Working Groups - Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative

Working Groups

The GAME-ON Initiative established working groups between the five projects in order to share expertise, spread knowledge across all five projects, and streamline results between cancer types. Working groups specialized in one scientific area and included experts from each of the five projects.

Analytic and Risk Modeling Working Group

The purpose of this working group was to develop models to characterize risk factors for cancer, share analytic approaches and develop analytic tools, and determine when risk models are ready to transition to the Epidemiology and Clinical Working Group.

Next Generation Genomics Technologies Working Group
Over the course of the project, the Next Generation Genomics Technologies Working Group was absorbed by the Analytic and Risk Modeling Working Group.


Epidemiology and Clinical Working Group

The purpose of this working group was to perform phenotypic, genotypic, survival, and pathology data harmonization and analysis; identify secondary phenotypes; and develop ideas for cross-project collaborations involving gene x environment interactions and new projects aimed at understanding the functional consequences of single nucleotide polymorphisms (SNPs) by using available biomarkers.

TERT-CLPTM1L Working Group
The purpose of this sub-group of the Epidemiology and Clinical Working Group was to determine which TERT-CLPTM1L SNPs are the most highly associated with a given cancer site; whether the susceptibility SNPs are similar or different across cancer sites; whether the associations vary by population; what the haplotype structures are across populations; and whether SNPs in this locus are associated with telomere length.


Epigenetics Working Group

The purpose of this working group was to investigate the relationship between epigenetic regulation and cancer risk in the GAME-ON consortium, by focusing on (a) inherited genetic variability in epigenetic regulators/pathways in relation to cancer risk, (b) stratified analysis of tumor phenotypes characterized by epigenetic dysregulation and (c) functional follow-up on GAME-ON hits with respect to epigenetic characteristic mechanisms in multiple interrelated studies.


Functional Assays Working Group

The purpose of this working group was to share approaches to the characterization of functional consequences of risk variants and to identify specific gene targets (e.g., regulatory) and how they interact.

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