Radiogenomics Consortium (RGC)
- Organizational Structure
- Funding Sources
- Consortium Publications
The Radiogenomics Consortium was established in November 2009. The scientific hypothesis underlying the development of the consortium is that a cancer patient's likelihood of developing toxicity to radiation therapy is influenced by common genetic variations, such as single nucleotide polymorphisms (SNPs).
The Consortium members undertake collaborative projects to identify SNPs associated with adverse effects following radiotherapy, share data and samples, perform meta-analyses, and work together to submit research grant applications.
The objectives of the Radiogenomics Consortium are to expand knowledge of the genetic basis for differences in radiosensitivity and to develop assays to help predict the susceptibility of cancer patients for the development of adverse effects resulting from radiotherapy, through:
- Fostering international collaborative research projects in radiogenomics through sharing of biospecimens and data;
- Developing guidelines to improve the standardization of radiogenomics research;
- Providing a framework for the efficient conduct and publication of original data meta-analyses of relevant studies;
- Providing a forum and framework for discussion, development and pursuit of new research directions; and
- Supporting the development of early career researchers.
A Coordinating Committee was established to run the Consortium. The lead coordinators for the Radiogenomics Consortium are Barry Rosenstein, Ph.D., of Icahn School of Medicine at Mount Sinai, New York, and Catharine West, Ph.D., of the University of Manchester, UK.
Other members of the Committee are:
- Nicolaj Andreassen, M.D., Ph.D., of Aarhus University, Denmark
- Gill Barnett, B.M., B.Ch., Ph.D., of University of Cambridge, UK
- Soeren Bentzen, Ph.D., D.Sc., of University of Maryland, USA
- Jenny Chang-Claude, Ph.D., of German Cancer Research Center (DKFZ)
- Joe Deasy, Ph.D., of Memorial Sloan-Kettering Cancer Center, New York
- Alison Dunning, Ph.D., of University of Cambridge, UK
- Sarah Kerns, Ph.D., M.P.H., University of Rochester Medical Center, New York
- Matthew Parliament, M.D., of University of Alberta, Edmonton, Canada
- Ana Vega, Ph.D., of University of Santiago de Compostela, Spain
The Committee also includes a representative from the NCI, Nonniekaye Shelburne, C.R.N.P., M.S., A.O.C.N.
Lynda Rath of Icahn School of Medicine at Mount Sinai and Rebecca Elliot of the University of Manchester provide administrative support.
As of February 2016, membership of the Radiogenomics Consortium consists of 194 members in 26 countries across 115 institutions.
The Radiogenomics Consortium is open to all investigators interested in studying the relationship between genetic variation and radiation therapy toxicity.
Anyone interested in joining RGC should email Lynda Rath.
Support for logistical needs of the Consortium has been provided by NCI's Epidemiology and Genomics Research Program (EGRP) in the Division of Cancer Control and Population Sciences (DCCPS) and the Radiation Research Program (RRP) in the Division of Cancer Treatment and Diagnosis (DCTD). Many members of the RGC are principal or co-investigators for grants that support research in radiogenomics and receive funding from National Cancer Institute, European Commission, Cancer Research UK, Canadian Institutes of Health, US Department of Defense, Deustsche Krebshilfe e.V, Health Research Fund, National Science Centre, and Spanish Ministry of Health.
- Mavragani IV, Laskaratou DA, Frey B, Candéias SM, Gaipl US, Lumniczkyf K, Georgakilas AG. Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. Toxicol Res. 2016; 5: 12-33.
- Nikitaki Z, Mavragani IV, Laskaratou DA, Gika V, Moskvin VP, Theofilatos K, Vougas K, Stewart RD, Georgakilas AG. Systemic mechanisms and effects of ionizing radiation: A new 'old' paradigm of how the bystanders and distant can become the players. Semin Cancer Biol. 2016 Feb 9. [Epub ahead of print]
- Georgakilas AG. Role of the immune system and inflammation in ionizing radiation effects. Cancer Lett. 2015 Nov 28;368(2):154-5.
- Georgakilas AG, Pavlopoulou A, Louka M, Nikitaki Z, Vorgias CE, Bagos PG, Michalopoulos I. Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches. Cancer Lett. 2015 Nov 28;368(2):164-72.
- Barnett GC, Kerns SL, Noble DJ, Dunning AM, West CM, Burnet NG. Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity. Clin Oncol (R Coll Radiol). 2015 Oct;27(10):579-87.
- Kerns SL, Kundu S, Oh JH, Singhal SK, Janelsins M, Travis LB, Deasy JO, Janssens AC, Ostrer H, Parliament M, Usmani N, Rosenstein BS. The Prediction of Radiotherapy Toxicity Using Single Nucleotide Polymorphism-Based Models: A Step Toward Prevention. Semin Radiat Oncol. 2015 Oct;25(4):281-91.
- Pateras IS, Havaki S, Nikitopoulou X, Vougas K, Townsend PA, Panayiotidis MI, Georgakilas AG, Gorgoulis VG. The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where. Pharmacol Ther. 2015 Oct;154:36-56.
- Seibold P, Behrens S, Schmezer P, Helmbold I, Barnett G, Coles C, Yarnold J, Talbot CJ, Imai T, Azria D, Koch CA, Dunning AM, Burnet N, Bliss JM, Symonds RP, Rattay T, Suga T, Kerns SL, Bourgier C, Vallis KA, Sautter-Bihl ML, Claβen J, Debus J, Schnabel T, Rosenstein BS, Wenz F, West CM, Popanda O, Chang-Claude J. XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1084-92.
- Sprung CN, Ivashkevich A, Forrester HB, Redon CE, Georgakilas A, Martin OA. Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett. 2015 Jan 1;356(1):72-81.
- Rosenstein BS, West CM, Bentzen SM, Alsner J, Andreassen CN, Azria D, Barnett GC, Baumann M, Burnet N, Chang-Claude J, Chuang EY, Coles CE, Dekker A, De Ruyck K, De Ruysscher D, Drumea K, Dunning AM, Easton D, Eeles R, Fachal L, Gutiérrez-Enríquez S, Haustermans K, Henríquez-Hernández LA, Imai T, Jones GD, Kerns SL, Liao Z, Onel K, Ostrer H, Parliament M, Pharoah PD, Rebbeck TR, Talbot CJ, Thierens H, Vega A, Witte JS, Wong P, Zenhausern F; Radiogenomics Consortium. Radiogenomics: radiobiology enters the era of big data and team science. Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):709-13.
- Kerns SL, West CM, Andreassen CN, Barnett GC, Bentzen SM, Burnet NG, Dekker A, De Ruysscher D, Dunning A, Parliament M, Talbot C, Vega A, Rosenstein BS. Radiogenomics: the search for genetic predictors of radiotherapy response. Future Oncol. 2014 Dec;10(15):2391-406.
- Fachal L, Gómez-Caamaño A, Barnett GC, Peleteiro P, Carballo AM, Calvo-Crespo P, Kerns SL, Sánchez-García M, Lobato-Busto R, Dorling L, Elliott RM, Dearnaley DP, Sydes MR, Hall E, Burnet NG, Carracedo Á, Rosenstein BS, West CM, Dunning AM, Vega A. A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1. Nat Genet. 2014 Aug;46(8):891-4.
- Kerns SL, Ostrer H, Rosenstein BS. Radiogenomics: using genetics to identify cancer patients at risk for development of adverse effects following radiotherapy. Cancer Discov. 2014 Feb;4(2):155-65.
- Kerns SL, De Ruysscher D, Andreassen CN, Azria D, Barnett GC, Chang-Claude J, Davidson S, Deasy JO, Dunning AM, Ostrer H, Rosenstein BS, West CML, Bentzen SM for the Radiogenomics Consortium. STROGAR - Strengthening the Reporting Of Genetic Association studies in Radiogenomics. Radiotherapy and Oncology. 2014 Jan;110(1):182-8.
- De Ruysscher D, Sharifi H, Defraene G, Kerns SL, Christiaens M, De Ruyck K, Peeters S, Vansteenkiste J, Jeraj R, Van Den Heuvel F, van Elmpt W. Quantification of radiation-induced lung damage with CT scans: The possible benefit for radiogenomics. Acta Oncol. Epub August 21, 2013.
- Kerns SL, Stock RG, Stone NN, Blacksburg SR, Rath L, Vega A, Fachal L, Gómez-Caamaño A, De Ruysscher D, Lammering G, Parliament M, Blackshaw M, Sia M, Cesaretti J, Terk M, Hixson R, Rosenstein BS, Ostrer H. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. Radiotherapy and Oncology. Epub 28 May, 2013.
- Kerns SL, Stock R, Stone N, Buckstein M, Shao Y, Campbell C, Rath L, De Ruysscher D, Lammering G, Hixson R, Cesaretti J, Terk M, Ostrer H, Rosenstein BS. 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of erectile dysfunction following radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2013 Jan 1;85(1):e21-8.
- Barnett GC, Elliott RM, Alsner J, Andreassen CN, Abdelhay O, Burnet NG, Chang-Claude J, Coles CE, Gutiérrez-Enríquez S, Fuentes-Raspall MJ, Alonso-Muñoz MC, Kerns S, Raabe A, Symonds RP, Seibold P, Talbot CJ, Wenz F, Wilkinson J, Yarnold J, Dunning AM, Rosenstein BS, West CM, Bentzen SM. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. Radiother Oncol. 2012 Dec;105(3):289-95.
- Talbot CJ, Tanteles GA, Barnett GC, Burnet NG, Chang-Claude J, Coles CE, Davidson S, Dunning AM, Mills J, Murray RJ, Popanda O, Seibold P, West CM, Yarnold JR, Symonds RP. A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. Br J Cancer. 2012 Aug 7;107(4):748-53. doi: 10.1038/bjc.2012.290. Epub 2012 Jul 5. PMID:22767148
- De Ruyck K, Sabbe N, Oberije C, Vandecasteele K, Thas O, De Ruysscher D, Lambin P, Van Meerbeeck J, De Neve W, Thierens H. Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2011 Oct 1;81(2):537-44.
- West C, Rosenstein BS, Alsner J, Azria D, Barnett G, Begg A, Bentzen S, Burnet N, Chang-Claude J, Chuang E, Coles C, De Ruyck K, De Ruysscher D, Dunning A, Elliott R, Fachal L, Hall J, Haustermans K, Herskind C, Hoelscher T, Imai T, Iwakawa M, Jones D, Kulich C; EQUAL-ESTRO, Langendijk JH, O'Neils P, Ozsahin M, Parliament M, Polanski A, Rosenstein B, Seminara D, Symonds P, Talbot C, Thierens H, Vega A, West C, Yarnold J. Establishment of a Radiogenomics Consortium. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1295-6.
- West C, Rosenstein BS. Establishment of a radiogenomics consortium. Radiother Oncol. 2010 Jan;94(1):117-8.
- 8th Annual Radiogenomics Consortium Meeting
MAASTRO Clinic, Maastricht, Netherlands - July 13, 2016
- 7th Annual Radiogenomics Consortium Meeting
Montpelier, France, June 15-17, 2015
- European SocieTy for Radiotherapy & Oncology (ESTRO) 33
Vienna, Austria, April 4-8, 2014
- American Society for Radiation Oncology (ASTRO) Annual Meeting
San Francisco, CA, September 14-17, 2014
- 6th Annual Radiogenomics Consortium Meeting
Heidelberg, Germany, October 13, 2014
- RGC Annual Meeting
Cambridge, UK, October 16-17, 2013
- Pre-meeting before American Society for Radiation Oncology (ASTRO) Annual Meeting
Boston, MA, October 28, 2012
- Barry Rosenstein, Ph.D.
Icahn School of Medicine at Mount Sinai
- Catharine West, Ph.D.
University of Manchester
- Nonniekaye Shelburne, C.R.N.P., M.S., A.O.C.N.