May 2021 EGRP Cancer Epidemiology News

EGRP Cancer Epidemiology News

Six Challenges Announced for Critical Assessment of Genome Interpretation (CAGI)

Genomic variation is responsible for numerous rare diseases, including cancer. Genomic data, therefore, hold the promise of revolutionizing our understanding and treatment of human disease.

The Critical Assessment of Genome Interpretation (CAGI)External Web Site Policy conducts community experiments (or a set of challenges) to objectively assess computational methods for determining the phenotypic impacts of genomic variation. The primary goals are to establish the state of the art, to show where future progress may best be made, to highlight innovations and progress, and to build a strong collaborative community. In the CAGI challenges, participants are provided genetic variants and make predictions of resulting phenotypes. The experiment culminates in the CAGI ConferenceExternal Web Site Policy with publicationsExternal Web Site Policy in a special journal issue. CAGI has completed five editions between 2010-2018.

The sixth edition of CAGI challenges (also known as CAGI6) will be taking place over the Summer of 2021. The following challenge is now open:

  1. MTHFRExternal Web Site Policy - Predict effects of missense variants and their A222V dependence for methylenetetrahydrofolate reductase (closes on June 3, 2021)

The following challenges have been announced and will be released on June 1, 2021 (and additional challenges will be released soon):

  1. CalmodulinExternal Web Site Policy - Predicting the effects of disease-associated variants on the stability of calmodulin (closes on September 6, 2021)
  2. HMBSExternal Web Site Policy - Predict missense variant effects on hydroxymethylbilane synthase as measured by yeast complementation assay (closes on August 31, 2021)
  3. Annotate All MissenseExternal Web Site Policy - Predict pathogenicity of all nonsynonymous variants in the genome (closes on August 31, 2021)
  4. Rare Genomes ProjectExternal Web Site Policy - Identify diagnostic variants in children with rare disease from the Rare Genomes Project (closes on August 31, 2021)
  5. Intellectual Disability PanelExternal Web Site Policy - Predict patients’ clinical descriptions and pathogenic variants from gene panel sequences (closes on August 31, 2021)

Researchers from all backgrounds are welcome to participate in the challenges. To learn more, visit the CAGI websiteExternal Web Site Policy.

Also, the success of CAGI hinges on the generous contribution of pre-publication datasets. Contributors are, in turn, acknowledged for their involvement. To contact CAGI’s organizers, email

The CAGI experiment is supported by the National Institutes of Health (NIH) award U24 HG007346.

Funding Opportunity Announcements and Notices of Special Interest

  • Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) in Cancer Survivors Consortium (U01, Clinical Trial Required) and Coordinating Center for ENICTO in Cancer Survivors Consortium (U24, Clinical Trial Not Allowed)
    • Note: There will be a pre-application webinar for these RFAs on May 26, 2021 from 12:00 – 1:00 PM ET. View NOT-CA-21-078 for more details.
  • NIH Directors Early Independence Awards (DP5, Clinical Trials Optional)
  • Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors (R01 & R21, Clinical Trial Optional)
  • Data Generation Projects for the NIH Bridge to Artificial Intelligence (Bridge2AI) Program (OT2)
  • Notice of Special Interest (NOSI): Early-life Factors and Cancer Development Later in Life (NOT-CA-21-074)
  • NOSI: Public Policy Effects on Alcohol-, Cannabis-, Tobacco-, and Other Drug-Related Behaviors and Outcomes (NOT-AA-21-028)
  • NOSI: Developing and Testing Multilevel Physical Activity Interventions to Improve Health and Well-Being (NOT-OD-21-087)
    • Note: There will be a technical assistance webinar for this NOSI on June 8, 2021 from 10:00 – 11:30 AM ET. View NOT-OD-21-120 for more details.

Requests for Information

  • Enhancing the Science for the Environmental Influences on Child Health Outcomes (ECHO) Program (NOT-OD-21-108) (responses due May 25, 2021)
  • Response to Proposed NIH Sleep Disorders Research Plan Critical Opportunities and Strategic Goals (NOT-HL-21-011) (responses due May 31, 2021)
  • Seeking Stakeholder Input on Enhancing Cancer Health Disparities Research (NOT-CA-21-066) (responses due June 25, 2021)
  • Seeking Stakeholder Input on Enhancing Diversity and Inclusion in the Cancer Research Workforce (NOT-CA-21-067) (responses due July 15, 2021)

Grants Policy Notices

  • Implementation of Changes to the Biographical Sketch and Other Support Format Page (NOT-OD-21-110)
  • Announcing New Inbox for Inquiries Related to Changes to Biographical Sketch and Other Support Format Page (NOT-OD-21-122)

Job Opportunities

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