A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

Pubmed ID: 20101243

Pubmed Central ID: PMC2853179

Journal: Nature genetics

Publication Date: March 1, 2010

Affiliation: Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

MeSH Terms: Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 5, Genetic Loci, Chromosomes, Human, Pair 1, Genome-Wide Association Study, Pancreatic Neoplasms, Carcinoma, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Linkage Disequilibrium, Humans, Cohort Studies, Case-Control Studies

Grants: ZIA CP010193-03, P50 CA062924-130011, K07 CA140790, P50 CA062924, P50 CA062924-140011, P50 CA062924-150011, P50 CA062924-160011, R37 CA070867, R01 CA082729, P50 CA102701, R01 CA124908, R01 CA097193

Authors: Howard B, Parikh H, Seminara D, Mandelson MT, Bamlet WR, Rodriguez L, de Andrade M, Van Den Eeden SK, Hassan M, Cotterchio M, Klein AP, Kurtz RC, Goggins M, Gallinger S, Bracci PM, Holly EA, Risch HA, Yu H, Li D, Duell EJ, Jenab M, Petersen GM, McWilliams RR, Rajkovic A, Wactawski-Wende J, Michaud DS, Wolpin BM, Boutron-Ruault MC, Tjønneland A, LaCroix A, Gross M, Helzlsouer K, Mendelsohn JB, Tobias GS, Clipp S, Hartge P, Amundadottir L, Jacobs EJ, Kooperberg C, Lynch SM, Stolzenberg-Solomon RZ, Zheng W, Shu XO, Olson SH, Bueno-de-Mesquita HB, Patel AV, Giovannucci EL, Berg CD, Hutchinson A, Yu K, Wang Z, Jacobs KB, Fraumeni JF Jr, Peeters PH, Trichopoulos D, Krogh V, Fuchs CS, Hoover RN, Hallmans G, Gaziano JM, Chanock SJ, Thomas G, Kaaks R, Canzian F, Kraft P, Riboli E, Buring JE, Hankinson SE, Arslan AA, Albanes D, Virtamo J, Zeleniuch-Jacquotte A, Hunter DJ

Cite As: Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF Jr, Hoover RN, Hartge P, Chanock SJ. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nature genetics. 2010 Mar.

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Genome-Wide Association Study for Pancreatic Cancer (PanScan3) (Standalone Project)

Abstract

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

Last Updated: 14 Mar, 2025