February 2022 EGRP Cancer Epidemiology News

EGRP Cancer Epidemiology News


Announcing EGRP’s 2021 Research Highlights!

Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. EGRP asked NCI grantees with projects supported by current or recently closed grants (i.e., grants that ended in 2020 or 2021) administered by EGRP to select and submit a research publication resulting from the grant. Submitted articles had to include an acknowledgement of the grant funding and comply with all NIH data sharing policies.

Below are the final selections for EGRP's 2021 Research Highlights, listed in alphabetical order by first author. The star icon * is for publications that noted that data have been deposited in a controlled-access or publicly accessible data repository (e.g., dbGaP).

Individual- and neighborhood-level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California

Nongenetic determinants of risk for early-onset colorectal cancer

Archambault AN, Lin Y, Jeon J, et al. Nongenetic determinants of risk for early-onset colorectal cancer. JNCI Cancer Spectr. 2021;5(3):pkab029.

Predicted vitamin D status and colorectal cancer incidence in the Black Women’s Health Study

Barber LE, Bertrand K, Petrick JL, et al. Predicted vitamin D status and colorectal cancer incidence in the Black Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2021;30(12):2334-2341.

The impact of the COVID-19 pandemic on African American cancer survivors

Beebe-Dimmer JL, Lusk CM, Ruterbusch JJ, et al. The impact of the COVID-19 pandemic on African American cancer survivors. Cancer. 2021;10.1002/cncr.33987.

Mortgage lending bias and breast cancer survival among older women in the United States

Beyer KMM, Zhou Y, Laud PW, et al. Mortgage lending bias and breast cancer survival among older women in the United States. J Clin Oncol. 2021;39(25):2749-2757.

Can cost-effectiveness analysis inform genotype-guided aspirin use for primary colorectal cancer prevention?

Biltaji E, Walker B, Au TH, et al. Can cost-effectiveness analysis inform genotype-guided aspirin use for primary colorectal cancer prevention? Cancer Epidemiol Biomarkers Prev. 2021;30(6):1106-1113.

Association of Fusobacterium Nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment

Borowsky J, Haruki K, Lau MC, et al. Association of Fusobacterium Nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment. Clin Cancer Res. 2021;27(10):2816-2826.

Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals

Chen H, Majumdar A, Wang L, et al. Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals. HGG Adv. 2021;2(3):100041.

Discovery of structural deletions in breast cancer predisposition genes using whole genome sequencing data from > 2000 women of African-ancestry

Associations of depressive symptoms with all-cause and cause-specific mortality by race in a population of low socioeconomic status: a report from the Southern Community Cohort Study

Disease-associated risk variants in ANRIL are associated with tumor-infiltrating lymphocyte presence in primary melanomas in the population-based GEM Study

Incidence of lung cancer among never-smoking Asian American, Native Hawaiian, and Pacific Islander females

DeRouen MC, Canchola AJ, Thompson CA, et al. Incidence of lung cancer among never-smoking Asian American, Native Hawaiian, and Pacific Islander females. J Natl Cancer Inst. 2022;114(1):78-86.

Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Graff RE, Cavazos TB, Thai KK, et al. Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts. Nat Commun. 2021;12(1):970.

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects

Clinical characteristics and outcomes of colorectal cancer in the ColoCare Study: differences by age of onset

Himbert C, Figueiredo JC, Shibata D, et al. Clinical characteristics and outcomes of colorectal cancer in the ColoCare Study: differences by age of onset. Cancers (Basel). 2021;13(15):3817.

Assessing lung cancer absolute risk trajectory based on a polygenic risk model

Hung RJ, Warkentin MT, Brhane Y, et al. Assessing lung cancer absolute risk trajectory based on a polygenic risk model. Cancer Res. 2021;81(6):1607-1615.

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia

Kachuri L, Jeon S, DeWan AT, et al. Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia. Am J Hum Genet. 2021;108(10):1823-1835.

Impact of organ function-based clinical trial eligibility criteria in patients with diffuse large B-cell lymphoma: who gets left behind?

Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma

Koyuncu CF, Lu C, Bera K, et al. Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma. J Clin Invest. 2021;131(8):e145488.

Time trends in receipt of germline genetic testing and results for women diagnosed with breast cancer or ovarian cancer, 2012-2019

Joint temporal dietary and physical activity patterns: associations with health status indicators and chronic diseases

CNCDatabase: a database of non-coding cancer drivers

Liu EM, Martinez-Fundichely A, Bollapragada R, Spiewack M, Khurana E. CNCDatabase: a database of non-coding cancer drivers. Nucleic Acids Res. 2021;49(D1):D1094-D1101.

A method for subtype analysis with somatic mutations

Liu M, Liu Y, Wu MC, Hsu L, He Q. A method for subtype analysis with somatic mutations. [published online ahead of print Jan 8, 2021]. Bioinformatics. 2021;btaa1090.

Rare deleterious germline variants and risk of lung cancer

Liu Y, Xia J, McKay J, et al. Rare deleterious germline variants and risk of lung cancer. NPJ Precis Oncol. 2021;5(1):12.

Interactions of age and blood immune factors and noninvasive prediction of glioma survival

Molinaro AM, Wiencke JK, Warrier G, et al. Interactions of age and blood immune factors and non-invasive prediction of glioma survival. [published online ahead of print Oct 1, 2021]. J Natl Cancer Inst. 2021;djab195.

Novel application of nutritional biomarkers from a controlled feeding study and an observational study to characterization of dietary patterns in postmenopausal women

A validated risk prediction model for breast cancer in U.S. Black women

Palmer JR, Zirpoli G, Bertrand KA, et al. A validated risk prediction model for breast cancer in U.S. Black women. J Clin Oncol. 2021;39(34):3866-3877.

Child serum metabolome and traffic-related air pollution exposure in pregnancy

Ritz B, Yan Q, He D, et al. Child serum metabolome and traffic-related air pollution exposure in pregnancy. Environ Res. Jan 2022;(203):111907.

Genetic variants associated with therapy-related cardiomyopathy among childhood cancer survivors of African ancestry

Functional genomic analyses of the 21q22.3 locus identifying functional variants and candidate gene YBEY for breast cancer risk

Delirium in children undergoing hematopoietic cell transplantation: a multi-institutional point prevalence study

Smoking and incidence of colorectal cancer subclassified by tumor-associated macrophage infiltrates

Ugai T, Väyrynen JP, Haruki K, et al. Smoking and incidence of colorectal cancer subclassified by tumor-associated macrophage infiltrates. J Natl Cancer Inst. 2022;114(1):68-77.

Association between smoking and molecular subtypes of colorectal cancer

Wang X, Amitay E, Harrison TA, et al. Association between smoking and molecular subtypes of colorectal cancer. JNCI Cancer Spectr. 2021;5(4):pkab056.

Multidimensional molecular measurements-environment interaction analysis for disease outcomes

Reduction in total and major cause-specific mortality from tobacco smoking cessation: a pooled analysis of 16 population-based cohort studies in Asia

Epigenetic alterations in keratinocyte carcinoma

Yao Q, Epstein CB, Banskota S, et al. Epigenetic alterations in keratinocyte carcinoma. J Invest Dermatol. 2021;141(5):1207-1218.

Multi-omics analysis to identify susceptibility genes for colorectal cancer

Yuan Y, Bao J, Chen Z, et al. Multi-omics analysis to identify susceptibility genes for colorectal cancer. Hum Mol Genet. 2021;30(5):321-330.

Risk projection for time-to-event outcome leveraging summary statistics with source individual-level data

Zheng J, Zheng Y, Hsu L. Risk projection for time-to-event outcome leveraging summary statistics with source individual-level dataExternal Web Site Policy. [published online ahead of print Apr 22, 2021]. J Am Stat Assoc.

Funding Opportunities

  • Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18, Clinical Trials Not Allowed)
  • Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R01, R21, Clinical Trial Not Allowed)
  • Health Care Models for Persons with Multiple Chronic Conditions from Populations that Experience Health Disparities: Advancing Health Care towards Health Equity (R01, Clinical Trials Optional)
  • Maintaining and Enriching Environmental Epidemiology Cohorts to Support Scientific and Workforce Diversity (U24, Clinical Trial Not Allowed)*
  • Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03, Clinical Trial Not Allowed)
  • Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01, U01, U54, P01, P50, U2C, Clinical Trial Optional)
  • US and Low- and Middle-Income Country HIV-Associated Malignancy Research Centers (U54, Clinical Trial Optional)
  • Exploratory Grants in Cancer Control (R21, Clinical Trial Optional)
  • Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01, Clinical Trial Optional)
  • Notice of Special Interest (NOSI): Disparities Affecting Healthcare Utilization and Health Outcomes Among Childhood Cancer Survivors (NOT-CA-22-029)
  • NOSI: Understanding the Effects of Cancer and Cancer Treatment on Aging Trajectories and Aging Outcomes (NOT-CA-21-031)
  • NOSI: Development and Implementation of Clinical Informatics Tools to Enhance Patients’ Use of Genomic Information (NOT-HG-22-011)*
  • NOSI: Validation of Digital Health and Artificial Intelligence Tools for Improved Assessment in Epidemiological, Clinical, and Intervention Research (NOT-CA-22-037)
  • NOSI: Clinical Characterization and Intervention Strategies for Cancer Therapy Induced Adverse Sequelae (NOT-CA-22-005)
  • NOSI: Improving Outcomes in Cancer Treatment-Related Cardiotoxicity (NOT-CA-22-001)
  • Notice of NCI’s Participation in PAR-20-070, “Research Infrastructure for Interdisciplinary Aging Studies (R21/R33 – Clinical Trial Optional” (NOT-CA-22-023)
  • Notice of Intent to Publish Funding Opportunity Announcements for the RADx-UP Initiative (Phase III) (NOT-OD-22-051)

* Note: NCI is not participating in this funding opportunity/NOSI.

Requests for Information

  • Inviting Comments and Suggestions on the Draft NIH Chief Officer for Scientific Workforce Diversity Strategic Plan for FYs 2022-2026. (NOT-OD-22-054, responses due February 10, 2022)
  • Proposed Updates and Long-Term Considerations for the NIH Genomic Data Sharing Policy (NOT-OD-22-029, responses due February 28, 2022)
  • Research Challenges and Needs in the Interaction of Sleep and Emotion Regulation to Improve Health and Well-being Across Health Conditions (NOT-OD-22-053, responses due February 28, 2022)

Grants Policy Notices and Information

Career and Training Opportunities

Research Resources

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