Resources - Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative
Tools Created by GAME-ON Investigators
GAME-ON investigators developed tools that can be used by the scientific community to further their research. More tools may be added to this page over time.
FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs.
The R/Bioconductor software package enables the identification of candidate functional SNPs by integrating information from tagSNP locations, lists of linked SNPs from the 1000 genomes project and locations of chromatin features which may have functional significance.
FunciSNP is available from Bioconductor.
GAME-ON GWAS Look-Up Tool
The GAME-ON GWAS look-up tool allows users to find association results between single nucleotide polymorphisms (SNPs) and overall as well as estrogen receptor negative (ER-) breast cancer risk. Users are able to search for a specific SNP, by gene or by genetic region.
GeneSigDB - a curated database of gene expression signatures.
GeneSigDB is a searchable resource providing access to gene signatures that have been manually curated from the literature and mapped to standard gene identifiers using a defined annotation pipeline. These standardized gene signatures facilitate the use of gene set enrichment methods and the search for common features among published datasets.
- GxEscan: software to detect GxE interactions in a genome-wide association study. GxEscan implements a variety of exhaustive and 2-step testing approaches. GxEscan is available for download from the University of Southern California.