May 2022 EGRP Cancer Epidemiology News

EGRP Cancer Epidemiology News


NIH & NCI-Funded Genomics Datasets for Secondary Analysis

NIH and NCI have invested significantly in the generation of large-scale genomic data. These data are available through controlled access, in accord with the NIH Genomic Data Sharing Policy. Extramural investigators are encouraged to use the data for secondary analyses. Data availability from two major initiatives are highlighted below.

NCI’s Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative was established to advance discovery and characterization of genetic variants associated with cancer risk. The initiative was comprised of three major projects – Discovery, Biological Studies, and Epidemiologic Studies – and included investigators from all over the world. Members of GAME-ON developed the OncoArray chip, a >500K SNP-genotyping chip with content relevant to the discovery and analysis of cancer genetic risk variants. Working together, members of GAME-ON used the OncoArray chip to genotype over 400,000 individuals (40% with African, Hispanic, or Asian ancestry) for several types of cancer. The initiative focused on breast, prostate, colorectal, lung, and ovarian cancer, but the OncoArray chip has been used to search for variants that increase risk for other cancer types.

All the data generated by the GAME-ON initiative are now available in NIH’s Database of Genotypes and Phenotypes (dbGaP). Links to specific dbGaP datasets, by cancer type, are provided in the data sharing section of this GAME-ON infographic. To request access to dbGaP data, start here: https://dbgap.ncbi.nlm.nih.gov.

NIH’s All of Us Research Program is designed to gather health data, including genomic information, from more than 1 million people living in the United States. In March 2022, All of Us made its first genomic dataset available to scientists across the U.S. for a wide range of studies. The dataset includes whole genome sequences of nearly 100,000 participants, with nearly 50% from individuals who self-identify with a racial or ethnic minority group. It also includes genotyping arrays from 165,000 participants. The genomic data are available via a cloud-based platform, the All of Us Researcher Workbench. Read more in this announcement from the All of Us program.

Funding Opportunities

  • Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts (U01, Clinical Trial Not Allowed) *
  • Research Opportunities in Established Cancer Epidemiology Cohort Studies (U01, Clinical Trial Not Allowed) *
  • Cancer Prevention, Detection, Diagnosis, and Treatment Technologies for Global Health (U01, Clinical Trial Optional)
  • Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes (R01, Clinical Trial Optional)
  • NIH Directors Pioneer Award Program (DP1, Clinical Trial Optional)
  • NIH Directors New Innovator Award Program (DP2, Clinical Trial Optional)
  • SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44, Clinical Trial Optional)
  • Notice of Special Interest (NOSI): Administrative Supplements for Examining Patterns of Tobacco and Cannabis Use (NOT-CA-22-070)
  • NOSI: Administrative Supplements for Research on Womens Health in the IDeA States (NOT-GM-22-005)
  • Notice of Intent to Publish a Funding Opportunity Announcement for PHS 2022-2 Omnibus Solicitations of the NIH, CDC, and FDA for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Applications (NOT-OD-22-101)
  • Notice of Intent to Publish a Funding Opportunity Announcement for Research to Understand and Address the Survivorship Needs of Individuals Living with Advanced Cancer (NOT-CA-22-077)

* A recording of the April 27 pre-application webinar for these FOAs will be available at https://epi.grants.cancer.gov/cohorts/.

Requests for Information

Grants Policy Notices

  • Notice of Fiscal Policies in Effect for FY 2022 (NOT-OD-22-105)

Job and Fellowship Opportunities at NIH

Research Resources

NCI and NIH News

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