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Announcing EGRP's 2023 Research Highlights!
Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. EGRP asked NCI grantees with projects supported by current or recently closed grants (i.e., grants that ended in 2022 or 2023) administered by EGRP to select and submit a research publication resulting from the grant. Submitted articles had to include an acknowledgement of the grant funding and comply with all NIH data sharing policies.
Below are the final selections for EGRP's 2023 Research Highlights, listed in alphabetical order by first author.
A genetic locus within the FMN1/GREM1 gene region interacts with body mass index in colorectal cancer risk
Aglago EK, Kim A, Lin Y, et al. A genetic locus within the FMN1/GREM1 gene region interacts with body mass index in colorectal cancer risk. Cancer Res. 2023;83(15):2572-2583.
Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer
Barrera C, Corredor G, Viswanathan VS, et al. Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer. NPJ Precis Oncol. 2023;7(1):52.
Age-related differences in employment, insurance, and financial hardship among colorectal cancer patients: a report from the ColoCare Study
Berghuijs KMVT, Kaddas HK, Trujillo G, et al. Age-related differences in employment, insurance, and financial hardship among colorectal cancer patients: a report from the ColoCare Study. J Cancer Surviv. Published online March 23, 2023.
Historical redlining and breast cancer treatment and survival among older women in the United States
Bikomeye JC, Zhou Y, McGinley EL, et al. Historical redlining and breast cancer treatment and survival among older women in the United States. J Natl Cancer Inst. 2023;115(6):652-661.
Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study
Chen C, Qin N, Wang M, et al. Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study. Lancet Oncol. 2023;24(10):1147-1156.
Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma
Chen P, Rojas FR, Hu X, et al. Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma. Mod Pathol. Published online September 9, 2023.
Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation
Chen Z, Song W, Shu XO, et al. Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation. J Natl Cancer Inst. Published online August 26, 2023.
Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry
Darst BF, Shen J, Madduri RK, et al. Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry. Am J Hum Genet. 2023;110(7):1200-1206.
Pathological imaging-assisted cancer gene-environment interaction analysis
Fang K, Li J, Zhang Q, Xu Y, Ma S. Pathological imaging-assisted cancer gene-environment interaction analysis. Biometrics. Published online May 17, 2023.
A joint transcriptome-wide association study across multiple tissues identifies candidate breast cancer susceptibility genes
Gao G, Fiorica PN, McClellan J, et al. A joint transcriptome-wide association study across multiple tissues identifies candidate breast cancer susceptibility genes. Am J Hum Genet. 2023;110(6):950-962.
Lipidome of mammographic breast density in premenopausal women
Getz KR, Jeon MS, Luo C, Luo J, Toriola AT. Lipidome of mammographic breast density in premenopausal women. Breast Cancer Res. 2023;25(1):121.
Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death
Gibbs DC, Thomas NE, Kanetsky PA, et al. Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death. JNCI Cancer Spectr. 2023;7(5):pkad051.
A novel human papillomavirus and host DNA methylation score and detection of cervical adenocarcinoma
Gradissimo A, Clarke MA, Xue X, et al. A novel human papillomavirus and host DNA methylation score and detection of cervical adenocarcinoma. J Natl Cancer Inst. 2023;115(12):1535-1543.
Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma
Guerra G, McCoy L, Hansen HM, et al. Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma. Neuro Oncol. 2023;25(6):1047-1057.
Examination of fully automated mammographic density measures using LIBRA and breast cancer risk in a cohort of 21,000 non-Hispanic White women
Habel LA, Alexeeff SE, Achacoso N, et al. Examination of fully automated mammographic density measures using LIBRA and breast cancer risk in a cohort of 21,000 non-Hispanic White women. Breast Cancer Res. 2023;25(1):92.
Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes
Himbert C, Ose J, Gigic B, et al. Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes. BMC Cancer. 2023;23(1):300.
Accelerometer-measured physical activity and postmenopausal breast cancer incidence in the Women's Health Accelerometry Collaboration
Hyde ET, LaCroix AZ, Evenson KR, et al. Accelerometer-measured physical activity and postmenopausal breast cancer incidence in the Women's Health Accelerometry Collaboration. Cancer. 2023;129(10):1579-1590.
Identification of target proteins for breast cancer genetic risk loci and blood risk biomarkers in a large study by integrating genomic and proteomic data
Jia G, Yang Y, Ping J, et al. Identification of target proteins for breast cancer genetic risk loci and blood risk biomarkers in a large study by integrating genomic and proteomic data. Int J Cancer. 2023;152(11):2314-2320.
Longitudinal analysis of change in mammographic density in each breast and its association with breast cancer risk
Jiang S, Bennett DL, Rosner BA, Colditz GA. Longitudinal analysis of change in mammographic density in each breast and its association with breast cancer risk. JAMA Oncol. 2023;9(6):808-814.
Genetically adjusted PSA levels for prostate cancer screening
Kachuri L, Hoffmann TJ, Jiang Y, et al. Genetically adjusted PSA levels for prostate cancer screening. Nat Med. 2023;29(6):1412-1423.
Circulating proteome for pulmonary nodule malignancy
Khodayari Moez E, Warkentin MT, Brhane Y, et al. Circulating proteome for pulmonary nodule malignancy. J Natl Cancer Inst. 2023;115(9):1060-1070.
Potential utility of risk stratification for multicancer screening with liquid biopsy tests
Kim ES, Scharpf RB, Garcia-Closas M, Visvanathan K, Velculescu VE, Chatterjee N. Potential utility of risk stratification for multicancer screening with liquid biopsy tests. NPJ Precis Oncol. 2023;7(1):39.
Germline genetic testing after cancer diagnosis
Kurian AW, Abrahamse P, Furgal A, et al. Germline genetic testing after cancer diagnosis. JAMA. 2023;330(1):43-51.
Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study
Kwan ML, Valice E, Ergas IJ, et al. Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study. Cancer. 2023;129(24):3938-3951.
Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia
Li Z, Chang TC, Junco JJ, et al. Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia. Blood. 2023;142(2):172-184.
Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions
Lindström S, Wang L, Feng H, et al. Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions. J Natl Cancer Inst. 2023;115(6):712-732.
The prostate stromal transcriptome in aggressive and lethal prostate cancer
Ma C, Zhou Y, Fanelli GN, et al. The prostate stromal transcriptome in aggressive and lethal prostate cancer. Mol Cancer Res. 2023;21(3):253-260.
Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study
Mandelblatt JS, Ruterbusch JJ, Thompson HS, et al. Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study. Cancer. 2023;129(10):1557-1568.
Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia
Mariapun S, Ho WK, Eriksson M, et al. Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia. Breast Cancer Res Treat. 2023;201(2):237-245.
Associations of Biomarker-Calibrated Healthy Eating Index-2010 scores with chronic disease risk and their dependency on energy intake and body mass index in postmenopausal women
Neuhouser ML, Pettinger M, Tinker LF, et al. Associations of Biomarker-Calibrated Healthy Eating Index-2010 scores with chronic disease risk and their dependency on energy intake and body mass index in postmenopausal women. J Nutr. 2023;152(12):2808-2817.
Heritable traits and lung cancer risk: a two-sample Mendelian randomization study
Pettit RW, Byun J, Han Y, et al. Heritable traits and lung cancer risk: a two-sample Mendelian randomization study. Cancer Epidemiol Biomarkers Prev. 2023;32(10):1421-1435.
Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study
Richardson DB, Leuraud K, Laurier D, et al. Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study. BMJ. 2023;382:e074520.
Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women
Romanos-Nanclares A, Tabung FK, Sinnott JA, et al. Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women. J Natl Cancer Inst. 2023;115(3):311-321.
Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: a population-based cohort study in Taiwan, 2004 to 2015
Sirirungreung A, Lee PC, Hu YH, Liew Z, Ritz B, Heck JE. Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: a population-based cohort study in Taiwan, 2004 to 2015. Int J Cancer. Published online October 4, 2023.
MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer
Song X, Ji J, Rothstein JH, et al. MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer. Nat Commun. 2023;14(1):377.
Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort
Su YR, Sakoda LC, Jeon J, et al. Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort. Cancer Epidemiol Biomarkers Prev. 2023;32(3):353-362.
Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression
Tian Y, Dong D, Wang Z, et al. Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression. Am J Hum Genet. 2023;110(8):1289-1303.
Molecular characteristics of early-onset colorectal cancer according to detailed anatomical locations: comparison with later-onset cases
Ugai T, Haruki K, Harrison TA, et al. Molecular characteristics of early-onset colorectal cancer according to detailed anatomical locations: comparison with later-onset cases. Am J Gastroenterol. 2023;118(4):712-726.
Optimal dietary patterns for prevention of chronic disease
Wang P, Song M, Eliassen AH, et al. Optimal dietary patterns for prevention of chronic disease. Nat Med. 2023;29(3):719-728.
Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non-muscle-invasive bladder cancer: findings from the Be-Well Study
Wang Z, Kwan ML, Haque R, et al. Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non-muscle-invasive bladder cancer: findings from the Be-Well Study. Am J Clin Nutr. 2023;117(6):1110-1120.
Recapitulation of patient-specific 3D chromatin conformation using machine learning
Xu D, Forbes AN, Cohen S, Palladino A, Karadimitriou T, Khurana E. Recapitulation of patient-specific 3D chromatin conformation using machine learning. Cell Rep Methods. 2023;3(9):100578.
Pancreatic cancer is associated with medication changes prior to clinical diagnosis
Zhang Y, Wang QL, Yuan C, et al. Pancreatic cancer is associated with medication changes prior to clinical diagnosis. Nat Commun. 2023;14(1):2437.
Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data
Zhao M, Lau MC, Haruki K, et al. Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data. NPJ Precis Oncol. 2023;7(1):57.
Associations between genetically predicted levels of blood metabolites and pancreatic cancer risk
Zhong H, Liu S, Zhu J, Wu L. Associations between genetically predicted levels of blood metabolites and pancreatic cancer risk. Int J Cancer. 2023;153(1):103-110.
Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects
Zhong H, Zhu J, Liu S, et al. Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects. Hum Mol Genet. 2023;32(22):3181-3193.