June 4-5, 2014 in Rockville, MD
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Overview
The 1.5-day "Using Immune Marker Panels to Uncover the Role of Inflammation in Cancer" workshop was sponsored by the Epidemiology and Genomics Research Program (EGRP) in NCI's Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Epidemiology and Genetics (DCEG). Representatives from institutions involved in studies of inflammation and cancer using technologies to assay inflammatory proteins were invited to share their experiences with new technologies and findings from association studies. At the end of the workshop, participants defined areas of consensus, and identified and summarized knowledge gaps.
Carol Weil, JD
Program Director, Ethical and Regulatory Affairs
Cancer Diagnosis Program
Division of Cancer Treatment and Diagnosis
carol.weil@nih.gov
Agenda
The workshop sessions included discussion of disease associations, biological interpretation of findings, assay performance, and statistical considerations.
View agenda for Wednesday, June 4
June 4, 2014 | Topic |
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8:15 a.m. | Registration |
8:30 a.m. |
Welcome Allan Hildesheim, PhD |
Session 1: Ongoing Studies With Inflammatory Marker Panel Assays and Disease Associations in Prospective Cohorts Chairs: Anil Chaturvedi, PhD, DCEG, NCI and Meredith Shiels, PhD, MHS, DCEG, NCI |
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9:00 a.m. |
Introduction to the Session Anil Chaturvedi, PhD DCEG, NCI |
9:05 a.m. |
Studies Within NCI Cohorts—Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study Mark Purdue, PhD DCEG, NCI |
9:25 a.m. |
Cytokines Associated With Development of Cirrhosis and Hepatocellular Carcinoma in Patients With Chronic Hepatitis Hwai-I Yang, PhD Academia Sinica |
9:45 a.m. |
Studies in the California Birth Cohort Joseph Wiemels, PhD University of California, San Francisco |
10:05 a.m. | Break |
10:20 a.m. |
Studies in the Women's Health Initiative Cohort Gloria Ho, PhD, MPH Albert Einstein College of Medicine |
10:40 a.m. |
Studies in the International Agency for Research on Cancer (IARC) and European Studies Mattias Johansson, PhD IARC |
11:00 a.m. |
Studies in the Vanderbilt Cohorts Wei Zheng, MD, PhD Vanderbilt University |
11:20 a.m. |
Studies on Epidemiologic Correlates of Inflammation Marker Levels Dr. Shiels DCEG, NCI |
11:40 a.m. | Panel Discussion |
12:30 p.m. | Lunch |
Session 2: Biologic Interpretation of Marker Association Studies Chair: Ron Germain, MD, PhD, National Institute of Allergy and Infectious Diseases (NIAID) |
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1:00 p.m. |
Introduction to the Session Ron Germain, MD, PhD National Institute of Allergy and Infectious Diseases (NIAID) |
1:10 p.m. |
Immunologic Perspectives on Exposure/Disease Associations in Epidemiologic Studies - Soluble Receptors and Cytokines Daniel McVicar, PhD Center for Cancer Research, NCI |
1:30 p.m. |
Immunologic Perspectives on Exposure/Disease Associations in Epidemiologic Studies - Chemokines Joshua Farber, MD NIAID |
1:50 p.m. |
Local Versus Systemic Markers of Inflammation Ron Germain, MD, PhD National Institute of Allergy and Infectious Diseases (NIAID) |
2:10 p.m. | Panel Discussion |
3:10 p.m. | Break |
Session 3: State of the Science on Multiplexed Inflammation Marker Platforms/Assays Chair: Ligia Pinto, PhD, Leidos |
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3:30 p.m. |
Introduction to the Session Ligia Pinto, PhD Leidos |
3:40 p.m. |
An Overview of Approaches for Detection of Immune Markers in Serum and Plasma Phil McCoy, PhD National Heart, Lung, and Blood Institute (NHLBI) |
4:00 p.m. |
Multiplexed Immunometric Assays for the Quantification of Biomarkers of Inflammation: Stability, Reproducibility, and Selection of Biomarkers Otoniel Martinez-Maza, PhD University of California, Los Angeles |
4:20 p.m. |
Standardization of Multiplex Assays and Evaluation of Performance Jay Bream, PhD The Johns Hopkins University |
4:40 p.m. | Panel Discussion |
5:30 p.m. | Wrap Up |
5:40 p.m. | Adjournment |
View agenda for Thursday, June 5
June 5, 2014 | Topic |
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Session 4: Statistical issues in MIP Studies Chair: Ruth Pfeiffer, PhD, DCEG, NCI |
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8:15 a.m. |
Introduction to the Session Ruth Pfeiffer, PhD DCEG, NCI |
8:20 a.m. |
Conceptual and Inferential Considerations in the Design and Analysis of Circulating Inflammatory Markers in Relation to Cancer Incidence and Outcomes Elizabeth Platz, ScD The Johns Hopkins University |
8:40 a.m. |
Assessing Assay Reproducibility and the Impact of Measurement Errors on Epidemiological Analyses Hormuzd Katki, PhD DCEG, NCI |
9:00 a.m. |
Dimensionality Reduction Methods for Multivariate Cytokines Data Ravi Varadhan, PhD The Johns Hopkins University |
9:20 a.m. | Panel Discussion |
10:00 a.m. | Break |
Session 5: Break-Out Groups and Wrap-Up Session Chairs: Drs. Verma and Hildesheim |
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10:20 a.m. |
Break-Out Groups 3 break-out groups were formed to discuss what we have learned from this meeting about the state of the science, gaps, and research strategies for the future.
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Workshop Wrap-Up and Discussion of Future Needs | |
11:20 a.m. |
Laboratory Methods: Future Needs Dr. Pinto, Rapporteur |
11:35 a.m. |
Epidemiological Studies and Statistical Considerations: Future Needs Dr. Shiels, Rapporteur |
11:50 a.m. |
Epidemiology-Immunology Interface, Functional studies: Future needs Dr. Hildesheim, Rapporteur |
12:05 p.m. | Conclusion and Recommendations |
12:20 p.m. | Adjournment |
Planning Committee
- Danielle Carrick, PhD, MHS, Program Director, Genomic Epidemiology Branch, EGRP, DCCPS, NCI
- Anil Chaturvedi, PhD, Investigator, Infections and Immunoepidemiology Branch, DCEG, NCI
- Rao Divi, PhD, Program Director, Methods and Technologies Branch, EGRP, DCCPS, NCI
- Kelly Filipski, PhD, MPH, Program Director, Clinical and Translational Epidemiology Branch, EGRP, DCCPS, NCI
- Elizabeth Hebert, Cancer Research Training Award Fellow, Methods and Technologies Branch, EGRP, DCCPS, NCI
- Allan Hildesheim, PhD, Chief, Infections and Immunoepidemiology Branch, DCEG, NCI
- Muin Khoury, MD, PhD, Associate Director, EGRP, DCCPS, NCI
- Meredith Shiels, PhD, MHS, Research Fellow, Infections and Immunoepidemiology Branch, DCEG, NCI
- Joseph Su, PhD, MPH, Program Director, Environmental Epidemiology Branch, EGRP, DCCPS, NCI
- Mukesh Verma, PhD, Chief, Methods and Technologies Branch, EGRP, DCCPS, NCI