Lung Cancer Cohort Consortium (LC3)

• Evaluating risk prediction models for use in lung cancer screening across diverse populations around the world

  • Participating Cohorts: Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Breakthrough Generations Study Canadian Study of Diet, Lifestyle, and Health Cancer Prevention Studies (CPS I, CPS II, CPS III, & CPS II Nutrition Cohort) CLUE II European Prospective Investigation into Cancer and Nutrition (EPIC) Golestan Cohort Study (GCS) Health Professionals Follow-Up Study (HPFS) Melbourne Collaborative Cohort Study Multiethnic Cohort Study of Diet and Cancer (MEC) NIH-AARP Diet and Health Study Northern Sweden Health and Disease Study Nurses' Health Study II (NHS II) NYU Women's Health Study Physicians' Health Study (PHS) I & II Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Shanghai Cohort Study Shanghai Men's Health Study (SMHS) Shanghai Women's Health Study (SWHS) Singapore Chinese Health Study Southern Community Cohort Study (SCCS) Vitamins and Lifestyle (VITAL) Study Women's Health Initiative (WHI) Women's Health Study (WHS)
  • Has funding been awarded?: Complete
  • Have contracts been signed?: Complete
  • Has data been transferred?: Complete
  • Summarized successes:
    • This project has led to the following manuscripts: (1) Robbins et al, British J Ca 2021 (results pertaining to the United Kingdom); (2) Feng et al, submitted (results pertaining to Europe except UK); (3) Guida and Feng et al, in preparation (results for USA, including by race/ethnicity); (4) Yang et al, J Thoracic Oncol 2023 (results pertaining to Asia, using data from the Asia Cohort Consortium as well as NCI Cohort Consortium).
  • Summarized challenges:

• Lung Cancer Calcium Intake Pooling Project

  • (This subproject has not submitted any Progress Reports)

Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). (2018)

Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins. (2018)

Impaired functional vitamin B6 status is associated with increased risk of lung cancer. (2018)

No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). (2018)

Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3). (2018)

Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. (2017)

Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies. (2017)

Serum B vitamin levels and risk of lung cancer. (2010)