Danielle Daee, Ph.D.
Program Director, Genomic Epidemiology Branch

Address:
Epidemiology and Genomics Research Program
Division of Cancer Control and Population Sciences
National Cancer Institute
National Institutes of Health
9609 Medical Center Drive, Rm. 4E236, MSC 9763
Bethesda, MD 20892
(For express delivery, use Rockville, MD 20850)

Interest Areas

  • Genetic susceptibility to cancer

Degrees

  • Ph.D. - Pathology and Microbiology with training in Cancer Research
    University of Nebraska
  • B.S. - Biology, Minor Chemistry
    Truman State University

Biography

Dr. Danielle Daee is a Program Director in the Genomic Epidemiology Branch (GEB) of the Epidemiology and Genomics Research Program (EGRP) in NCI's Division of Cancer Control and Population Sciences (DCCPS). In this position, Dr. Daee will lead the assessment and evaluation of several ongoing EGRP initiatives. Her responsibilities will also include managing a portfolio of grants related to genetic factors modulating susceptibility to cancer in general and in pediatric cancers specifically. Notably, Dr. Daee will represent EGRP on the Gabriella Miller Kids First Pediatric Research ProgramExternal Web Site Policy.

Prior to joining EGRP, Dr. Daee was a Health Science Analyst in NCI's Office of Science Planning and Assessment (OSPA). In this position, she supported the mission of NCI by helping Divisions, Offices, and Centers evaluate the impact of their scientific research investments by performing and consulting on program assessments and portfolio analyses. Dr. Daee also worked to disseminate health information by developing scientific content for the web, including the Cancer Snapshots, and coordinating responses across NCI for program assessment related questions.

Dr. Daee was a postdoctoral fellow at the National Human Genome Research Institute (NHGRI) at NIH before joining NCI. During her fellowship, she identified and studied yeast homologs in the Fanconi Anemia DNA repair pathway. Through her research career, Dr. Daee developed an expertise in DNA repair, DNA replication, and yeast genetics.

Publications

Kochenova OV, Daee DL, Mertz TM, Shcherbakova PV. DNA Polymerase zeta-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNAExternal Web Site Policy. PLoS Genetics. 2015 Mar;11(3):e1005110.

Daee DL, Myung K. Fanconi-like crosslink repair in yeastExternal Web Site Policy. Genome Integrity. 2012 Oct;3(1):7.

Daee DL, Ferrari E, Longerich S, Zeng XF, Xue X, Branzei D, Sung P, Myung K. RAD5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM homolog Mph1External Web Site Policy. J Biol Chem. 2012 Aug;287(32):26563-75.

Daee DL, Myung K. Small RFC subunits make a big differenceExternal Web Site Policy. Cell Cycle. 2010 Nov;9(22):4429.

Yan Z, Delannoy M, Ling C, Daee D, et al. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stabilityExternal Web Site Policy. Mol Cell. 2010 Mar;37(6):865-878.

Daee DL, Mertz TM, Shcherbakova PS. A cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instabilityExternal Web Site Policy. Proc Natl Acad Sci. 2010 Jan;107(1):157-162.

Erlich RL, Fry RC, Begley TJ, Daee DL, Lahue RS, Samson LD. Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiaeExternal Web Site Policy. PLoS ONE. 2008;3(11):e3717.

Daee DL, Mertz T, Lahue RS. Postreplication repair inhibits CAG·CTG expansions in Saccharomyces cerevisiaeExternal Web Site Policy. Mol Cell Biol. 2007 Jan;27(1):102-110.

Lahue RS, Slater DL. DNA repair and trinucleotide repeat instabilityExternal Web Site Policy. Front Biosci. Review Article. 2003 May;8:s653-65.

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