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Epidemiology and Genomics Research Program

January 2024 EGRP Cancer Epidemiology News

EGRP Cancer Epidemiology News


2023 Research Highlights

Announcing EGRP’s 2023 Research Highlights!

Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. EGRP asked NCI grantees with projects supported by current or recently-closed grants (i.e., grants that ended in 2022 or 2023) administered by EGRP to select and submit a research publication resulting from the grant. Submitted articles had to include an acknowledgement of the grant funding and comply with all NIH data sharing policies.

Below are the final selections for EGRP's 2023 Research Highlights, listed in alphabetical order by first author.

A genetic locus within the FMN1/GREM1 gene region interacts with body mass index in colorectal cancer risk

Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer

Barrera C, Corredor G, Viswanathan VS, et al. Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer. NPJ Precis Oncol. 2023;7(1):52.

Age-related differences in employment, insurance, and financial hardship among colorectal cancer patients: a report from the ColoCare Study

Berghuijs KMVT, Kaddas HK, Trujillo G, et al. Age-related differences in employment, insurance, and financial hardship among colorectal cancer patients: a report from the ColoCare Study. J Cancer Surviv. Published online March 23, 2023.

Historical redlining and breast cancer treatment and survival among older women in the United States

Bikomeye JC, Zhou Y, McGinley EL, et al. Historical redlining and breast cancer treatment and survival among older women in the United States. J Natl Cancer Inst. 2023;115(6):652-661.

Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study

Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma

Chen P, Rojas FR, Hu X, et al. Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma. Mod Pathol. Published online September 9, 2023.

Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation

Chen Z, Song W, Shu XO, et al. Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation. J Natl Cancer Inst. Published online August 26, 2023.

Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry

Pathological imaging-assisted cancer gene-environment interaction analysis

Fang K, Li J, Zhang Q, Xu Y, Ma S. Pathological imaging-assisted cancer gene-environment interaction analysis. Biometrics. Published online May 17, 2023.

A joint transcriptome-wide association study across multiple tissues identifies candidate breast cancer susceptibility genes

Lipidome of mammographic breast density in premenopausal women

Getz KR, Jeon MS, Luo C, Luo J, Toriola AT. Lipidome of mammographic breast density in premenopausal women. Breast Cancer Res. 2023;25(1):121.

Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death

Gibbs DC, Thomas NE, Kanetsky PA, et al. Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death. JNCI Cancer Spectr. 2023;7(5):pkad051.

A novel human papillomavirus and host DNA methylation score and detection of cervical adenocarcinoma

Gradissimo A, Clarke MA, Xue X, et al. A novel human papillomavirus and host DNA methylation score and detection of cervical adenocarcinoma. J Natl Cancer Inst. 2023;115(12):1535-1543.

Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma

Guerra G, McCoy L, Hansen HM, et al. Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma. Neuro Oncol. 2023;25(6):1047-1057.

Examination of fully automated mammographic density measures using LIBRA and breast cancer risk in a cohort of 21,000 non-Hispanic White women

Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes

Accelerometer-measured physical activity and postmenopausal breast cancer incidence in the Women's Health Accelerometry Collaboration

Identification of target proteins for breast cancer genetic risk loci and blood risk biomarkers in a large study by integrating genomic and proteomic data

Longitudinal analysis of change in mammographic density in each breast and its association with breast cancer risk

Jiang S, Bennett DL, Rosner BA, Colditz GA. Longitudinal analysis of change in mammographic density in each breast and its association with breast cancer risk. JAMA Oncol. 2023;9(6):808-814.

Genetically adjusted PSA levels for prostate cancer screening

Kachuri L, Hoffmann TJ, Jiang Y, et al. Genetically adjusted PSA levels for prostate cancer screening. Nat Med. 2023;29(6):1412-1423.

Circulating proteome for pulmonary nodule malignancy

Khodayari Moez E, Warkentin MT, Brhane Y, et al. Circulating proteome for pulmonary nodule malignancy. J Natl Cancer Inst. 2023;115(9):1060-1070.

Potential utility of risk stratification for multicancer screening with liquid biopsy tests

Kim ES, Scharpf RB, Garcia-Closas M, Visvanathan K, Velculescu VE, Chatterjee N. Potential utility of risk stratification for multicancer screening with liquid biopsy tests. NPJ Precis Oncol. 2023;7(1):39.

Germline genetic testing after cancer diagnosis

Kurian AW, Abrahamse P, Furgal A, et al. Germline genetic testing after cancer diagnosis. JAMA. 2023;330(1):43-51.

Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study

Kwan ML, Valice E, Ergas IJ, et al. Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study. Cancer. 2023;129(24):3938-3951.

Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia

Li Z, Chang TC, Junco JJ, et al. Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia. Blood. 2023;142(2):172-184.

Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions

Lindström S, Wang L, Feng H, et al. Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions. J Natl Cancer Inst. 2023;115(6):712-732.

The prostate stromal transcriptome in aggressive and lethal prostate cancer

Ma C, Zhou Y, Fanelli GN, et al. The prostate stromal transcriptome in aggressive and lethal prostate cancer. Mol Cancer Res. 2023;21(3):253-260.

Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study

Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia

Associations of Biomarker-Calibrated Healthy Eating Index-2010 scores with chronic disease risk and their dependency on energy intake and body mass index in postmenopausal women

Heritable traits and lung cancer risk: a two-sample Mendelian randomization study

Pettit RW, Byun J, Han Y, et al. Heritable traits and lung cancer risk: a two-sample Mendelian randomization study. Cancer Epidemiol Biomarkers Prev. 2023;32(10):1421-1435.

Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study

Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women

Romanos-Nanclares A, Tabung FK, Sinnott JA, et al. Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women. J Natl Cancer Inst. 2023;115(3):311-321.

Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: a population-based cohort study in Taiwan, 2004 to 2015

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort

Su YR, Sakoda LC, Jeon J, et al. Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort. Cancer Epidemiol Biomarkers Prev. 2023;32(3):353-362.

Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression

Molecular characteristics of early-onset colorectal cancer according to detailed anatomical locations: comparison with later-onset cases

Optimal dietary patterns for prevention of chronic disease

Wang P, Song M, Eliassen AH, et al. Optimal dietary patterns for prevention of chronic disease. Nat Med. 2023;29(3):719-728.

Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non-muscle-invasive bladder cancer: findings from the Be-Well Study

Recapitulation of patient-specific 3D chromatin conformation using machine learning

Xu D, Forbes AN, Cohen S, Palladino A, Karadimitriou T, Khurana E. Recapitulation of patient-specific 3D chromatin conformation using machine learning. Cell Rep Methods. 2023;3(9):100578.

Pancreatic cancer is associated with medication changes prior to clinical diagnosis

Zhang Y, Wang QL, Yuan C, et al. Pancreatic cancer is associated with medication changes prior to clinical diagnosis. Nat Commun. 2023;14(1):2437.

Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data

Associations between genetically predicted levels of blood metabolites and pancreatic cancer risk

Zhong H, Liu S, Zhu J, Wu L. Associations between genetically predicted levels of blood metabolites and pancreatic cancer risk. Int J Cancer. 2023;153(1):103-110.

Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects

Funding Opportunities

  • Stephen I. Katz Early Stage Investigator Research Project Grant
    • PAR-24-075 (R01, Clinical Trial Not Allowed)
    • PAR-24-076 (R01, Basic Experimental Studies with Humans Required)
  • PAR-24-072, Cancer Prevention and Control Clinical Trials Grant Program (R01, Clinical Trial Required)
  • NOT-CA-24-020, Notice of NCI’s Participation in NIH Mentored Research Scientist Development Awards (Parent K01) Notices of Funding Opportunity
  • NOT-CA-24-022, Notice of Special Interest (NOSI): National Cancer Institute Supports Applications for the Mentored Research Scientist Development Awards (K01) Within the Mission of the Division of Cancer Control and Population Sciences
  • NOT-OD-24-031, NOSI: Administrative Supplement for Research and Capacity Building Efforts Related to Bioethical Issues (Admin Supp, Clinical Trial Optional)
  • NOT-CA-24-008, Notice of Intent to Publish a Funding Opportunity Announcement for Cancer Health Disparities and Minority Health (U54, Clinical Trial Optional)

Grants Policy Announcements

  • NOT-OD-24-054, 2024 NIH Grants Policy Updates – Register to Join this Virtual Event on Wednesday, January 31
  • NOT-OD-24-043, Reminder: NIH Natural Disaster and Other Emergencies Flexibilities
  • NOT-OD-24-047, Reminder for NIH Closeout Reporting Requirements and Closeout Email Notifications
  • NOT-OD-24-042, Reminder of eRA Commons ID Requirement for All Personnel on the R&R Senior/Key Person Profile Form

Requests for Information

Job and Training Opportunities

News and Blog Posts

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