Contacts - Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative


Project Leadership and Key Personnel

All of the projects use NIH’s Multiple Principal Investigator model,External Web Site Policy in which a lead institution collaborates with multiple sites in the U.S. and internationally. The key personnel for each project are listed below.

ColoRectal Transdisciplinary Study (CORECT) (View abstractExternal Web Site Policy)

  • Administrative Core
  • Project 1: Discovery, Expansion, and Replication
  • Project 2: Biological Studies
    • Graham Casey, Ph.D., University of Southern California - Co-PI, Project Leader (bioExternal Web Site Policy)
    • Stephen Gruber, M.D., Ph.D., M.P.H., University of Southern California - Contact PI (bioExternal Web Site Policy)
    • Chris Carlson, Ph.D., Fred Hutchinson Cancer Research Center
    • Gerhard Coetzee, Ph.D., University of Southern California
    • David Conti, Ph.D., University of Southern California
    • Kimberly Siegmund, Ph.D., University of Southern California
  • Project 3: Epidemiologic Studies
    • Duncan Thomas, Ph.D., University of Southern California - Co-PI, Project Leader (bioExternal Web Site Policy)
    • Ulrike Peters, Ph.D., M.P.H., Fred Hutchinson Cancer Research Center - Co-PI, Project Leader (bioExternal Web Site Policy)
    • Peter Campbell, Ph.D., American Cancer Society
    • W. James Gauderman, Ph.D., University of Southern California
    • Li Hsu, Ph.D., Fred Hutchinson Cancer Research Center
    • Shu-Chen Huang, University of Michigan
    • Eric Jacobs, Ph.D., American Cancer Society
    • Mark Jenkins, Ph.D., University of Melbourne
    • Charles Kooperberg, Ph.D., Fred Hutchinson Cancer Research Center
    • Juan Lewinger, Ph.D., University of Southern California
    • Bhramar Mukherjee, Ph.D., University of Michigan
    • Kimberly Siegmund, Ph.D., University of Southern California

Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) (View abstractExternal Web Site Policy)

Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) (View abstractExternal Web Site Policy)

  • Administrative Core
    • Christopher Haiman, Sc.D., University of Southern California – Contact PI (bioExternal Web Site Policy)
    • Stephen Chanock, M.D., National Cancer Institute
    • Douglas Easton, Ph.D., University of Cambridge
    • Rosalind Eeles, M.A., Ph.D., F.R.C.P., F.R.C.R., The Institute of Cancer Research
    • Matthew Freedman, M.D., Dana Farber/Harvard Cancer Center
  • Project 1: Discovery, Expansion, Replication
    • Douglas Easton, Ph.D., University of Cambridge – Coordinating PI (bioExternal Web Site Policy)
    • Federico Canzian, Ph.D., German Cancer Research Center (DKFZ)
    • Rudolf Kaaks, Ph.D., German Cancer Research Center (DKFZ)
    • Peter Kraft, Ph.D., Harvard University
    • Timothy Rebbeck, Ph.D., Harvard University
    • Daniel Stram, Ph.D., University of Southern California
  • Project 2: Functional Consequences of Prostate Cancer Risk Loci
    • Matthew Freedman, M.D., Dana Farber/Harvard Cancer Center – Coordinating PI (bioExternal Web Site Policy)
    • Jiyoung Ahn, D.Phil., Ph.D., New York University
    • Gerhard Coetzee, Ph.D., University of Southern California
    • Greg Crawford, Ph.D., Duke University
    • Richard Flavin, M.D., Dana Farber/Harvard Cancer Center
    • Richard Hayes, D.D.S., Ph.D., New York University
    • Jonathan Melamed, M.D., New York University
    • Ian Mills, Ph.D., Center for Molecular Medicine Norway
    • David Neal, B.Sc., M.S., F.R.C.S., F.R.C.S.(Ed), F.MED.SCI., University of Cambridge
    • Itshack Pe'er, Ph.D., M.D., Columbia University
    • Zoltan Szallasi, M.D., Children's Hospital Boston
  • Project 3: Epidemiological and Clinical Translational Studies Post-GWAS
    • Rosalind Eeles, M.A., Ph.D., F.R.C.P., F.R.C.R., The Institute of Cancer Research – Coordinating PI (bioExternal Web Site Policy)
    • Frederick Schumacher, Ph.D., University of Southern California
    • Federico Canzian, Ph.D., German Cancer Research Center (DKFZ)
    • Rudolf Kaaks, Ph.D., German Cancer Research Center (DKFZ)
    • Peter Kraft, Ph.D., Harvard University
    • Kristine Monroe, Ph.D., University of Southern California
    • Timothy Rebbeck, Ph.D., Harvard University

Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) (View abstractExternal Web Site Policy)

  • Administrative Core
  • Project 1: Ovarian Cancer GWAS Discovery, Expansion, and Replication
    • Thomas Sellers, Ph.D., M.P.H., H. Lee Moffitt Cancer Center & Research Institute – Project Leader (bioExternal Web Site Policy)
    • Ellen Goode, Ph.D., Mayo Clinic Rochester
    • Paul Pharoah, M.D., Ph.D., University of Cambridge
    • Georgia Chenevix-Trench, Ph.D., Queensland Institute of Medical Research
    • Hui-Yi Lin, Ph.D., H. Lee Moffitt Cancer Center & Research Institute
  • Project 2: Functional Assessment of Genes and Common Genetic Risk Variants in Ovarian Cancer
    • Alvaro Monteiro, Ph.D., H. Lee Moffitt Cancer Center & Research Institute – Project Leader (bioExternal Web Site Policy)
    • Greg Bloom, Ph.D., H. Lee Moffitt Cancer Center & Research Institute
    • Simon Gayther, Ph.D., Cedars Sinai Medical Center
    • Catherine Phelan, Ph.D., M.D., M.M.S., H. Lee Moffitt Cancer Center & Research
    • Susan Ramus, Ph.D., University College of London
  • Project 3: Genetic and Environmental Interaction Analyses and Risk Prediction Modeling
    • Joellen Schildkraut, Ph.D., M.P.H., University of Virginia School of Medicine – Project Leader
    • Andrew Berchuck, Ph.D., Duke University
    • Merlise Clyde, Ph.D., Duke University
    • Edwin Iversen, Ph.D., Duke University
    • Celeste Leigh Pearce, Ph.D., M.P.H., USC
    • Harvey Risch, M.D., Ph.D., Yale University
    • Mary Ann Rossing, Ph.D., Fred Hutchinson Cancer Research Center
    • Anna Wu, Ph.D., M.P.H., USC

Transdisciplinary Research in Cancer of the Lung (TRICL) (View abstractExternal Web Site Policy)

  • Administrative Core
    • Christopher Amos, Ph.D., Dartmouth College - PI, Project Leader (bioExternal Web Site Policy)
    • Rayjean Hung, Ph.D., Samuel Lunenfeld Research Institute, Mount Sinai Hospital (Toronto, Ontario) – PI, Project Leader (bioExternal Web Site Policy)
    • Mala Pande, Ph.D., The University of Texas M.D. Anderson Cancer Center
    • Margaret Spitz, M.D., Ph.D., Baylor College of Medicine
  • Project 1: Discovery and Replication

    Key Personnel

    • Christopher Amos, Ph.D., Dartmouth College - PI, Project Leader (bioExternal Web Site Policy)
    • Paul Brennan, Ph.D., International Agency for Research on Cancer (IARC) – PI, Project Leader (bioExternal Web Site Policy)
    • Paolo Boffetta, M.D., M.P.H., Mount Sinai School of Medicine – PI (bioExternal Web Site Policy)
    • Richard Houlston, Ph.D., The Institute of Cancer Research – PI (bioExternal Web Site Policy)
    • Rayjean Hung, Ph.D., Samuel Lunenfeld Research Institute, Mount Sinai Hospital (Toronto, Ontario) – PI (bioExternal Web Site Policy)
    • Thorunn Rafnar, Ph.D., deCODE Genetics Inc. – PI
    • Hongbing Shen, M.D., Ph.D., Nanjing Medical University – PI (bioExternal Web Site Policy)
    • Ann Schwartz, Ph.D., M.P.H., Wayne State University – PI (bioExternal Web Site Policy)
    • H. Erich Wichmann, M.D., Ph.D., University of Munich – PI
    • Heike Bickeböller, Ph.D., University of Göttingen
    • James McKay, Ph.D., IARC
    • Paul Scheet, Ph.D., The University of Texas M.D. Anderson Cancer Center
    • Sanjay Shete, Ph.D., The University of Texas M.D. Anderson Cancer Center
    • Xifeng Wu, M.D., Ph.D., The University of Texas M.D. Anderson Cancer Center
    • Mala Pande, Ph.D.. The University of Texas M.D. Anderson Cancer Center
    • Clive Hoggart, Ph.D., Imperial College
    • Ignacio Wistuba, M.D., The University of Texas M.D. Anderson Cancer Center
    • Paolo Vineis, M.D., Ph.D., Imperial College

    Additional Personnel

    • Melanie Sohns, Ph.D., University of Göttingen
    • Yufei Wang, Ph.D., The Institute of Cancer Research
    • Tere Landi, M.D., Ph.D., National Cancer Institute
    • Gudmar Thorfeifsson, Ph.D., deCODE Genetics Inc.
    • Maria Timofeeva, Ph.D., International Agency for Research on Cancer (IARC)
    • Nilanjan Chatterjee, Ph.D., Johns Hopkins University
    • John Field, Ph.D., The Roy Castle Lung Cancer Foundation
  • Project 2: Functional Validation – Biological Studies

    Key Personnel

    • Ming You, M.D., Ph.D., Medical College of Wisconsin – PI, Project Leader (bioExternal Web Site Policy)
    • Christoph Plass, Ph.D., German Cancer Research Center (DKFZ) – PI, Project Leader (bioExternal Web Site Policy)
    • Mariella De Biasi, Ph.D., Baylor College of Medicine
    • Jay Tichelaar, Ph.D., Medical College of Wisconsin
    • Haris Vikis, Ph.D., Medical College of Wisconsin
    • Michael James, Medical College of Wisconsin
    • Angela Risch, Ph.D., German Cancer Research Center (DKFZ)
    • Ann Schwartz, Ph.D., M.P.H., Wayne State University

    Additional Personnel

    • Donghai Xiong, Ph.D., Medical College of Wisconsin
    • Dieter Weichenhan, Ph.D., German Cancer Research Center (DKFZ)
    • Wolfgang Hagmann, Ph.D., German Cancer Research Center (DKFZ)
  • Project 3:

    Key Personnel

    • Loic Le Marchand, M.D., M.P.H., Ph.D., Cancer Research Center of Hawaii, University of Hawaii – PI, Project Leader (bioExternal Web Site Policy)
    • Paolo Vineis, M.D., Ph.D., Imperial College
    • Jiali Han, Ph.D., Harvard University
    • Margaret Spitz, M.D., M.P.H., Baylor College of Medicine
    • Laura Jean Beirut, M.D., Washington University in St. Louis
    • Lynne Wilkens, Dr.P.H., Cancer Research Center of Hawaii, University of Hawaii
    • Iona Cheng, Ph.D., M.P.H., Cancer Prevention Institute of California
    • Jing Ma, Ph.D., M.D., Brigham and Women's Hospital
    • David Hunter, M.B.B.S., Sc.D., Harvard University
    • Mala Pande, Ph.D.. The University of Texas M.D. Anderson Cancer Center
    • Clive Hoggart, Ph.D., Imperial College

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Steering Committee

Management of GAME-ON is coordinated through the GAME-ON Steering Committee. The Steering Committee includes Program Officers from the Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Biology (DCB) as well as investigators from each of the five cancer site projects.

Voting Members

* Steering Committee Chair

NCI Participants

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External Advisory Committee

The External Advisory Committee will advise NCI on the overall progress of the Initiative, provide scientific advice to the Steering Committee and Principal Investigators on the overall conduct of the studies, and suggest future courses of action. Committee members were selected based on their areas of expertise.

External Advisory Committee Members:

  • Colin Begg, Ph.D., Memorial Sloan Kettering Cancer Center
  • Michael Boehnke, Ph.D., University of Michigan
  • Elizabeth Claus, M.D., Ph.D., Yale University
  • Adi Gazdar, M.B.B.S., University of Texas Southwestern Medical Center
  • Malcolm Mason, M.D., F.R.C.P., F.R.C.R., University of Wales
  • Deborah Nickerson, Ph.D.
  • Olofunmilayo Olopade, M.D., F.A.C.P., University of Chicago
  • Gloria Petersen, Ph.D., Mayo Clinic
  • Sylvia Plevritis, Ph.D., Stanford University
  • Sylvia Rickard, Utah Breast Cancer Network
  • Paul Spellman, Ph.D., Oregon Health & Science University

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