Skip to Main Content
An official website of the United States government
Epidemiology and Genomics Research Program

February 2023 EGRP Cancer Epidemiology News

EGRP Cancer Epidemiology News

February 2023

Announcing EGRP's 2022 Research Highlights!

Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. EGRP asked NCI grantees with projects supported by current or recently closed grants (i.e., grants that ended in 2021 or 2022) administered by EGRP to select and submit a research publication resulting from the grant. Submitted articles had to include an acknowledgement of the grant funding and comply with all NIH data sharing policies.

Below are the final selections for EGRP's 2022 Research Highlights, listed in alphabetical order by first author.

Reproducibility, validity, and relative validity of self-report methods for assessing physical activity in epidemiologic studies: findings from the Women's Lifestyle Validation Study

Al-Shaar L, Pernar CH, Chomistek AK, et al. Reproducibility, validity, and relative validity of self-report methods for assessing physical activity in epidemiologic studies: findings from the Women's Lifestyle Validation Study. Am J Epidemiol. 2022;191(4):696-710.

Western-style diet, pks Island-Carrying Escherichia coli, and colorectal cancer: analyses from two large prospective cohort studies

Arima K, Zhong R, Ugai T, et al. Western-style diet, pks Island-Carrying Escherichia coli, and colorectal cancer: analyses from two large prospective cohort studies. Gastroenterology. 2022;163(4):862-874.

Association between germline variants and somatic mutations in colorectal cancer

Barfield R, Qu C, Steinfelder RS, et al. Association between germline variants and somatic mutations in colorectal cancer. Sci Rep. 2022;12(1):10207.

Molecular and pathology features of colorectal tumors and patient outcomes are associated with Fusobacterium nucleatum and its subspecies animalis

Borozan I, Zaidi SH, Harrison TA, et al. Molecular and pathology features of colorectal tumors and patient outcomes are associated with Fusobacterium nucleatum and its subspecies animalis. Cancer Epidemiol Biomarkers Prev. 2022;31(1):210-220.

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

Byun J, Han Y, Li Y, et al. Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. Nat Genet. 2022;54(8):1167-1177.

Bile acid distributions, sex-specificity, and prognosis in colorectal cancer

Cai Y, Shen X, Lu L, et al. Bile acid distributions, sex-specificity, and prognosis in colorectal cancer. Biol Sex Differ. 2022;13(1):61.

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Cavazos TB, Kachuri L, Graff RE, et al. Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies. BMC Med. 2022;20(1):332.

Association of disparities in family history and family cancer history in the electronic health record with sex, race, Hispanic or Latino ethnicity, and language preference in 2 large US health care systems

Chavez-Yenter D, Goodman MS, Chen Y, et al. Association of disparities in family history and family cancer history in the electronic health record with sex, race, Hispanic or Latino ethnicity, and language preference in 2 large US health care systems. JAMA Netw Open. 2022;5(10):e2234574.

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Chen H, Fan S, Stone J, et al. Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci. Breast Cancer Res. 2022;24(1):27.

Evaluating breast cancer predisposition genes in women of African ancestry

Díaz-Zabala H, Guo X, Ping J, et al. Evaluating breast cancer predisposition genes in women of African ancestry. Genet Med. 2022;24(7):1468-1475.

Control of Epstein-Barr virus (EBV) in the oral cavity is associated with persistence of oral human papillomavirus (HPV)16/18 among men from the HPV infection in men study

Dickey BL, Giuliano AR, Sirak B, et al. Control of Epstein-Barr virus (EBV) in the oral cavity is associated with persistence of oral human papillomavirus (HPV)16/18 among men from the HPV infection in men study. J Infect Dis. 2023;227(2):256-260.

Operationalizing the exposome using passive silicone samplers

Fuentes ZC, Schwartz YL, Robuck AR, Walker DI. Operationalizing the exposome using passive silicone samplers. Curr Pollut Rep. 2022;8(1):1-29.

Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk

Grasso C, Popovic M, Isaevska E, et al. Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk. Cancer Epidemiol Biomarkers Prev. 2022;31(9):1769-1779.

Consumption of olive oil and risk of total and cause-specific mortality among US adults

Guasch-Ferré M, Li Y, Willett WC, et al. Consumption of olive oil and risk of total and cause-specific mortality among US adults. J Am Coll Cardiol. 2022;79(2):101-112.

Global and regional estimates of orphans attributed to maternal cancer mortality in 2020

Guida F, Kidman R, Ferlay J, et al. Global and regional estimates of orphans attributed to maternal cancer mortality in 2020. Nat Med. 2022;28(12):2563-2572.

Racial disparities in epithelial ovarian cancer survival: an examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium

Harris HR, Guertin KA, Camacho TF, et al. Racial disparities in epithelial ovarian cancer survival: an examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium. Int J Cancer. 2022;151(8):1228-1239.

Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers

He J, Wen W, Beeghly A, et al. Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers. Nat Commun. 2022;13(1):7118.

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

Islam SMA, Díaz-Gay M, Wu Y, et al. Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor. Cell Genom. 2022;2(11):None.

Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics

Jia G, Ping J, Shu X, et al. Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics. Am J Hum Genet. 2022;109(12):2185-2195.

Beyond GWAS of colorectal cancer: evidence of interaction with alcohol consumption and putative causal variant for the 10q24.2 region

Jordahl KM, Shcherbina A, Kim AE, et al. Beyond GWAS of colorectal cancer: evidence of interaction with alcohol consumption and putative causal variant for the 10q24.2 region. Cancer Epidemiol Biomarkers Prev. 2022;31(5):1077-1089.

Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Kim MS, Naidoo D, Hazra U, et al. Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa. Genome Biol. 2022;23(1):194.

Polygenic risk score and risk of monoclonal B-cell lymphocytosis in Caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans

Kleinstern G, Weinberg JB, Parikh SA, et al. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in Caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2022;36(1):119-125.

Multi-DNA adduct and abasic site quantitation in vivo by nano-liquid chromatography/high-resolution Orbitrap tandem mass spectrometry: methodology for biomonitoring colorectal DNA damage

Konorev D, Yao L, Turesky RJ. Multi-DNA adduct and abasic site quantitation in vivo by nano-liquid chromatography/high-resolution Orbitrap tandem mass spectrometry: methodology for biomonitoring colorectal DNA damage. Chem Res Toxicol. 2022;35(9):1519-1532.

Chemotherapy regimens received by women with BRCA1/2 pathogenic variants for early stage breast cancer treatment

Kurian AW, Abrahamse P, Hamilton AS, et al. Chemotherapy regimens received by women with BRCA1/2 pathogenic variants for early stage breast cancer treatment. JNCI Cancer Spectr. 2022;6(4):pkac045.

Risk of cardiometabolic risk factors in women with and without a history of breast cancer: the Pathways Heart Study

Kwan ML, Cheng RK, Iribarren C, et al. Risk of cardiometabolic risk factors in women with and without a history of breast cancer: the Pathways Heart Study. J Clin Oncol. 2022;40(15):1635-1646.

Impact of integrating genomic data into the electronic health record on genetics care delivery

Lau-Min KS, McKenna D, Asher SB, et al. Impact of integrating genomic data into the electronic health record on genetics care delivery. Genet Med. 2022;24(11):2338-2350.

Somatic mutational profiles and germline polygenic risk scores in human cancer

Liu Y, Gusev A, Heng YJ, Alexandrov LB, Kraft P. Somatic mutational profiles and germline polygenic risk scores in human cancer. Genome Med. 2022;14(1):14.

A guide to accelerated direct digital counting of single nucleic acid molecules by FRET-based intramolecular kinetic fingerprinting

Mandal S, Khanna K, Johnson-Buck A, Walter NG. A guide to accelerated direct digital counting of single nucleic acid molecules by FRET-based intramolecular kinetic fingerprinting. Methods. 2022;197:63-73.

Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers

Martinez-Fundichely A, Dixon A, Khurana E. Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers. Nat Commun. 2022;13(1):5640.

Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: results from the African American Cancer Epidemiology Study

McBride CM, Pathak S, Johnson CE, et al. Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: results from the African American Cancer Epidemiology Study. Cancer. 2022;128(6):1252-1259.

Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer

Nakamura K, Reid BM, Chen A, et al. Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer. Am J Hum Genet. 2022;109(1):116-135.

Racial differences in the tumor immune landscape and survival of women with high-grade serous ovarian carcinoma

Peres LC, Colin-Leitzinger C, Sinha S, et al. Racial differences in the tumor immune landscape and survival of women with high-grade serous ovarian carcinoma. Cancer Epidemiol Biomarkers Prev. 2022;31(5):1006-1016.

Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians

Ping J, Yang Y, Wen W, et al. Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians. Int J Cancer. 2022;151(10):1726-1736.

A healthy lifestyle in men at increased genetic risk for prostate cancer

Plym A, Zhang Y, Stopsack KH, et al. A healthy lifestyle in men at increased genetic risk for prostate cancer. [published online ahead of print, 2022 May 27]. Eur Urol. 2022;S0302-2838(22)02342-9.

Multilevel factors for adiposity change in a population-based prospective study of Black breast cancer survivors

Qin B, Kim K, Goldman N, et al. Multilevel factors for adiposity change in a population-based prospective study of Black breast cancer survivors. J Clin Oncol. 2022;40(20):2213-2223.

Insulinemic potential of diet and risk of total and subtypes of breast cancer among US females

Romanos-Nanclares A, Tabung FK, Willett WC, et al. Insulinemic potential of diet and risk of total and subtypes of breast cancer among US females. Am J Clin Nutr. 2022;116(6):1530-1539.

Joint associations of race, ethnicity, and socioeconomic status with mortality in the Multiethnic Cohort Study

Sangaramoorthy M, Shariff-Marco S, Conroy SM, et al. Joint associations of race, ethnicity, and socioeconomic status with mortality in the Multiethnic Cohort Study. JAMA Netw Open. 2022;5(4):e226370.

Multiregional sequencing analysis reveals extensive genetic heterogeneity in gastric tumors from Latinos

Toal T, Estrada-Florez A, Polanco-Echeverry G, et al. Multiregional sequencing analysis reveals extensive genetic heterogeneity in gastric tumors from LatinosExternal Web Site Policy. Cancer Res Commun. 2022;2(11):1487–1496.

Causes of death in low-grade B-cell lymphomas in the rituximab era: a prospective cohort study

Tun AM, Khurana A, Mwangi R, et al. Causes of death in low-grade B-cell lymphomas in the rituximab era: a prospective cohort study. Blood Adv. 2022;6(17):5210-5221.

molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history

Usyk M, Schlecht NF, Pickering S, et al. molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history. Nat Commun. 2022;13(1):233.

Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors

Wang X, Barrera C, Bera K, et al. Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors. Sci Adv. 2022;8(22):eabn3966.

Sociocultural factors, access to healthcare, and lifestyle: multifactorial indicators in association with colorectal cancer risk

Warren Andersen S, Zheng W, Steinwandel M, Murff HJ, Lipworth L, Blot WJ. Sociocultural factors, access to healthcare, and lifestyle: multifactorial indicators in association with colorectal cancer risk. Cancer Prev Res (Phila). 2022;15(9):595-603.

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation

Yanchus C, Drucker KL, Kollmeyer TM, et al. A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. Science. 2022;378(6615):68-78.

Reduction in total and major cause-specific mortality from tobacco smoking cessation: a pooled analysis of 16 population-based cohort studies in Asia

Yang JJ, Yu D, Shu XO, et al. Reduction in total and major cause-specific mortality from tobacco smoking cessation: a pooled analysis of 16 population-based cohort studies in Asia. Int J Epidemiol. 2022;50(6):2070-2081.

Information-incorporated Gaussian graphical model for gene expression data

Yi H, Zhang Q, Lin C, Ma S. Information-incorporated Gaussian graphical model for gene expression data. Biometrics. 2022;78(2):512-523.

Biomarker-calibrated red and combined red and processed meat intakes with chronic disease risk in a cohort of postmenopausal women

Zheng C, Pettinger M, Gowda GAN, et al. Biomarker-calibrated red and combined red and processed meat intakes with chronic disease risk in a cohort of postmenopausal women. J Nutr. 2022;152(7):1711-1720.

UACA locus is associated with breast cancer chemoresistance and survival

Zhu Q, Schultz E, Long J, et al. UACA locus is associated with breast cancer chemoresistance and survival. NPJ Breast Cancer. 2022;8(1):39.

Funding Opportunities

  • RFA-PM-23-001, Enhancing the Use of the All of Us Research Program’s Data (R21, Clinical Trial Not Allowed)
  • RFA-PM-23-002, Small Grants to Enhance the Use of the All of Us Research Program’s Data (R03, Clinical Trial Not Allowed)
  • Innovative Molecular Analysis Technologies (IMAT) Program RFAs
  • PA-23-048, Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (Parent T32)
  • PAR-23-035, Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01, Clinical Trial Not Allowed)
  • NOT-CA-23-018, Notice of Special Interest (NOSI): Research on the Etiology, Early Detection, Screening and Prevention of Early-Onset Colorectal Cancer
  • NOT-CA-23-037, NOSI: Technology Development for Cancer Control and Population Science Research
  • NOT-MD-23-002, NOSI: Addressing the Etiology of Health Disparities and Health Advantages Among Immigrant Populations
  • NOT-MD-23-003, NOSI Addressing Health Disparities Among Immigrant Populations Through Effective Interventions
  • NOT-OD-23-046, NOSI: Research on Gender Measurement (Admin Supp, Clinical Trial Optional)
  • NOT-OD-23-070, NOSI: Administrative Supplements to Support the Exploration of Cloud in NIH-supported Research

Request for Information

  • NOT-OD-23-034, Proposed Simplified Review Framework for NIH Research Project Grant Applications (responses requested by March 10, 2023)
  • NOT-CA-23-023, Request for Information (RFI) on Existing Data Sharing Processes for NIH-Funded Research (responses requested by April 3, 2023)

Grants Policy Announcements

Career and Training Opportunities

News and Blog Posts

Stay Connected

Subscribe for Updates

Subscribe
You can subscribe and unsubscribe at any time by entering your email address and selecting your preferences on the page that follows.

Subscribe to the E-Newsletter

Need Help?

EGRP staff can answer questions on grant funding, policies, and research resources. If you do not know who to contact we will do our best to connect you with someone who can help you.

Email Us
(240) 276-6730
Last Updated: 15 Mar, 2023