U24, Clinical Trials Not Allowed)
  • Biomedical Knowledgebase (U24, Clinical Trials Not Allowed)
  • Methods and Measurement in Research with Sexual and Gender Minority (SGM) Populations (R21, Clinical Trials Not Allowed)
  • Notice of Special Interest (NOSI): Development of Statistical, Population Genetics and Computational Methods Related to Polygenic Prediction of Health and Disease in Diverse Populations (NOT-HG-20-010)
  • Genomic Expert Curation Panels (U24, Clinical Trial Not Allowed)
  • NOSI: Administrative Supplement for Research on Bioethical Issues (Admin Supp Clinical Trial Optional) (NOT-OD-20-038)
  • NOSI: Administrative Supplements to Promote Research Continuity and Retention of NIH Mentored Career Development (K) Award Recipients and Scholars (NOT-OD-20-054)
  • NOSI: Alzheimer’s-focused Administrative Supplements for NIH/NCI Grants that are not focused on Alzheimer’s Disease (NOT-AG-20-008)
  • NOSI: Use of Biological "High" or "Medium" Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (NOT-CA-20-022)

Grants Policy Notices

  • NCI Full Year Funding Policy for RPG Awards FY2020
  • OMB Approval for Grant Application and Related Forms Underway – Continue to Use Current Forms (FORMS-E) through May 24, 2020 (NOT-OD-20-047)
  • UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding (NOT-OD-20-018)
  • Additional Guidance on the NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research (NOT-OD-20-058)
  • Update of NIH Continuous Submission Policy: Change in Submission Deadlines and End of Recent Substantial Service Option (NOT-OD-20-060)

Request for Information

  • Request for Information (RFI) Seeking Stakeholder Input on Scientific Gaps and Research Needs to Address Associations Between Environmental Exposures and Cancer Risk (NOT-CA-20-024)

Research Resources

  • NCI-funded investigators may apply to use the Human Health Exposure Analysis Resource to integrate environmental exposures into existing studies. Applications accepted Jan 31-Feb 28, 2020. View a recent webinar about HHEARExternal Web Site Policy.
  • Notice of Information: National Death Index Linkage Access for NIH-Supported Investigators (NOT-OD-20-057)

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